Protein Alignment Ae2 and slc4a8

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_002933752.2
• Gene: slc4a8 / 100487245
• XenbaseID: XB-GENE-6050275
• Length: 1096
• Species: Xenopus tropicalis
• Alignment Length: 1145
• Identity: 382/1145 - (33%)
• Similarity: 571/1145 - (49%)
• Gaps: 201/1145 - (17%)

  Fly   172 SHQDSVEPKNKLEENGDAGARRISVQPEDTALEEADLNELRSHRS--------DDPRALRRHKIH 228
            |:|.|.| :..:::.|.:....|..:.|          ||..||:        ...::.|.|:.|
 Frog    13 SYQRSDE-EAIVDQGGTSSVLNIHYEKE----------ELEGHRTLYVGVRMPLGRQSHRHHRTH 66

  Fly   229 ------------------HSSIKLRELPQITISPFTNKKPEVDHSPHEIFVQLDEL-TGVGEDRE 274
                              |......:.|...:......:.:.:|.|||:|.:|||: ...|||.|
 Frog    67 GQKHRKRDRMKGVIQEEGHDESSAHDTPSQRVQFILGTEDDEEHVPHELFTELDEICVKEGEDAE 131

  Fly   275 WKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQ 339
            |||||||:|:|||||:|.:||.||:||:||.|||..||.|:..|.|.||:....:..||..:::.
 Frog   132 WKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCIINGTVQLDMRANTIEEVADMILDH 196

  Fly   340 MVIEDLIDINDKPSVMRSLLLRHRHVNE--HQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQA 402
            ....:.:..|.:..|..:||.:|.|..|  ...::|..:         .|..:|         :.
 Frog   197 QDSANELGDNIRVKVKEALLKKHHHQIEKKRNNLIPMVR---------SFAEVG---------KK 243

  Fly   403 QPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMP 467
            |..|..|.|...|:    |..||.:.|:|..
 Frog   244 QSEPHLLDKNSLSV----SPQPTPSTLDVKN---------------------------------- 270

  Fly   468 AAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAF 532
                |||..             :||..||.|:... .:|:||.||||:.||||.::|||:|.:||
 Frog   271 ----GGSHE-------------NSSSVDLSKVDLH-FMKKIPTGAEASNVLVGELDFLERPIVAF 317

  Fly   533 VRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLL 597
            ||||..||:..|||||:|.||:|:||||......|||:|||::|:|.:|.||.:||||.||.|||
 Frog   318 VRLSPAVLLTGLTEVPIPTRFLFILLGPVGKAQQYHEIGRSMATIMTDEIFHDVAYKAKDRGDLL 382

  Fly   598 SAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLE 662
            :.|:||||...|||||.||                               ..|:|...:.....|
 Frog   383 AGIDEFLDQVTVLPPGEWD-------------------------------PSIRIEPPKNVPSQE 416

  Fly   663 KQTLGAIGFTIGGGDGGGDGDSDDDNG---RKKKKPSP------LEKTGRLWGGLRNDLKRRMPM 718
            |:.:..:                 .||   ..:.:|.|      |::||.::|||..|:||:.|.
 Frog   417 KRKMPGV-----------------PNGNVCHVEPEPEPEHSGPELQRTGMIFGGLVADIKRKAPF 464

  Fly   719 YKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQ 783
            |.||..|.|:.:.:|:.:|:|.||:|..||||||:...|...|...|:|...|:.||.:...:.|
 Frog   465 YLSDYRDALSLQCVASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQ 529

  Fly   784 PLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQE 848
            ||.|:|:|||:|:|::.|..||.::...:||||..:|:|...:.:.:.|.:.|..|..:||||:|
 Frog   530 PLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRACIGLWTAFLCIFLVATDASSLVCYITRFTEE 594

  Fly   849 IFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTL-----VAHEHATNESLL-------NAT 901
            .|::||.:|:|.|...|||.:....|:.....|...||     .|....||::||       ..|
 Frog   595 AFASLICIIFIYEAIEKLIHLGETYPVNMHSQLDKLTLYYCKCAAPASPTNDTLLYWRENNITIT 659

  Fly   902 ASVTTNITQMVMN------ISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHF 960
            .:...|.|....|      :.......||     ..|:...:..||...||.::..||.|:.|.:
 Frog   660 EAEWANFTVSECNKMHGEFVGPACGHHGP-----YTPDVLFWSCILFFTTFALSSVLKTFKTSRY 719

  Fly   961 LGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIP 1024
            .....|..:.||.|.::|...|::||:: .|.:.||.||....|: ...|||.:. ...:..|..
 Frog   720 FPTKVRSMVSDFAVFLTILTMVVLDYVI-GVPSPKLQVPNEFKPT-RDDRGWLVNPIGPNPWWTV 782

  Fly  1025 FACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATV 1089
            |..:|||||..|||||:.||:.:|:::.:..||||.|.|.|::::.|:...|.|.|:||..||||
 Frog   783 FPTIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLVVGLMLGICSIMGLPWFVAATV 847

  Fly  1090 RSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLY 1154
            .|:|||:|:.:.|...||||.|:.:.::|||::|..:.:::|.||.|..:|:.|||.||:|||||
 Frog   848 LSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTTVLKFIPMPVLYGVFLY 912

  Fly  1155 MGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAF 1219
            |||:|:.|:|.|:|:.|:.||.||.|..||::.:...|:||||.||:.||||||.:|:|..::.|
 Frog   913 MGVSSLRGIQFFDRLLLFAMPAKHQPDFSYLRHVPLRKVHLFTIIQLTCLVLLWVIKASPAAIVF 977

  Fly  1220 PFFLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDD 1255
            |..::.:|.:|:.:...:...|:..||.    |:.||.||
 Frog   978 PMMVLALVFVRKVMDFCFSDRELSWLDDLMPESKKKKLDD 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	362/1031 (35%)
		Band_3_cyto	287..618	CDD:284893	120/332 (36%)
		HCO3_cotransp	698..1199	CDD:279322	194/519 (37%)
slc4a8	XP_002933752.2	Band_3_cyto	116..1044	CDD:391624	362/1031 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.040