DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lrrc15

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001074151.1	Gene:	lrrc15 / 791200	ZFINID:	ZDB-GENE-031113-8	Length:	564	Species:	Danio rerio

Alignment Length:	388	Identity:	107/388 - (27%)
Similarity:	179/388 - (46%)	Gaps:	56/388 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 INVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYA 157
            :..||  |....||..|..||..|..:..|.|...:||..:..|.|::|:|.......|     |
Zfish    88 VEPHT--FDQAFNLNALGFSGTMLTSLPDNLFQNLTALTTLTLSGNKLEVLPSSLLTPL-----A 145

  Fly   158 NFSHNALKQCDLPHMPLLNRLELGHNRLVNAT---FGVCPQLQELILNDNQLIQLDVNAFRGLHG 219
            |                :|:|:|..|.|.:.:   |....||:.|:|..|.:.||..:.|:||..
Zfish   146 N----------------VNKLDLSKNLLSSLSEDAFRGLDQLEMLMLQRNSIKQLHSSTFQGLSH 194

  Fly   220 LLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRL 284
            |..|.|..|:|:.|....|..|..|..|:|..|.::.|..|:|..|||    |::|.||.||:.|
Zfish   195 LRSLFLQQNQLTDIPAGLFDDLVNLEVLHLQDNKIEQLPANLFAKVQN----LKKLYLSSNRLSL 255

  Fly   285 LFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDL 349
            |....|..|..|..:.:..|.::.|.|..| |..:|::|:|..|.:..::...|:.|.|:..|.:
Zfish   256 LPSGIFLSLPNLTHISLYDNRLSRLMPETF-GTMALQELWLYDNLLTHLEENVFSNLTNIRLLVI 319

  Fly   350 SYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAP 414
            |.|.::::....|.|  |..::.::|:.||:.::.|..|..||.|..:.:.:|::|.:.:::...
Zfish   320 SRNRIQYISPGAFNG--LKELKEVSLHTNRLTNIEPGIFRGLPNLANISIENNQIKQIPIQLLDG 382

  Fly   415 MRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQC 477
            :.||..|.:.:|.|:.:..|.|.:||.|:.::                       :..|||:|
Zfish   383 VSRLSLLEMQNNSLQNLPKDFLNTLSIVENVI-----------------------LHENPWRC 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	45/155 (29%)
		LRR_8	104..164	CDD:290566	17/59 (29%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	8/43 (19%)
		LRR_RI	194..455	CDD:238064	77/260 (30%)
		LRR_8	194..254	CDD:290566	22/59 (37%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	20/58 (34%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	15/60 (25%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	6/24 (25%)
		LRR_8	368..428	CDD:290566	14/59 (24%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	3/22 (14%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
lrrc15	NP_001074151.1	LRRNT	21..48	CDD:214470
		leucine-rich repeat	53..73	CDD:275380
		LRR_RI	<163..253	CDD:238064	34/93 (37%)
		LRR_8	170..229	CDD:290566	22/58 (38%)
		leucine-rich repeat	171..194	CDD:275380	9/22 (41%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		LRR_8	218..277	CDD:290566	22/62 (35%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR_4	241..280	CDD:289563	14/42 (33%)
		leucine-rich repeat	243..266	CDD:275380	10/22 (45%)
		leucine-rich repeat	267..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..372	CDD:290566	16/61 (26%)
		leucine-rich repeat	314..337	CDD:275380	6/24 (25%)
		leucine-rich repeat	338..361	CDD:275380	6/22 (27%)
		leucine-rich repeat	362..385	CDD:275380	3/22 (14%)
		TPKR_C2	418..467	CDD:301599	4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910