DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Tril

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_080093.1	Gene:	Tril / 66873	MGIID:	1914123	Length:	809	Species:	Mus musculus

Alignment Length:	398	Identity:	122/398 - (30%)
Similarity:	180/398 - (45%)	Gaps:	53/398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRK----------LIYA---NFS 160
            |.:.||.....|.....||    |.|..|.|..|........:.|          |.|:   ||.
Mouse    11 LVVCGCLAFPPRAESVCPE----RCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGGNFI 71

  Fly   161 HNALKQCDLPHMPLLNRLELGHNRLVN---ATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLE 222
            .| :...|...:..|.||:|.:|::.:   .||....:|:||.|.:|.|..|.......|..|..
Mouse    72 TN-ITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALVPGTLAPLRKLRI 135

  Fly   223 LQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFV-LHLQQLDLSGNRIRLLF 286
            |..:||.:..:...:|:.|..|.||.|..|.|.||...||..:.|.: |||:     .||||.|.
Mouse   136 LYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLE-----SNRIRFLG 195

  Fly   287 DNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSY 351
            .|.|..|.:|:.|::|.|   .|.|       |||            ..|||..|.:|.||.||.
Mouse   196 KNAFSQLGKLRFLNLSAN---ELQP-------SLR------------HAATFVPLRSLSTLILSA 238

  Fly   352 NNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMR 416
            |:|:.|..::|  ..|||:..|:|:||::.||.|.||..|..|..|:|..|.|..|.:.:..|:.
Mouse   239 NSLQHLGPRVF--QHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLH 301

  Fly   417 RLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLA-KVNVSFPNLKRVAIEGNPWQCPCF 480
            .|:.|.|..|.|..::.........::|:.:.:|.|:.|: .:..:.|.|.|:.::||.|.|.|.
Mouse   302 SLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGNGWTCDCR 366

  Fly   481 VK-LQHWL 487
            :: |:.|:
Mouse   367 LRGLKRWM 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	45/162 (28%)
		LRR_8	104..164	CDD:290566	17/67 (25%)
		leucine-rich repeat	106..129	CDD:275380	6/19 (32%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	13/46 (28%)
		LRR_RI	194..455	CDD:238064	86/261 (33%)
		LRR_8	194..254	CDD:290566	19/59 (32%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	6/22 (27%)
		leucine-rich repeat	244..267	CDD:275380	10/22 (45%)
		LRR_8	271..330	CDD:290566	19/58 (33%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	23/60 (38%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	23/59 (39%)
		leucine-rich repeat	370..393	CDD:275380	10/22 (45%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
Tril	NP_080093.1	LRR_RI	<11..194	CDD:238064	57/192 (30%)
		leucine-rich repeat	37..57	CDD:275378	3/19 (16%)
		LRR 1	61..81		6/20 (30%)
		LRR_8	84..143	CDD:290566	19/58 (33%)
		LRR 2	84..105		7/20 (35%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR 3	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR 4	132..153		5/20 (25%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		LRR_8	156..215	CDD:290566	26/66 (39%)
		LRR 5	156..177		10/20 (50%)
		leucine-rich repeat	157..180	CDD:275380	10/22 (45%)
		LRR 6	180..201		11/25 (44%)
		leucine-rich repeat	181..204	CDD:275380	11/27 (41%)
		LRR 7	204..223		9/40 (23%)
		leucine-rich repeat	205..230	CDD:275380	13/46 (28%)
		LRR_RI	229..>364	CDD:238064	44/136 (32%)
		LRR_8	229..289	CDD:290566	26/61 (43%)
		LRR 8	230..251		9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	10/24 (42%)
		LRR 9	254..275		10/20 (50%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		LRR 10	278..298		6/19 (32%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	302..359	CDD:290566	12/56 (21%)
		LRR 11	302..323		5/20 (25%)
		leucine-rich repeat	303..323	CDD:275380	5/19 (26%)
		LRR 12	326..347		4/20 (20%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		TPKR_C2	359..406	CDD:301599	6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..563
		FN3	587..659	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11342
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940