Protein Alignment Ae2 and slc4a3

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_009303236.1
• Gene: slc4a3 / 100333073
• ZFINID: ZDB-GENE-141006-1
• Length: 1229
• Species: Danio rerio
• Alignment Length: 1257
• Identity: 508/1257 - (40%)
• Similarity: 718/1257 - (57%)
• Gaps: 199/1257 - (15%)

  Fly    71 RKKNSIRTNDL--------NIEEDSEYESQ------TEPLN-----NAQNYDDIPEDFPL----- 111
            :||.|:..:|:        ..|.:||.|.|      |||..     :..:.:|:..|.||
Zfish   109 KKKTSMPPSDVTPTIHEVDEEEAESEIEGQCQAATPTEPSEELPQLSLGSEEDLAADLPLSSFHM 173

  Fly   112 VSERAGHGDH---SDNSVDEKHVQFGGKKKIPP--------SLSYDEQPTDQSHERK---RRRSR 162
            .|||....:.   |..|::||.     :.:.||        |.|:...|...|...:   ||:..
Zfish   174 ESERPASSEETLPSPASMEEKE-----ETQQPPDGGEHKDISNSFSPSPEAASMTTRGWFRRKPV 233

  Fly   163 HQYYRQRKFSHQDSVEPKNKLEEN---GDAGARRISVQ---PEDTA----LEEADLNELRSHRSD 217
            |:....::.|:.        |.|.   |...|...:|.   |.|.|    |..|||::::|||.:
Zfish   234 HRLAGAQRTSYD--------LRERICIGSMTAMETAVYQKVPTDEAEAQMLASADLDDMKSHRFE 290

  Fly   218 DPRALRRHKIHHSSIKLRELPQIT-----ISPFTNKKPEVDHSPHEIFVQLDEL-TGVGEDREWK 276
            |...:|||.:..||  ..:||:.:     :|....:| .:|...||:||:|:|| ....::..||
Zfish   291 DNPGVRRHLVKKSS--RCQLPRSSNGSPPLSSLKRRK-RMDKKTHEVFVELNELIVDKNQEMRWK 352

  Fly   277 ETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMV 341
            |.|||||:||||||.:|||||||||||||.|||.|||.:..|.::|||::..||.:|:.:||.|:
Zfish   353 ERARWIKFEEDVEEETDRWGKPHVASLSFRSLLELRRTITHGAIMLDLDQTTLPGIAHLMVETMI 417

  Fly   342 IEDLIDINDKPSVMRSLLLRHRHVN-EHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPP 405
            |.|.|...|:.:|:|:|||:|.|.| |.:|:.    .:.:|.|||.......:..|
Zfish   418 ISDQIRAEDRANVLRALLLKHSHPNDEKEGLF----HRNHSVTSLGSFRHNHNHVH--------- 469

  Fly   406 PRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAE 470
                          .::.|..:..:.....:.||  ||.:              :|.:..:||.
Zfish   470 --------------DTSLPLVSQDHEEMHDSKAA--DHDK--------------EKSLHPIPAE- 503

  Fly   471 IGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRL 535
              |...|..||                      :|.:||..||||.||||.|||||:|.:|||||
Zfish   504 --GHAASRSLK----------------------LLAKIPKDAEATVVLVGCVEFLEKPAMAFVRL 544

  Fly   536 SEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAI 600
            :|.:|:.::.|||||:||:||||||...::||||:|||.||||::::||.:||.||||:|||:.|
Zfish   545 NESILLESILEVPVPIRFIFVLLGPTQTNVDYHEIGRSFSTLMSDKNFHEVAYFADDRQDLLNGI 609

  Fly   601 NEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQT 665
            |||||.|||:||.:.:..|||. .....:|..:|.||        :.|:.|.......|.||.:
Zfish   610 NEFLDCSIVIPPSDVEGKDLLK-TVASFQKQMLRKRK--------ERELKKCASTVTGAELETK- 664

  Fly   666 LGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTE 730
                           |.:.::.....:....||:::|..:|||.:|::||.|.|.||:.|.|:|:
Zfish   665 ---------------DVNIEEQEEEDQFDVDPLKRSGIPFGGLIHDIRRRYPRYISDLKDALDTQ 714

  Fly   731 TLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLL 795
            .:||.||:|||.||..||||||:..||...:|:||.:||.:.||::|..|:.|||:|||.:||||
Zfish   715 CIAAVIFIYFAALSPTITFGGLLGEKTQGMMGVSELIISTATVGVLFSLLAGQPLLIIGFSGPLL 779

  Fly   796 LFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIV 860
            :|:||...||....|::|:.||::|.|||.|.|.:.|.|||..||.::.||||||:.||:||:|.
Zfish   780 VFEEAFYKFCQAQGFEYLTGRVWIGFWLIFIVLVIVAAEGSFLVRYISPFTQEIFAFLISLIFIY 844

  Fly   861 ETFMKLISIYRENPLLSDYNLPPPTLVAHEHATNESLLNATASVTTNITQMVMNISTTAMPIGPP 925
            |||.|||.:::|:||:..|     |..|.:|:....     :||                 ||.|
Zfish   845 ETFSKLIKVFQEHPLMMSY-----TSAAFKHSDQRG-----SSV-----------------IGEP 882

  Fly   926 PLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPA 990
            .|  |||||||...:|.:.||..|::|:..|||.|||...||.:||||:||||.|.||||.|:|.
Zfish   883 IL--NQPNTALLSMVLMMGTFFTAFFLRKLRNSRFLGGKVRRVIGDFGIPISILISVLVDILIPD 945

  Fly   991 VYTEKLVVPEGLSPSDPSKRGWYIG-FDTSS---TWIPFACVIPALLVYILIFMESQISELIVDK 1051
            .||:||.||.|.|.:.|.||||:|. |....   .|:..|.|||||||:||||||:||:.|||.|
Zfish   946 TYTQKLNVPSGFSVTSPDKRGWFISPFGDKQPFPVWMMGASVIPALLVFILIFMETQITTLIVSK 1010

  Fly  1052 PDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDV 1116
            .:|.|.||||.|.|::|:..|...|.:||:||..||||||||||:::|:||:..||||.|.|.:|
Zfish  1011 KERRLMKGSGFHLDLLLIVTLGAICPLFGLPWLTAATVRSVTHVNALTVMSKATAPGEKPMIQEV 1075

  Fly  1117 KEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPP 1181
            ||||::|..|.:::|||::|..:||.||:|||||:|||||:.|::|:||:|||.|...|.||:|.
Zfish  1076 KEQRVTGMCVAILVGLSIVMTDVLRHIPLAVLFGIFLYMGITSLTGIQLYERITLMVTPAKHHPD 1140

  Fly  1182 TSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQ-NLTKLYKPEEMQAL 1245
            ..||.:::.|::::||.||:||:||||.|||:..||||||.|||.||:|: .||::::..|:.||
Zfish  1141 HVYVTKVKTWRMNMFTVIQLLCIVLLWVVKSTVASLAFPFILIMTVPLRRLILTRIFEERELAAL 1205

  Fly  1246 DGSEMKKN-DDDEPDFYEQTNI 1266
            |..|...| |:|..|.|.:.::
Zfish  1206 DADEDSPNFDEDGRDEYNEIHM 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	447/1015 (44%)
		Band_3_cyto	287..618	CDD:284893	134/331 (40%)
		HCO3_cotransp	698..1199	CDD:279322	249/504 (49%)
slc4a3	XP_009303236.1	ae	335..1227	CDD:273290	447/1013 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575033
Domainoid	1	1.000	255	1.000	Domainoid score	I2005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	820	1.000	Inparanoid score	I455
OMA	1	1.010	-	-		QHG48894
OrthoDB	1	1.010	-	-		D173913at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm24637
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	1	1.100	-	-	O	PTHR11453
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910