DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and CYR1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	585	Identity:	145/585 - (24%)
Similarity:	222/585 - (37%)	Gaps:	151/585 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LDLTGAAPINVHTN-------GFSILPNLRQLNLSGCGLVDIRGNHFA--PE-----SALQRIDF 135
            :.|:....:|:..|       ||..|.||:        |:|:..|.|.  ||     :.|.:||.
Yeast   883 MKLSNLTILNLQCNELESLPAGFVELKNLQ--------LLDLSSNKFMHYPEVINYCTNLLQIDL 939

  Fly   136 SHNQMELLDRDFFGNLRKLIYANFSHNALKQC-DLPHMPLLNRLELGHNRL----VNATFGVCPQ 195
            |:|:::.|.:. ...|.||...|.|||.|... ||..|..|..|.|.:||:    .||:     .
Yeast   940 SYNKIQSLPQS-TKYLVKLAKMNLSHNKLNFIGDLSEMTDLRTLNLRYNRISSIKTNAS-----N 998

  Fly   196 LQELILNDNQL------------IQLDVN-----AFRGLH--GLLELQLSGNRLSSIGLETFQPL 241
            ||.|.|.||::            :::..|     :|:..:  .:..|.|:..:||||..|....|
Yeast   999 LQNLFLTDNRISNFEDTLPKLRALEIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELLTKL 1063

  Fly   242 AQLRKLNLSQNALDALRPNVFGAVQNFVL-------------------HLQQLDLSGNRIRLLFD 287
            :.|.||.|:||.|..| |.....:...|.                   .|:.|||..|.||...|
Yeast  1064 SFLEKLELNQNNLTRL-PQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVD 1127

  Fly   288 NQFRVLARLQMLDVSRNSIASLSPA----HFVGLGSLRKLYLQY-----NAILEIKPATFAALLN 343
            ....:  .|..|::|.|:..:.|..    |.:..||.....|.:     |...:.....|...:|
Yeast  1128 GMENL--ELTSLNISSNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVN 1190

  Fly   344 LDTLDLSYNN--------LEFLEEQIFGGNTL-----------PRMRRLNLNGNRMKHLHPLAFS 389
            |..|:|||||        ||.:.|....||.|           ..::.|.||.|:|..| |...|
Yeast  1191 LKVLNLSYNNFSDVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSL-PAELS 1254

  Fly   390 SLPFLEYLKLGHNEL----------------KSLDVRMFAPMRRLQ-KLHLGHNLLEEI-NLDVL 436
            :|..|....:|.|:|                |.|....|:..||.: |..:.|::..:: :|.||
Yeast  1255 NLSQLSVFDVGANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVL 1319

  Fly   437 ESLS-------SVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVY 494
            ..|.       ::....|.:..:.|..:...|..|..|..:.....|       :.::::|||.:
Yeast  1320 PQLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQ-------RDYVSSRDVTF 1377

  Fly   495 LRDNTGYYKGERPLCIV-------TNVDYCIQNLQAVRRLGILGDFQGEQVE--ADAFDDDASAA 550
            .|     ::|....|::       .|.||. .|:..:.| .|.......|:|  .|..||:...|
Yeast  1378 ER-----FRGNDDECLLCLHDSKNQNADYG-HNISRIVR-DIYDKILIRQLERYGDETDDNIKTA 1435

Fly 551 550
Yeast 1436 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	56/183 (31%)
		LRR_8	104..164	CDD:290566	21/66 (32%)
		leucine-rich repeat	106..129	CDD:275380	7/29 (24%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	16/45 (36%)
		LRR_RI	194..455	CDD:238064	84/351 (24%)
		LRR_8	194..254	CDD:290566	22/78 (28%)
		leucine-rich repeat	196..219	CDD:275380	8/41 (20%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	18/67 (27%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	6/26 (23%)
		LRR_8	319..380	CDD:290566	22/84 (26%)
		leucine-rich repeat	320..343	CDD:275380	3/27 (11%)
		leucine-rich repeat	344..369	CDD:275380	13/43 (30%)
		LRR_8	368..428	CDD:290566	20/76 (26%)
		leucine-rich repeat	370..393	CDD:275380	9/22 (41%)
		leucine-rich repeat	394..417	CDD:275380	7/38 (18%)
		leucine-rich repeat	418..441	CDD:275380	6/31 (19%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	110/407 (27%)
		leucine-rich repeat	796..817	CDD:275380
		leucine-rich repeat	818..839	CDD:275380
		leucine-rich repeat	840..864	CDD:275380
		leucine-rich repeat	865..887	CDD:275380	1/3 (33%)
		leucine-rich repeat	888..910	CDD:275380	5/21 (24%)
		leucine-rich repeat	911..933	CDD:275380	7/29 (24%)
		leucine-rich repeat	934..956	CDD:275380	7/22 (32%)
		leucine-rich repeat	957..978	CDD:275380	9/20 (45%)
		leucine-rich repeat	979..1018	CDD:275380	13/43 (30%)
		leucine-rich repeat	1019..1041	CDD:275380	2/21 (10%)
		leucine-rich repeat	1042..1065	CDD:275380	8/22 (36%)
		leucine-rich repeat	1066..1088	CDD:275380	9/22 (41%)
		leucine-rich repeat	1089..1111	CDD:275380	1/21 (5%)
		leucine-rich repeat	1167..1187	CDD:275380	3/19 (16%)
		leucine-rich repeat	1191..1211	CDD:275380	8/19 (42%)
		leucine-rich repeat	1236..1258	CDD:275380	9/22 (41%)
		leucine-rich repeat	1259..1287	CDD:275380	4/27 (15%)
		PP2C	1374..1617	CDD:395385	17/69 (25%)
		CYCc	1613..1825	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870