DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lrrtm4l2

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_009302017.1	Gene:	lrrtm4l2 / 568695	ZFINID:	ZDB-GENE-080327-14	Length:	557	Species:	Danio rerio

Alignment Length:	429	Identity:	105/429 - (24%)
Similarity:	164/429 - (38%)	Gaps:	125/429 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 TNGFSILPNLRQLNLS-GCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFS 160
            :.||..:|.    |:| ||                |.:...:|.:.||....|.:|.:|::....
Zfish    45 SGGFQDVPE----NISLGC----------------QGLSLRYNSLLLLLPYQFAHLNQLVWLYLD 89

  Fly   161 HNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQL 225
            ||::...|               ||                           ||:||..|.||.|
Zfish    90 HNSISTVD---------------RL---------------------------AFQGLRRLKELIL 112

  Fly   226 SGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQF 290
            |.|:::.:...||:.:..||.|:||.|.:..|.|..|..::.    ||.|.|..|.||.:....|
Zfish   113 SSNKIAQLQNGTFETVPNLRNLDLSYNQMQDLVPGHFHGLRK----LQNLHLRSNNIRSIPVRTF 173

  Fly   291 RVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLE 355
            .....|:.||:..|.:.:::...|:||..|.:|:|::|....|....|..||||..|.|.:|.:
Zfish   174 MECRSLEFLDLGYNRLRTITRTTFLGLLRLTELHLEHNQFSRINFFLFPRLLNLQALYLQWNRI- 237

  Fly   356 FLEEQIFGGN--TLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRL 418
               ..:..|:  |...:::|:|:||.::.|.|..|..||                        .|
Zfish   238 ---RTVVQGSPWTWHTLQKLDLSGNEIQILDPAIFRCLP------------------------NL 275

  Fly   419 QKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQ-----CP 478
            ..|:|..|.:..::|:|:.|..|:..|                  ||     .||.|.     ||
Zfish   276 HTLNLESNKISNVSLEVVSSWISISTI------------------NL-----AGNIWDCSSSICP 317

  Fly   479 CFVKLQHWLATRDVVYLRDNTGYYKGERPLCIVTNVDYC 517
            ....|:::..|||...:.......:|||.:..|.|...|
Zfish   318 LVSWLRNFRGTRDASIICSTPKSLQGERVMDAVRNNSVC 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	35/153 (23%)
		LRR_8	104..164	CDD:290566	14/60 (23%)
		leucine-rich repeat	106..129	CDD:275380	4/23 (17%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	6/40 (15%)
		LRR_RI	194..455	CDD:238064	69/262 (26%)
		LRR_8	194..254	CDD:290566	18/59 (31%)
		leucine-rich repeat	196..219	CDD:275380	4/22 (18%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	19/58 (33%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	19/62 (31%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	6/26 (23%)
		LRR_8	368..428	CDD:290566	13/59 (22%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	0/22 (0%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
lrrtm4l2	XP_009302017.1	LRR_8	<74..117	CDD:290566	18/84 (21%)
		leucine-rich repeat	83..106	CDD:275380	10/64 (16%)
		LRR_8	105..165	CDD:290566	22/63 (35%)
		LRR_RI	107..307	CDD:238064	67/254 (26%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		LRR_8	153..213	CDD:290566	19/63 (30%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..202	CDD:275380	7/22 (32%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		LRR_8	226..285	CDD:290566	20/86 (23%)
		leucine-rich repeat	227..250	CDD:275380	6/26 (23%)
		leucine-rich repeat	251..274	CDD:275380	9/46 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910