DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and TRIL

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_055632.2	Gene:	TRIL / 9865	HGNCID:	22200	Length:	811	Species:	Homo sapiens

Alignment Length:	336	Identity:	114/336 - (33%)
Similarity:	165/336 - (49%)	Gaps:	36/336 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 NFSHNALKQCDLPHMPLLNRLELGHNRLVN---ATFGVCPQLQELILNDNQLIQLDVNAFRGLHG 219
            ||..| :...|...:..|.||:|.:|::.:   .||....:|:||.|.:|.|..|.......|..
Human    69 NFITN-ITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRK 132

  Fly   220 LLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFV-LHLQQLDLSGNRIR 283
            |..|..:||.:|.:...:|:.|..|.||.|..|||.||...||..:.|.: |||:     .||||
Human   133 LRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLE-----SNRIR 192

  Fly   284 LLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLD 348
            .|..|.|..|.:|:.|::|.|   .|.|       |||            ..||||.|.:|.:|.
Human   193 FLGKNAFAQLGKLRFLNLSAN---ELQP-------SLR------------HAATFAPLRSLSSLI 235

  Fly   349 LSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFA 413
            ||.|||:.|..:||  ..|||:..|:|.||::.||.|.||..|..|..|:|..|.|..|...:..
Human   236 LSANNLQHLGPRIF--QHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLE 298

  Fly   414 PMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLA-KVNVSFPNLKRVAIEGNPWQC 477
            |:..|:.|.|..|.|..::......|..::|:.:.||.|:.|: .:..:.|.|.|:.::||.|.|
Human   299 PLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTC 363

  Fly   478 PCFVK-LQHWL 487
            .|.:: |:.|:
Human   364 DCRLRGLKRWM 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	33/100 (33%)
		LRR_8	104..164	CDD:290566	3/5 (60%)
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	11/39 (28%)
		LRR_RI	194..455	CDD:238064	92/261 (35%)
		LRR_8	194..254	CDD:290566	20/59 (34%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	11/22 (50%)
		LRR_8	271..330	CDD:290566	19/58 (33%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	25/60 (42%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	11/24 (46%)
		LRR_8	368..428	CDD:290566	23/59 (39%)
		leucine-rich repeat	370..393	CDD:275380	10/22 (45%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	6/22 (27%)
TRIL	NP_055632.2	LRR_RI	<2..194	CDD:238064	45/130 (35%)
		leucine-rich repeat	37..61	CDD:275380
		LRR 1	61..81		4/12 (33%)
		leucine-rich repeat	62..84	CDD:275380	4/15 (27%)
		LRR_8	84..143	CDD:290566	19/58 (33%)
		LRR 2	84..105		7/20 (35%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR 3	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR 4	132..153		6/20 (30%)
		leucine-rich repeat	133..156	CDD:275380	7/22 (32%)
		LRR_8	156..215	CDD:290566	27/66 (41%)
		LRR 5	156..177		11/20 (55%)
		leucine-rich repeat	157..180	CDD:275380	11/22 (50%)
		LRR 6	180..201		11/25 (44%)
		leucine-rich repeat	181..204	CDD:275380	11/27 (41%)
		LRR 7	204..223		9/40 (23%)
		leucine-rich repeat	205..254	CDD:275380	25/72 (35%)
		LRR 8	230..251		10/22 (45%)
		LRR_8	239..289	CDD:290566	23/51 (45%)
		LRR_RI	<249..>364	CDD:238064	38/116 (33%)
		LRR 9	254..275		10/20 (50%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		LRR 10	278..299		6/20 (30%)
		LRR_8	279..337	CDD:290566	16/57 (28%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR 11	302..323		5/20 (25%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		LRR 12	326..347		5/20 (25%)
		leucine-rich repeat	327..346	CDD:275380	5/18 (28%)
		leucine-rich repeat	351..363	CDD:275378	5/11 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..549
		fn3	589..667	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11342
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940