DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and LRRC4

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_071426.1 Gene:LRRC4 / 64101 HGNCID:15586 Length:653 Species:Homo sapiens


Alignment Length:383 Identity:102/383 - (26%)
Similarity:142/383 - (37%) Gaps:102/383 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   199 LILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFG 263
            |:.|:.|:||.|  .||.||.|..|||..|.:..|.:..|..||.|..|.|..|.|..:....| 
Human    82 LMENNIQMIQAD--TFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAF- 143

  Fly   264 AVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYN 328
               .::..|::|.|..|.|..:....|..:..|..||                ||.|:|  |:| 
Human   144 ---EYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLD----------------LGELKK--LEY- 186

  Fly   329 AILEIKPATFAALLNLDTLDLSYNNLE---------FLEEQIFGGNTLPRMRRLNLNG-NRMKHL 383
                |....|..|.||..|:|...|::         .|||....||..|.:|..:.:| :.:|.|
Human   187 ----ISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKL 247

  Fly   384 HPL----------AFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLES 438
            ..:          ||..|..|..|.|.||.|.||...:|.|:|.|.:|||.||.. ..:.|:|..
Human   248 WVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPW-NCDCDILWL 311

  Fly   439 LSSVQEILVDNN------------RLTFLAKV-------------------NVSFPNLKRVAIEG 472
            ...::|.:..|:            |..:|.:|                   |:|...:..:....
Human   312 AWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRT 376

  Fly   473 NP-----WQCPCFVKLQHWLATRDVVYLRD-----------NTGYYKGERPLCIVTNV 514
            .|     |..|....|.|......:..|.|           :||.|     .|:||||
Human   377 PPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVY-----TCMVTNV 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 24/56 (43%)
LRR_8 104..164 CDD:290566
leucine-rich repeat 106..129 CDD:275380
leucine-rich repeat 130..153 CDD:275380
leucine-rich repeat 154..195 CDD:275380
LRR_RI 194..455 CDD:238064 83/287 (29%)
LRR_8 194..254 CDD:290566 23/54 (43%)
leucine-rich repeat 196..219 CDD:275380 9/19 (47%)
leucine-rich repeat 220..243 CDD:275380 8/22 (36%)
leucine-rich repeat 244..267 CDD:275380 6/22 (27%)
LRR_8 271..330 CDD:290566 15/58 (26%)
leucine-rich repeat 272..295 CDD:275380 6/22 (27%)
leucine-rich repeat 296..319 CDD:275380 4/22 (18%)
LRR_8 319..380 CDD:290566 20/70 (29%)
leucine-rich repeat 320..343 CDD:275380 7/22 (32%)
leucine-rich repeat 344..369 CDD:275380 9/33 (27%)
LRR_8 368..428 CDD:290566 25/70 (36%)
leucine-rich repeat 370..393 CDD:275380 7/33 (21%)
leucine-rich repeat 394..417 CDD:275380 10/22 (45%)
leucine-rich repeat 418..441 CDD:275380 8/22 (36%)
LRRC4NP_071426.1 LRRNT 46..79 CDD:214470
LRR <74..291 CDD:227223 71/237 (30%)
LRR 1 76..97 7/16 (44%)
leucine-rich repeat 77..100 CDD:275380 9/19 (47%)
LRR 2 100..121 7/20 (35%)
leucine-rich repeat 101..124 CDD:275380 8/22 (36%)
LRR 3 124..145 6/24 (25%)
leucine-rich repeat 125..148 CDD:275380 6/26 (23%)
LRR 4 148..169 6/20 (30%)
leucine-rich repeat 149..172 CDD:275380 6/22 (27%)
LRR 5 172..194 11/44 (25%)
leucine-rich repeat 173..197 CDD:275380 12/46 (26%)
LRR 6 197..218 5/20 (25%)
leucine-rich repeat 198..219 CDD:275380 4/20 (20%)
LRR 7 219..240 7/20 (35%)
leucine-rich repeat 220..243 CDD:275380 8/22 (36%)
LRR 8 243..264 4/20 (20%)
leucine-rich repeat 244..267 CDD:275380 5/22 (23%)
LRR 9 267..288 9/20 (45%)
leucine-rich repeat 268..289 CDD:275380 9/20 (45%)
LRRCT 300..351 CDD:214507 8/51 (16%)
IG 359..441 CDD:214652 17/76 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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