DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Cpn2

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	521	Identity:	148/521 - (28%)
Similarity:	217/521 - (41%)	Gaps:	104/521 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WVLPLLLWLLCMGFPILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQTELEVG 71
            ||..|||..|....|:  |   |...| |...||:    :.|.|:
Mouse     9 WVSLLLLARLTQPCPV--G---CDCFG-REVFCSD----EQLADI-------------------- 43

  Fly    72 SGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFS 136
               ..|...::.|:.....|...|.|..||..||                        |.::.|.
Mouse    44 ---PPDIPPHITDIVFVETAFTTVRTRAFSGSPN------------------------LTKVVFL 81

  Fly   137 HNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNAT---FGVCPQLQE 198
            :.|:..|:.|.||.|                     |.|..||:..:.:.|.:   |.....|::
Mouse    82 NTQVRHLEPDAFGGL---------------------PRLQDLEITGSPVSNLSAHIFSNLSSLEK 125

  Fly   199 LILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFG 263
            |.|:.::|..|..:.|..:..|..|||.||:|.::....||.|..||.|||:||.|..|....|.
Mouse   126 LTLDFDRLAGLPEDLFCHMDILESLQLQGNQLRTLPGRLFQSLRDLRTLNLAQNLLTQLPKGAFQ 190

  Fly   264 AVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYN 328
            ::..    ||.|.||.|.:..|.:.....|:.||.|.:..|:|..|||..|..|.||..|:||:|
Mouse   191 SLTG----LQMLKLSNNMLARLPEGALGSLSSLQELFLDGNAITELSPHLFSQLFSLEMLWLQHN 251

  Fly   329 AILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPF 393
            ||..:..:.|::|.||..|.|..|.|..|.|.:|..|  ..:..|:|:.|:::.:...||::|..
Mouse   252 AICHLPVSLFSSLHNLTFLSLKDNALRTLPEGLFAHN--QGLLHLSLSYNQLETIPEGAFTNLSR 314

  Fly   394 LEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLA-- 456
            |..|.|.||.:..|...:|..:.:|.||.|..|.|..::..:..:||.:|.:.:..|:||.|.
Mouse   315 LVSLTLSHNAITDLPEHVFRNLEQLVKLSLDSNNLTALHPALFHNLSRLQLLNLSRNQLTTLPGG 379

  Fly   457 --KVNVSFPNLKRVAIEGNPWQCPCFVK-LQHWLATRDVVYLRDNT-----GYYKGERPLCIVTN 513
              ..|....||   |:.||||||.|.:. |..||...:......:|     .|.||:    :|.|
Mouse   380 IFDTNYDLFNL---ALLGNPWQCDCHLSYLTSWLRLYNNQISNTHTFCAGPAYLKGQ----LVPN 437

  Fly   514 V 514
            :
Mouse   438 L 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	40/155 (26%)
		LRR_8	104..164	CDD:290566	10/59 (17%)
		leucine-rich repeat	106..129	CDD:275380	0/22 (0%)
		leucine-rich repeat	130..153	CDD:275380	8/22 (36%)
		leucine-rich repeat	154..195	CDD:275380	6/43 (14%)
		LRR_RI	194..455	CDD:238064	89/260 (34%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		leucine-rich repeat	244..267	CDD:275380	10/22 (45%)
		LRR_8	271..330	CDD:290566	24/58 (41%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR_8	319..380	CDD:290566	23/60 (38%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	18/59 (31%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470	10/63 (16%)
		LRR_8	73..133	CDD:290566	19/104 (18%)
		leucine-rich repeat	75..98	CDD:275380	8/43 (19%)
		LRR 1	98..119		5/20 (25%)
		leucine-rich repeat	99..122	CDD:275380	5/22 (23%)
		LRR_8	121..181	CDD:290566	23/59 (39%)
		LRR 2	122..143		6/20 (30%)
		leucine-rich repeat	123..146	CDD:275380	6/22 (27%)
		LRR 3	146..167		8/20 (40%)
		leucine-rich repeat	147..170	CDD:275380	10/22 (45%)
		LRR_RI	149..374	CDD:238064	80/230 (35%)
		LRR 4	170..191		10/20 (50%)
		LRR_8	171..229	CDD:290566	22/61 (36%)
		leucine-rich repeat	171..194	CDD:275380	10/22 (45%)
		LRR 5	194..215		7/24 (29%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		LRR_8	217..277	CDD:290566	25/59 (42%)
		LRR 6	218..239		9/20 (45%)
		leucine-rich repeat	219..242	CDD:275380	10/22 (45%)
		LRR 7	242..263		9/20 (45%)
		leucine-rich repeat	243..266	CDD:275380	9/22 (41%)
		LRR_8	266..325	CDD:290566	21/60 (35%)
		LRR 8	266..287		9/20 (45%)
		leucine-rich repeat	267..290	CDD:275380	9/24 (38%)
		LRR 9	290..311		5/20 (25%)
		leucine-rich repeat	291..314	CDD:275380	6/22 (27%)
		LRR_8	313..373	CDD:290566	17/59 (29%)
		LRR 10	314..335		7/20 (35%)
		leucine-rich repeat	315..338	CDD:275380	7/22 (32%)
		LRR 11	338..359		6/20 (30%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
		LRR 12	362..383		5/20 (25%)
		leucine-rich repeat	363..382	CDD:275380	5/18 (28%)
		LRRCT	395..436	CDD:214507	13/44 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910