DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lrrn3

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001072526.1	Gene:	lrrn3 / 779981	XenbaseID:	XB-GENE-490955	Length:	706	Species:	Xenopus tropicalis

Alignment Length:	415	Identity:	98/415 - (23%)
Similarity:	163/415 - (39%)	Gaps:	99/415 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 NLLDLDLTGAAPINVHTNGFSI---LPNLRQ-LNLSGCGLVDIRGNHFAPESALQRIDFSHNQME 141
            |.|||              :|:   ||...| |.|....:.:|:.....|.: |..:|.|.|.:.
Frog    56 NALDL--------------YSVPDKLPAKTQILLLQANNIEEIKNTDHFPVN-LTGLDLSQNNLS 105

  Fly   142 LLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQL 206
            |:....|.|:.:::......|.|.:                  |:..:|.....||||.:|.|.:
Frog   106 LIANINFTNMHQILSVYLEENKLTE------------------LMEGSFSGLENLQELYINHNLI 152

  Fly   207 IQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNF--V 269
            ..:...||.|:..||.|.|:.|||..|....|:.:..|..|.:.:|      |.|.....||  :
Frog   153 SVISPKAFAGVSNLLRLHLNSNRLQMINSMWFEAIPNLEILMIGEN------PIVNIEDMNFKPL 211

  Fly   270 LHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIK 334
            ::|:.|.|:|..:..:.||.|..|.:|:.:....|....:.......:.:|:.|.|..|.:..|:
Frog   212 INLRSLVLAGVNLTEIPDNAFLGLDKLESISFYDNKFIHVPSVALQKVVNLKFLDLNKNPVRRIQ 276

  Fly   335 PATFAALLNLDTLDLSYNNL-EFLEEQIFGGNTLPRMRRLNLNGN-RMKHLHPLAFSSLPFLEYL 397
            ...|:.:|:|.  :|..||: |.:.........||.:|::....| ::.::||.||..||.||.|
Frog   277 RGDFSNMLHLK--ELGINNMPELVSIDSLAIENLPELRKIEATNNPKLAYIHPNAFYRLPKLETL 339

  Fly   398 KLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSF 462
            .|..|                                   |||::....::            :.
Frog   340 MLNSN-----------------------------------SLSAIYRSTIE------------AL 357

  Fly   463 PNLKRVAIEGNPWQCPCFVKLQHWL 487
            ||||.::|..||.:|.|.::   |:
Frog   358 PNLKEISIHSNPMRCDCVIR---WI 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	39/153 (25%)
		LRR_8	104..164	CDD:290566	14/60 (23%)
		leucine-rich repeat	106..129	CDD:275380	5/23 (22%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	4/40 (10%)
		LRR_RI	194..455	CDD:238064	65/264 (25%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	14/58 (24%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	2/22 (9%)
		LRR_8	319..380	CDD:290566	16/62 (26%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	6/25 (24%)
		LRR_8	368..428	CDD:290566	14/60 (23%)
		leucine-rich repeat	370..393	CDD:275380	7/23 (30%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	2/22 (9%)
lrrn3	NP_001072526.1	leucine-rich repeat	52..70	CDD:275380	7/27 (26%)
		leucine-rich repeat	71..93	CDD:275380	5/21 (24%)
		leucine-rich repeat	94..117	CDD:275380	7/22 (32%)
		leucine-rich repeat	118..141	CDD:275380	4/40 (10%)
		LRR_8	120..176	CDD:290566	18/73 (25%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		LRR_8	164..221	CDD:290566	19/62 (31%)
		leucine-rich repeat	166..189	CDD:275380	9/22 (41%)
		leucine-rich repeat	190..213	CDD:275380	7/28 (25%)
		LRR_8	213..272	CDD:290566	14/58 (24%)
		leucine-rich repeat	214..237	CDD:275380	8/22 (36%)
		leucine-rich repeat	238..261	CDD:275380	2/22 (9%)
		leucine-rich repeat	262..285	CDD:275380	6/22 (27%)
		leucine-rich repeat	286..310	CDD:275380	6/25 (24%)
		LRR_8	309..370	CDD:290566	23/107 (21%)
		leucine-rich repeat	311..333	CDD:275380	6/21 (29%)
		leucine-rich repeat	336..359	CDD:275378	8/69 (12%)
		leucine-rich repeat	360..372	CDD:275378	5/11 (45%)
		TPKR_C2	368..419	CDD:301599	5/15 (33%)
		I-set	429..513	CDD:254352
		IGc2	437..503	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910