DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Igfals

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_445781.3	Gene:	Igfals / 79438	RGDID:	68429	Length:	603	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	150/496 - (30%)
Similarity:	224/496 - (45%)	Gaps:	75/496 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NFQCSEVASLQDLVDLGAEN-WHTLAIRNVQTELEVGSGENADHLANL-LDLDLTGAAPINVHTN 98
            |.|.|.:.||:....||.:| :|....||....|.||...:...||:| |..:|.|    .:...
  Rat   104 NLQGSWLRSLEPQALLGLQNLYHLHLERNRLRNLAVGLFTHTPSLASLSLSSNLLG----RLEEG 164

  Fly    99 GFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNA 163
            .|..|.:|..|||....||.:      |::..|.:               |||.:|:.|......
  Rat   165 LFQGLSHLWDLNLGWNSLVVL------PDTVFQGL---------------GNLHELVLAGNKLTY 208

  Fly   164 LKQCDLPHMPLLNRLELGHNRLVNATFGV---CPQLQELILNDNQLIQLDVNAFRGLHGLLELQL 225
            |:......:..|..|:|..|.|.:....|   .|:||:|.|:.|.:..:...||.|:..|..|.|
  Rat   209 LQPALFCGLGELRELDLSRNALRSVKANVFVHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDL 273

  Fly   226 SGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLH-LQQLDLSGNRIRLLFDNQ 289
            |.||::.:..:||..|..|..|.|:.||:.:|||..|..     || |::|.|..||||.|.:..
  Rat   274 SHNRVAGLMEDTFPGLLGLHVLRLAHNAIASLRPRTFKD-----LHFLEELQLGHNRIRQLGERT 333

  Fly   290 FRVLARLQML------------------------DVSRNSIASLSPAHFVGLGSLRKLYLQYNAI 330
            |..|.:|::|                        ::|.|.:.||....|.||..|..|:|:::.:
  Rat   334 FEGLGQLEVLTLNDNQITEVRVGAFSGLFNVAVMNLSGNCLRSLPERVFQGLDKLHSLHLEHSCL 398

  Fly   331 LEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLE 395
            ..::..|||.|..|..|.|..|::..:|||...|  |..:..|:|..||:.||....|..|..||
  Rat   399 GHVRLHTFAGLSGLRRLFLRDNSISSIEEQSLAG--LSELLELDLTTNRLTHLPRQLFQGLGHLE 461

  Fly   396 YLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRL-TFLAKVN 459
            ||.|.:|:|.:|...:..|::|...|.:.||.||.:...:..||..::.:.:.||.| ||..:
  Rat   462 YLLLSYNQLTTLSAEVLGPLQRAFWLDISHNHLETLAEGLFSSLGRLRYLSLRNNSLQTFSPQ-- 524

  Fly   460 VSFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTG 500
               |.|:|:.::.|||.|.|.:|     |.||  :...|.|
  Rat   525 ---PGLERLWLDANPWDCSCPLK-----ALRD--FALQNPG 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	44/155 (28%)
		LRR_8	104..164	CDD:290566	13/59 (22%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	9/43 (21%)
		LRR_RI	194..455	CDD:238064	93/286 (33%)
		LRR_8	194..254	CDD:290566	22/59 (37%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	23/83 (28%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	9/46 (20%)
		LRR_8	319..380	CDD:290566	19/60 (32%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	21/59 (36%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
Igfals	NP_445781.3	LRRNT	40..78	CDD:214470
		leucine-rich repeat	57..75	CDD:275380
		PLN00113	68..>494	CDD:215061	127/421 (30%)
		LRR 1	75..96
		leucine-rich repeat	79..99	CDD:275380
		LRR 2	99..120		5/15 (33%)
		leucine-rich repeat	103..123	CDD:275380	7/18 (39%)
		LRR 3	123..144		7/20 (35%)
		LRR 4	147..168		7/24 (29%)
		LRR 5	171..192		7/26 (27%)
		leucine-rich repeat	175..195	CDD:275380	7/40 (18%)
		LRR 6	195..216		5/20 (25%)
		leucine-rich repeat	196..219	CDD:275380	4/22 (18%)
		LRR 7	219..240		6/20 (30%)
		leucine-rich repeat	220..243	CDD:275380	6/22 (27%)
		LRR 8	243..264		7/20 (35%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR 9	267..288		8/20 (40%)
		leucine-rich repeat	268..291	CDD:275380	9/22 (41%)
		LRR 10	291..312		9/20 (45%)
		leucine-rich repeat	292..315	CDD:275380	10/27 (37%)
		LRR 11	315..336		9/20 (45%)
		leucine-rich repeat	316..339	CDD:275380	10/22 (45%)
		LRR 12	339..360		2/20 (10%)
		leucine-rich repeat	340..363	CDD:275380	2/22 (9%)
		LRR 13	363..384		5/20 (25%)
		leucine-rich repeat	364..387	CDD:275380	7/22 (32%)
		LRR 14	387..408		5/20 (25%)
		leucine-rich repeat	388..411	CDD:275380	7/22 (32%)
		LRR 15	411..432		7/20 (35%)
		leucine-rich repeat	412..435	CDD:275380	9/24 (38%)
		LRR 16	435..456		7/20 (35%)
		leucine-rich repeat	436..459	CDD:275380	8/22 (36%)
		LRR 17	459..480		8/20 (40%)
		leucine-rich repeat	460..481	CDD:275380	8/20 (40%)
		LRR 18	483..504		6/20 (30%)
		leucine-rich repeat	484..507	CDD:275380	7/22 (32%)
		LRR_8	486..536	CDD:404697	15/54 (28%)
		LRR 19	507..528		6/25 (24%)
		TPKR_C2	535..578	CDD:417692	11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299282at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920