DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and LRRC47

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_065761.1 Gene:LRRC47 / 57470 HGNCID:29207 Length:583 Species:Homo sapiens


Alignment Length:243 Identity:80/243 - (32%)
Similarity:114/243 - (46%) Gaps:44/243 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 MPLLNRLEL-GHNRLVNATFGVC---PQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLS- 231
            :|||:.||: |...|.....|:.   |||..|:|..|.|                    |..|| 
Human    49 LPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNAL--------------------GPGLSP 93

  Fly   232 SIGLETFQPLAQLRKLNLSQNALDALRPNV-FGAVQNFVL-HLQQLDLSGNRIRLLFDNQFRVLA 294
            .:|     ||..||.|:||.|||:||.|.. .|..:...| .||.|:|||||:|.|..:..|...
Human    94 ELG-----PLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAP 153

  Fly   295 RLQMLDVSRNSIASLSPAHFVGLGS---LRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEF 356
            |||.|:::.|.:.|. ||.....|:   |.:|....|.:.|:.| ..|.|.:|.|||||.|.|..
Human   154 RLQSLNLTGNCLDSF-PAELFRPGALPLLSELAAADNCLRELSP-DIAHLASLKTLDLSNNQLSE 216

  Fly   357 LEEQIFGGNTLPRMRRLNLNGNRM--KHLHPL--AFSSLPFLEYLKLG 400
            :..::   ...|:::.:|..||::  |.|..:  ...:...||||::|
Human   217 IPAEL---ADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILEYLRVG 261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 29/88 (33%)
LRR_8 104..164 CDD:290566
leucine-rich repeat 106..129 CDD:275380
leucine-rich repeat 130..153 CDD:275380
leucine-rich repeat 154..195 CDD:275380 8/26 (31%)
LRR_RI 194..455 CDD:238064 72/217 (33%)
LRR_8 194..254 CDD:290566 19/60 (32%)
leucine-rich repeat 196..219 CDD:275380 5/22 (23%)
leucine-rich repeat 220..243 CDD:275380 6/23 (26%)
leucine-rich repeat 244..267 CDD:275380 12/23 (52%)
LRR_8 271..330 CDD:290566 23/61 (38%)
leucine-rich repeat 272..295 CDD:275380 11/22 (50%)
leucine-rich repeat 296..319 CDD:275380 7/22 (32%)
LRR_8 319..380 CDD:290566 19/63 (30%)
leucine-rich repeat 320..343 CDD:275380 7/22 (32%)
leucine-rich repeat 344..369 CDD:275380 8/24 (33%)
LRR_8 368..428 CDD:290566 11/37 (30%)
leucine-rich repeat 370..393 CDD:275380 5/26 (19%)
leucine-rich repeat 394..417 CDD:275380 5/7 (71%)
leucine-rich repeat 418..441 CDD:275380
LRRC47NP_065761.1 LRR 44..>239 CDD:227223 73/219 (33%)
leucine-rich repeat 52..76 CDD:275380 6/23 (26%)
LRR 1 76..95 9/38 (24%)
leucine-rich repeat 77..100 CDD:275380 11/47 (23%)
LRR 2 100..121 11/20 (55%)
leucine-rich repeat 101..130 CDD:275380 13/28 (46%)
LRR 3 130..152 11/21 (52%)
leucine-rich repeat 131..154 CDD:275380 11/22 (50%)
LRR 4 154..175 8/21 (38%)
leucine-rich repeat 155..180 CDD:275380 8/25 (32%)
LRR 5 180..202 6/22 (27%)
leucine-rich repeat 181..203 CDD:275380 7/22 (32%)
LRR 6 203..225 8/24 (33%)
leucine-rich repeat 204..226 CDD:275380 8/24 (33%)
LRR 7 226..246 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 260..300 1/2 (50%)
pheT 317..>507 CDD:236592
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 513..544
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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