DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Pidd1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_073145.1	Gene:	Pidd1 / 57913	MGIID:	1889507	Length:	915	Species:	Mus musculus

Alignment Length:	365	Identity:	99/365 - (27%)
Similarity:	143/365 - (39%)	Gaps:	89/365 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LDLTGAAPINVHTNGFSILPNLRQLNL----SGCGLVDIRGNHFAPESALQRIDF----SHNQME 141
            |:...|.|      |...||...||||    .||..:....:...|:  |.:::|    :|...:
Mouse    25 LEAVDAGP------GAPFLPAGNQLNLDLRPGGCHRLQYLCSQQPPQ--LLQVEFLRLSTHEDPQ 81

  Fly   142 LLDRDFFG-------NLRKLIY-ANFSHNALKQC----------DLPHMPLLNRLELGHNRLVNA 188
            ||| |...       .||.|:. ...|..||..|          .|..:..|..|:|..|||  .
Mouse    82 LLD-DTLAKVPWSLLRLRSLVLKGGQSRGALGACLHGTLTTLPAGLSDLACLAHLDLSFNRL--E 143

  Fly   189 TFGVC-PQ---LQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNL 249
            |...| |:   |..|:|:.|.|.:|. .|...|..|..|.::.|||..:.| |...|:.|::|:|
Mouse   144 TLPTCVPELHGLDALLLSHNHLSELP-EALGALPALTFLTVTHNRLERLPL-TLGSLSTLQRLDL 206

  Fly   250 SQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHF 314
            |:|.||.: |:..|.:::    |.:|:|:.||::.|                         ||..
Mouse   207 SENLLDTI-PSEIGNLRS----LSELNLASNRLQSL-------------------------PASL 241

  Fly   315 VGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNR 379
            .||.|||.|.|..|.:..: |.....|..:..|||..|.|..|..::...   |.:|   |.||.
Mouse   242 AGLRSLRLLVLHSNLLTSV-PTGLVHLPLITRLDLRDNRLRDLPAELLDA---PFVR---LQGNP 299

  Fly   380 MKHLHPLA-----FSSLPFLEYLKLGHNELKSLDVRMFAP 414
            :....|..     .|.:|.:..|.|    ...||..:..|
Mouse   300 LGEASPAPPSPPDISQVPEMPRLLL----TSDLDSFLVTP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	55/182 (30%)
		LRR_8	104..164	CDD:290566	19/75 (25%)
		leucine-rich repeat	106..129	CDD:275380	7/26 (27%)
		leucine-rich repeat	130..153	CDD:275380	8/33 (24%)
		leucine-rich repeat	154..195	CDD:275380	14/52 (27%)
		LRR_RI	194..455	CDD:238064	63/229 (28%)
		LRR_8	194..254	CDD:290566	22/62 (35%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	16/58 (28%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		LRR_8	319..380	CDD:290566	19/60 (32%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	6/24 (25%)
		LRR_8	368..428	CDD:290566	13/52 (25%)
		leucine-rich repeat	370..393	CDD:275380	6/27 (22%)
		leucine-rich repeat	394..417	CDD:275380	5/21 (24%)
		leucine-rich repeat	418..441	CDD:275380
Pidd1	NP_073145.1	LRR 1	131..152		9/22 (41%)
		LRR_RI	<132..295	CDD:238064	60/203 (30%)
		LRR_8	132..188	CDD:290566	20/58 (34%)
		leucine-rich repeat	132..154	CDD:275380	9/23 (39%)
		LRR 2	154..176		7/22 (32%)
		leucine-rich repeat	155..177	CDD:275380	8/22 (36%)
		LRR_8	176..234	CDD:290566	21/63 (33%)
		LRR 3	177..199		7/22 (32%)
		leucine-rich repeat	178..200	CDD:275380	8/22 (36%)
		LRR 4	200..221		9/21 (43%)
		leucine-rich repeat	201..223	CDD:275380	9/22 (41%)
		LRR_8	222..280	CDD:290566	22/87 (25%)
		LRR 5	223..245		9/50 (18%)
		leucine-rich repeat	224..246	CDD:275380	10/46 (22%)
		LRR 6	246..268		7/22 (32%)
		leucine-rich repeat	247..269	CDD:275380	7/22 (32%)
		LRR 7	269..290		6/20 (30%)
		leucine-rich repeat	270..289	CDD:275380	6/18 (33%)
		ZU5	330..403	CDD:295340	1/6 (17%)
		Peptidase_S68	426..458	CDD:287439
		Peptidase S68. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00485	428..457
		ZU5	469..542	CDD:295340
		Peptidase S68. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00485	571..599
		UPA domain. /evidence=ECO:0000250	585..721
		DD	793..878	CDD:301326
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	888..915
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910