Protein Alignment Ae2 and slc4a10

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_031749361.1
• Gene: slc4a10 / 100488456
• XenbaseID: XB-GENE-1011116
• Length: 1104
• Species: Xenopus tropicalis
• Alignment Length: 1213
• Identity: 390/1213 - (32%)
• Similarity: 599/1213 - (49%)
• Gaps: 230/1213 - (18%)

  Fly    85 EDSEYESQTEPLNNAQNYDDIPEDFPLVSERAG-------HGDHSDNSVDEK-----HVQFGGKK 137
            |..:..:|.|||...:|      |...|.:|.|       |.:..|......     ||..||:|
 Frog     2 EIKDQGAQMEPLLPTRN------DEEAVVDRGGTRSLLKTHFEKEDLEGHRTLFIGVHVPLGGRK 60

  Fly   138 KIPPSLSYDEQPTDQSHERKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRISVQPEDTA 202
                           ||    ||.||:.::.||...:                        .|:.
 Frog    61 ---------------SH----RRHRHRGHKHRKRDRE------------------------RDSG 82

  Fly   203 LEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITISPFTNKKPEVDHSPHEIFVQLDEL- 266
            ||:.     |...:.|..:.|...|                 ...:..:.:|.||::|.:|||:
 Frog    83 LEDG-----RESPTYDTPSQRVQFI-----------------LGTEDDDEEHIPHDLFTELDEIC 125

  Fly   267 TGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPA 331
            ...|:|.||:|.|||:|:|||||:|.:||.||:||:||.|||..||.|:..|.||||:....|..
 Frog   126 LREGDDAEWREMARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILHGTVLLDMRANTLEE 190

  Fly   332 VAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQ--GVLPFTKRKYNSYTSLQFLWMGADS 394
            :|..:::|.|....:..:.:..|..:||.:|.|.|:.:  ..:|..:         .|..:|
 Frog   191 IADMILDQQVASGQLSEDVRHRVHEALLKQHHHQNQKKLSNRIPIVR---------SFADIG--- 243

  Fly   395 AHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTD 459
                  :.|..|.::.|..:.:. ..|||               :.|:|:...
 Frog   244 ------KKQSEPHSMDKTGQLVS-PQSAP---------------SCIEHKNDV------------ 274

  Fly   460 DKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEF 524
                          |:.::.|.: .|.|::              .:|:||.||||:.:|||.:||
 Frog   275 --------------SRENSTLDV-TKFDLH--------------FMKKIPPGAEASNILVGELEF 310

  Fly   525 LEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYK 589
            |::..:||||||..||:..|||||:|.||:|:||||......|||:||||:|||.:|.||.:|||
 Frog   311 LDRAIVAFVRLSPAVLLSGLTEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYK 375

  Fly   590 ADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGK 654
            |.||.||::.|:||||...|||||.||     |...::..|:.....|.|...|...:  ..:|:
 Frog   376 AKDRNDLVAGIDEFLDQVTVLPPGEWD-----PTIRIEPPKNVPSQEKRKTPGVPNGT--AALGE 433

  Fly   655 DEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMY 719
            .||.                ||..|.:                ||:||||:|||..|:||:.|.:
 Frog   434 PEEH----------------GGHSGPE----------------LERTGRLFGGLVLDVKRKAPFF 466

  Fly   720 KSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQP 784
            .||..|..:.:.||:.:|:|.||:|..||||||:...|...|...|:|...|:.||.|.....||
 Frog   467 WSDFKDAFSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAFSLFGGQP 531

  Fly   785 LVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEI 849
            |.|:|:|||:|:|::.|..||..::..:||||..:|:|.....:.:.|.:.|..|..:||||:|.
 Frog   532 LTILGSTGPVLVFEKILFKFCKDYDLSYLSLRASIGLWTAFNCIFLVATDASSLVCYITRFTEEA 596

  Fly   850 FSALITLIYIVETFMKLISIYRENPLLSDYNLPPPT-----LVAHEHATNESLL-----NATASV 904
            |:|||.:|:|.|...||..:....|:..:.||...|     .:..|:.:|::|.     |.|||.
 Frog   597 FAALICIIFIYEALEKLFHLGETYPINMNNNLELLTQYSCGCMEPENPSNKTLTYWQSSNITASE 661

  Fly   905 TT--NITQMVMN------ISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFL 961
            .:  |:|....:      :.......||     ..|:...:..||..||.:::..||.|:.|.:.
 Frog   662 ISWNNLTVDACHKFHGDFVGRACGHEGP-----YVPDVLFWSVILFFATVIMSSTLKQFKTSRYF 721

  Fly   962 GRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIPF 1025
            ....|..:.||.|.::|...||||:.: .:.:.||.||....|: ...|||.:. ...:..|...
 Frog   722 PTKVRSHVSDFAVFLTILTMVLVDFCI-GIPSPKLQVPNEFKPT-RDDRGWIVNPLGRNPWWTVV 784

  Fly  1026 ACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVR 1090
            |.:||:||..|||||:.||:.:|:::.:..||||.|.|.|::::.::...|.:.|:||..||||.
 Frog   785 AAIIPSLLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVGIMLGVCSVMGLPWFVAATVL 849

  Fly  1091 SVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYM 1155
            |:|||:|:.:.|...||||.|:.:.::|||::|..:.:::|.||.|..:|:.|||.||:||||||
 Frog   850 SITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGSSVFMTRILQFIPMPVLYGVFLYM 914

  Fly  1156 GVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFP 1220
            |.:|:.|:|.|:||.||:||.||.|...|::.:...|:||||.||:.||:|||.:|:|:.::.||
 Frog   915 GSSSLKGIQFFDRILLYWMPAKHQPDFIYLRHVPLRKVHLFTIIQLSCLILLWVIKASRAAIVFP 979

  Fly  1221 FFLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDDDEPD 1259
            ..::.:|.:|:.:...:...|:..||.    |:.||.:|.:.:
 Frog   980 MMVLALVFVRKLMDFFFTKRELSWLDDLMPESKKKKLEDAQKE 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	355/1026 (35%)
		Band_3_cyto	287..618	CDD:284893	115/332 (35%)
		HCO3_cotransp	698..1199	CDD:279322	194/519 (37%)
slc4a10	XP_031749361.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040