DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and nyx

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001071085.1	Gene:	nyx / 568821	ZFINID:	ZDB-GENE-061026-3	Length:	469	Species:	Danio rerio

Alignment Length:	321	Identity:	90/321 - (28%)
Similarity:	141/321 - (43%)	Gaps:	50/321 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 LVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNR-LSSIGLETFQPLAQLRKLN 248
            |....||..|.|:.|.|..|.:..:...||:||..|:||:::.|. :..:...||..|.:|.:|:
Zfish    73 LSERAFGTLPSLKTLSLKYNNISFITPGAFKGLPNLVELKMAHNEYIRYLHTRTFTALKRLVRLD 137

  Fly   249 LSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQF-------RVLARLQMLDVSRNSI 306
            ||...|..:...:|         |:|:.|   :..|.|.|.|       |.:..|..:.:.||.|
Zfish   138 LSDCNLFNMPDRIF---------LEQITL---KELLCFQNNFRRVPGALRGMENLTHVYLERNKI 190

  Fly   307 ASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMR 371
            .:::....:||.||:.|.||.|.|..|....|..|:.|:...|:.|.|..|.:|.|.|  |..::
Zfish   191 EAVAYNSLLGLTSLKYLNLQENRINVIHDEAFKDLIRLENFYLNDNLLVDLPQQAFKG--LSNLK 253

  Fly   372 RLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVL 436
            .|||.||.:.::....||.|..||.|.|..|.|..::...|..:..|..|||..|.|..:...|.
Zfish   254 MLNLGGNLLTNVSKTWFSDLVELEVLYLDRNRLSYIEDGSFENLTSLITLHLNSNNLTSLPFSVF 318

  Fly   437 ESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVK-LQHWLAT----RDV 492
            :.:..:                       .|:.:..|||:|.|.:: |:.|:.:    ||:
Zfish   319 QPIYFI-----------------------GRLYLFRNPWECTCDLEWLREWMESYKLVRDI 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	24/71 (34%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	3/9 (33%)
		LRR_RI	194..455	CDD:238064	77/268 (29%)
		LRR_8	194..254	CDD:290566	20/60 (33%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	7/23 (30%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	20/65 (31%)
		leucine-rich repeat	272..295	CDD:275380	8/29 (28%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	24/60 (40%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	20/59 (34%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
nyx	NP_001071085.1	leucine-rich repeat	64..83	CDD:275380	3/9 (33%)
		LRR_8	82..143	CDD:290566	20/60 (33%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..132	CDD:275380	7/23 (30%)
		LRR_RI	<127..311	CDD:238064	61/197 (31%)
		leucine-rich repeat	133..179	CDD:275380	14/57 (25%)
		LRR_8	179..238	CDD:290566	19/58 (33%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		leucine-rich repeat	204..227	CDD:275380	9/22 (41%)
		LRR_8	227..286	CDD:290566	22/60 (37%)
		leucine-rich repeat	228..251	CDD:275380	9/24 (38%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		LRR_8	275..333	CDD:290566	15/80 (19%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		leucine-rich repeat	300..319	CDD:275380	7/18 (39%)
		LRRCT	332..>366	CDD:214507	9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100