DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6749 and NYX

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_001365406.2 Gene:NYX / 60506 HGNCID:8082 Length:476 Species:Homo sapiens


Alignment Length:295 Identity:85/295 - (28%)
Similarity:133/295 - (45%) Gaps:36/295 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 LELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGN-RIRL 284
            :.:.|..|.|..:|...|..|..||:|:|..|.|..:.|..|..:.    .|.:|.|:.| .:|.
Human    60 VSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLP----RLAELRLAHNGDLRY 120

  Fly   285 LFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDL 349
            |....|..|:||:.||::...:.|:.......|.:||:| ..::.:....|.....|.||....|
Human   121 LHARTFAALSRLRRLDLAACRLFSVPERLLAELPALREL-AAFDNLFRRVPGALRGLANLTHAHL 184

  Fly   350 SYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAP 414
            ....:|.:......|  |.|:|.|:|..||::.:|..||.....||:|.|..|.|..|....|..
Human   185 ERGRIEAVASSSLQG--LRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRG 247

  Fly   415 MRRLQKLHLGHNLLEEI---------NLDVL---------------ESLSSVQEILVDNNRLTFL 455
            :|||:.|:||.|.|:.:         .|::|               ::||.:..:.::.||||.|
Human   248 LRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVL 312

  Fly   456 AKVNVSFPN--LKRVAIEGNPWQCPCFVK-LQHWL 487
            |.|... |.  |.|:.:..|||.|.|.:: |:.|:
Human   313 AWVAFQ-PGFFLGRLFLFRNPWCCDCRLEWLRDWM 346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 12/34 (35%)
LRR_8 104..164 CDD:290566
leucine-rich repeat 106..129 CDD:275380
leucine-rich repeat 130..153 CDD:275380
leucine-rich repeat 154..195 CDD:275380
LRR_RI 194..455 CDD:238064 72/258 (28%)
LRR_8 194..254 CDD:290566 11/32 (34%)
leucine-rich repeat 196..219 CDD:275380
leucine-rich repeat 220..243 CDD:275380 6/21 (29%)
leucine-rich repeat 244..267 CDD:275380 8/22 (36%)
LRR_8 271..330 CDD:290566 17/59 (29%)
leucine-rich repeat 272..295 CDD:275380 8/23 (35%)
leucine-rich repeat 296..319 CDD:275380 5/22 (23%)
LRR_8 319..380 CDD:290566 16/60 (27%)
leucine-rich repeat 320..343 CDD:275380 5/22 (23%)
leucine-rich repeat 344..369 CDD:275380 5/24 (21%)
LRR_8 368..428 CDD:290566 24/59 (41%)
leucine-rich repeat 370..393 CDD:275380 8/22 (36%)
leucine-rich repeat 394..417 CDD:275380 8/22 (36%)
leucine-rich repeat 418..441 CDD:275380 9/46 (20%)
NYXNP_001365406.2 LRR_8 61..115 CDD:404697 17/57 (30%)
leucine-rich repeat 63..82 CDD:275380 6/18 (33%)
leucine-rich repeat 83..106 CDD:275380 8/26 (31%)
leucine-rich repeat 107..131 CDD:275380 8/23 (35%)
leucine-rich repeat 132..155 CDD:275380 5/22 (23%)
PPP1R42 150..310 CDD:411060 43/162 (27%)
leucine-rich repeat 156..178 CDD:275380 5/22 (23%)
leucine-rich repeat 179..202 CDD:275380 5/24 (21%)
leucine-rich repeat 203..226 CDD:275380 8/22 (36%)
LRR_8 227..285 CDD:404697 18/57 (32%)
leucine-rich repeat 227..250 CDD:275380 8/22 (36%)
leucine-rich repeat 251..274 CDD:275380 6/22 (27%)
leucine-rich repeat 275..296 CDD:275380 2/20 (10%)
leucine-rich repeat 323..335 CDD:275378 5/11 (45%)
LRRCT 331..>365 CDD:214507 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.