DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and APL1C

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_001688069.1	Gene:	APL1C / 5666907	VectorBaseID:	AGAP007033	Length:	730	Species:	Anopheles gambiae

Alignment Length:	480	Identity:	123/480 - (25%)
Similarity:	191/480 - (39%)	Gaps:	110/480 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SILPNLRQ---LNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHN 162
            ::|.:.||   |||:|..:..|..|.||....:|::....|.:..|....|.|
Mosquito   207 ALLASFRQVEVLNLNGLQIEQIDTNAFAYAHTIQKLYMGFNAIRYLPPYVFQN------------ 259

  Fly   163 ALKQCDLPHMPLLNRLELGHNRLVNATFGV---CPQLQELILNDNQLIQLDVNAFRGLHGLLELQ 224
                     :|||..|.|..|.|.:...|:   .|:|..|.:::|.|.:::.:.|:....|..||
Mosquito   260 ---------VPLLTVLVLERNDLTSLPRGIFHNTPKLSMLSMSNNNLERIEDDTFQATTALQNLQ 315

  Fly   225 LSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQ 289
            ||.|||:.:.|..   :..|..:|:|.|.|..|
Mosquito   316 LSSNRLTHVDLSL---IPSLFHVNVSYNLLSTL-------------------------------- 345

  Fly   290 FRVLARLQMLDVSRNSI-ASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLN---LDTLDLS 350
             .:...::.||.|.||| |...|.:.    .|..|.||:|.:.:.     |.|||   |..:|||
Mosquito   346 -AIPIAVEELDASHNSINAVRGPVNV----ELTILKLQHNNLTDT-----AWLLNYPGLVDVDLS 400

  Fly   351 YNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAP- 414
            ||.||.:..|.|  ..:.|:.||.::.|.:..|: |....:|.|:.|.|.||.|  |.|....|
Mosquito   401 YNQLEKITYQHF--VKMQRLERLYVSNNHLVALN-LYSQPIPTLKVLDLSHNHL--LHVERNQPQ 460

  Fly   415 MRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDN----NRLTFLAKVNVSFPNLKRVAIEGNPW 475
            ..|::.|:|.||.:..:.|....:|.::  .|..|    |.|..|      |.|:...|:.....
Mosquito   461 FDRVEYLYLDHNSIVTLKLSTSHTLKNL--TLSHNDWDCNSLRAL------FRNVAHPAVHDADQ 517

  Fly   476 QCPCFVKLQHWLATRD---------VVYLRDNTGYYKGERP--LCIVTNVDYCIQNLQAVRRLGI 529
            .|....:|:..|..::         :.|:...:...|.:|.  .|..|:....:|:|.  ..:..
Mosquito   518 HCKIDYQLEQGLCCKESDKPYLDRLLQYIALTSVVEKLQRAQGRCSATDTINSVQSLS--HYITQ 580

  Fly   530 LGD--FQG-EQVEADAFDDDASAAQ 551
            .||  .|| ||:||:..:..|...|
Mosquito   581 QGDVPLQGNEQLEAEVNELRAEVQQ 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	44/158 (28%)
		LRR_8	104..164	CDD:290566	15/62 (24%)
		leucine-rich repeat	106..129	CDD:275380	10/25 (40%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	8/43 (19%)
		LRR_RI	194..455	CDD:238064	75/269 (28%)
		LRR_8	194..254	CDD:290566	19/59 (32%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	13/59 (22%)
		leucine-rich repeat	272..295	CDD:275380	0/22 (0%)
		leucine-rich repeat	296..319	CDD:275380	8/23 (35%)
		LRR_8	319..380	CDD:290566	23/63 (37%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	21/60 (35%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	9/23 (39%)
		leucine-rich repeat	418..441	CDD:275380	6/22 (27%)
APL1C	XP_001688069.1	LRR_8	213..273	CDD:290566	21/80 (26%)
		leucine-rich repeat	215..238	CDD:275380	8/22 (36%)
		leucine-rich repeat	239..262	CDD:275380	5/43 (12%)
		LRR_RI	255..503	CDD:238064	85/320 (27%)
		LRR_8	261..321	CDD:290566	20/59 (34%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		leucine-rich repeat	287..310	CDD:275380	5/22 (23%)
		LRR_8	311..361	CDD:290566	19/85 (22%)
		leucine-rich repeat	311..343	CDD:275380	13/34 (38%)
		leucine-rich repeat	351..369	CDD:275380	8/17 (47%)
		LRR_8	371..428	CDD:290566	23/63 (37%)
		leucine-rich repeat	372..393	CDD:275380	9/25 (36%)
		leucine-rich repeat	394..417	CDD:275380	10/24 (42%)
		LRR_8	417..474	CDD:290566	21/59 (36%)
		leucine-rich repeat	418..440	CDD:275380	5/22 (23%)
		leucine-rich repeat	464..487	CDD:275380	6/22 (27%)
		RILP-like	<659..>720	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910