DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP007443

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_001687929.1	Gene:	AgaP_AGAP007443 / 5666932	VectorBaseID:	AGAP007443	Length:	415	Species:	Anopheles gambiae

Alignment Length:	429	Identity:	101/429 - (23%)
Similarity:	173/429 - (40%)	Gaps:	105/429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 INVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQ-RIDFSHNQME----LLDR--DFFGN 150
            :|:.|:|::.|.|:                  .|::... |::..|..:.    .|.|  :||..
Mosquito    10 LNMLTDGYTTLRNI------------------PPDTYYSVRVEMLHLPISPSGAFLTRMSEFFSK 56

  Fly   151 LRKLIYANFSHNALKQCDLP--HMPLLNRLELGHNRLVNATFGVCPQLQELIL--NDNQLIQLDV 211
            |...:|    |:.:.|. .|  ::..::.||             .|.:::|::  .||.:.:|.:
Mosquito    57 LELYVY----HDPVFQI-APGTYLSSIHVLE-------------APSMKQLLVGAGDNNVTELII 103

  Fly   212 NAFRGLHGLLELQLSGNRLSSIGLE----TFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHL 272
                               .:.|||    |...|..|..|..::.||.......||  ||  .||
Mosquito   104 -------------------YTCGLERIPQTIGNLPLLEDLTFTECALRNFSLGAFG--QN--RHL 145

  Fly   273 QQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPAT 337
            :.||||.|:|..:......:...::.|.:|.|.:.:|..|.|:||.||..:.|:.|.:.:|....
Mosquito   146 RVLDLSRNQIETIIPTTREMPQAIEYLYLSSNRLENLDMAAFIGLPSLSMIDLRNNNLAKIASQQ 210

  Fly   338 FAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHN 402
            ......::.||:|||.|..::.|..   :.|.::||.|:.|..:.| |......|.|:.|.||.|
Mosquito   211 TVTWSTMEMLDVSYNRLRTIDLQWL---SAPNLKRLILSNNLFEKL-PERLRRFPNLQLLGLGDN 271

  Fly   403 ELKS-LDVRMFAPMRRLQKLHLGHNLLEE-------INLDVLESLSS-----------------V 442
            .|.. :|:.....:..|..:.|.:|...:       |.|.||:||.:                 |
Mosquito   272 RLAGVIDLAPLNGLPELNSIDLSNNPTAKVLRSSRPIRLPVLDSLYAEYCSLNRFNTSGIDLPVV 336

  Fly   443 QEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFV 481
            ..|.:.:|..|.:|.:..:||:::..:...||  .||.|
Mosquito   337 SFISLAHNNFTAVAPLGQAFPSIQSFSFYDNP--IPCSV 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	30/167 (18%)
		LRR_8	104..164	CDD:290566	11/66 (17%)
		leucine-rich repeat	106..129	CDD:275380	1/22 (5%)
		leucine-rich repeat	130..153	CDD:275380	7/29 (24%)
		leucine-rich repeat	154..195	CDD:275380	6/42 (14%)
		LRR_RI	194..455	CDD:238064	74/291 (25%)
		LRR_8	194..254	CDD:290566	12/65 (18%)
		leucine-rich repeat	196..219	CDD:275380	4/24 (17%)
		leucine-rich repeat	220..243	CDD:275380	5/26 (19%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	20/58 (34%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	17/60 (28%)
		leucine-rich repeat	320..343	CDD:275380	4/22 (18%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	18/60 (30%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/23 (30%)
		leucine-rich repeat	418..441	CDD:275380	9/29 (31%)
AgaP_AGAP007443	XP_001687929.1	leucine-rich repeat	99..120	CDD:275380	6/39 (15%)
		LRR_RI	100..296	CDD:238064	59/222 (27%)
		leucine-rich repeat	121..144	CDD:275380	8/26 (31%)
		LRR_8	143..203	CDD:290566	20/59 (34%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		LRR_8	191..250	CDD:290566	17/61 (28%)
		leucine-rich repeat	193..216	CDD:275380	4/22 (18%)
		leucine-rich repeat	217..239	CDD:275380	7/24 (29%)
		LRR_8	238..297	CDD:290566	17/59 (29%)
		leucine-rich repeat	240..262	CDD:275380	6/22 (27%)
		leucine-rich repeat	263..287	CDD:275380	7/23 (30%)
		leucine-rich repeat	288..312	CDD:275380	5/23 (22%)
		leucine-rich repeat	313..335	CDD:275380	3/21 (14%)
		leucine-rich repeat	336..358	CDD:275380	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910