DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and LRRC7

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001357714.1	Gene:	LRRC7 / 57554	HGNCID:	18531	Length:	1575	Species:	Homo sapiens

Alignment Length:	362	Identity:	106/362 - (29%)
Similarity:	158/362 - (43%)	Gaps:	79/362 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LANLLDLDLT----------------------GAAPINVHTNGFSILPNLRQLNLSGCGLVDIRG 121
            |.||.:||::                      ...||:...:||:.|.||.||.|:...|
Human   129 LVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFL----- 188

  Fly   122 NHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLP----HMPLLNRLELGH 182
             .|.|.:                   ||.|.||.......|.||  .||    .:..|.||:||:
Human   189 -EFLPAN-------------------FGRLVKLRILELRENHLK--TLPKSMHKLAQLERLDLGN 231

  Fly   183 NRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHG-------LLELQLSGNRLSSIGLETFQP 240
            |.     ||..|::.:.|.|..:| .:|.||.:.|.|       |:.|.:|.||:.::.:: ...
Human   232 NE-----FGELPEVLDQIQNLREL-WMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISG 289

  Fly   241 LAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNS 305
            ...|..|.||.|.|..| |:..|.::.    |..|.:..|::.:| .|....|:.|:..|.|.|.
Human   290 CEALEDLLLSSNMLQQL-PDSIGLLKK----LTTLKVDDNQLTML-PNTIGNLSLLEEFDCSCNE 348

  Fly   306 IASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRM 370
            :.|| |:....|.|||.|.:..|.:.|: |....:..|:..:.|..|.||||.|:|   ..:.::
Human   349 LESL-PSTIGYLHSLRTLAVDENFLPEL-PREIGSCKNVTVMSLRSNKLEFLPEEI---GQMQKL 408

  Fly   371 RRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSL 407
            |.|||:.||:|:| |.:|:.|..|..|.|..|:.|:|
Human   409 RVLNLSDNRLKNL-PFSFTKLKELAALWLSDNQSKAL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	47/163 (29%)
		LRR_8	104..164	CDD:290566	14/59 (24%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	3/22 (14%)
		leucine-rich repeat	154..195	CDD:275380	14/44 (32%)
		LRR_RI	194..455	CDD:238064	70/221 (32%)
		LRR_8	194..254	CDD:290566	19/66 (29%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	5/22 (23%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	19/58 (33%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	21/60 (35%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	17/40 (43%)
		leucine-rich repeat	370..393	CDD:275380	11/22 (50%)
		leucine-rich repeat	394..417	CDD:275380	6/14 (43%)
		leucine-rich repeat	418..441	CDD:275380
LRRC7	NP_001357714.1	leucine-rich repeat	64..85	CDD:275380
		LRR_8	85..140	CDD:338972	5/10 (50%)
		leucine-rich repeat	86..108	CDD:275380
		leucine-rich repeat	109..131	CDD:275380	1/1 (100%)
		LRR	130..440	CDD:227223	102/355 (29%)
		leucine-rich repeat	132..177	CDD:275380	8/44 (18%)
		leucine-rich repeat	178..200	CDD:275380	10/46 (22%)
		leucine-rich repeat	201..223	CDD:275380	6/23 (26%)
		leucine-rich repeat	224..246	CDD:275380	10/26 (38%)
		leucine-rich repeat	247..269	CDD:275380	6/22 (27%)
		leucine-rich repeat	270..292	CDD:275380	5/22 (23%)
		leucine-rich repeat	316..336	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..361	CDD:275380	8/22 (36%)
		leucine-rich repeat	362..384	CDD:275380	6/22 (27%)
		leucine-rich repeat	385..407	CDD:275380	8/24 (33%)
		leucine-rich repeat	408..430	CDD:275380	11/22 (50%)
		PDZ_signaling	1485..1570	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910