DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and APL1A

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_001688066.1	Gene:	APL1A / 5666905	VectorBaseID:	AGAP007036	Length:	428	Species:	Anopheles gambiae

Alignment Length:	401	Identity:	110/401 - (27%)
Similarity:	160/401 - (39%)	Gaps:	96/401 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LPNLRQ---LNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNAL 164
            |.:.||   |||:|..:.:|..|.||....:|::....|.:..|....|.|:
Mosquito   108 LASFRQVEVLNLNGLQIEEIDTNAFAYAHTIQKLYMGFNAIRYLPPHVFQNV------------- 159

  Fly   165 KQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNR 229
                                         |.|..|:|..|.|..|....|.....|..|.:|.|.
Mosquito   160 -----------------------------PSLTVLVLERNDLTSLPRGIFHNTPKLTMLSMSNNN 195

  Fly   230 LSSIGLETFQPLAQLRKLNLSQNALD----ALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQF 290
            |..|..||||....|:.|.||.|.|.    ||.|::|           .:::|.|.:..|
Mosquito   196 LERIEDETFQATTTLQNLQLSSNRLTHVDLALIPSLF-----------HVNVSYNLLSTL----- 244

  Fly   291 RVLARLQMLDVSRNSI-ASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLN---LDTLDLSY 351
            .:...::.||.|.||| |...|.:.    .|..|.||:|.:.:.     |.|||   |..:||||
Mosquito   245 AIPIAVEELDASHNSINAVRGPVNM----ELTILKLQHNNLTDT-----AWLLNYPGLVEVDLSY 300

  Fly   352 NNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAP-M 415
            |.||.:..:.|  ..:.|:.||.::.||:..|: |....:|.|:.|.|.||.|  |.|....| .
Mosquito   301 NELEKIMYRYF--VKMQRLERLYVSNNRLVALN-LYGQPIPTLKVLDLSHNHL--LHVERNQPQF 360

  Fly   416 RRLQKLHLGHNLLEEINLDVLESLSSVQEILVDN----NRLTFLAKVNVSFPNLKRVAIEGNPWQ 476
            .||:.|:|.||.:..:||....:|.:::  |..|    |.|..|      |.|:.:..::.....
Mosquito   361 DRLENLYLDHNSIVTLNLSTSHTLKNLK--LSHNDWDCNSLRAL------FINVAQPVVDDADQH 417

  Fly   477 CPCFVKLQHWL 487
            |....:|:|.|
Mosquito   418 CKIDYQLEHGL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	40/159 (25%)
		LRR_8	104..164	CDD:290566	15/62 (24%)
		leucine-rich repeat	106..129	CDD:275380	10/25 (40%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	0/40 (0%)
		LRR_RI	194..455	CDD:238064	87/273 (32%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		leucine-rich repeat	244..267	CDD:275380	10/26 (38%)
		LRR_8	271..330	CDD:290566	16/59 (27%)
		leucine-rich repeat	272..295	CDD:275380	3/22 (14%)
		leucine-rich repeat	296..319	CDD:275380	8/23 (35%)
		LRR_8	319..380	CDD:290566	22/63 (35%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	23/60 (38%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	9/23 (39%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
APL1A	XP_001688066.1	LRR_8	112..172	CDD:290566	20/101 (20%)
		leucine-rich repeat	114..137	CDD:275380	8/22 (36%)
		leucine-rich repeat	138..161	CDD:275380	5/64 (8%)
		LRR_RI	160..402	CDD:238064	87/273 (32%)
		LRR_8	160..220	CDD:290566	23/59 (39%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..230	CDD:275380	8/19 (42%)
		leucine-rich repeat	231..255	CDD:275380	5/39 (13%)
		LRR_8	270..327	CDD:290566	22/63 (35%)
		leucine-rich repeat	271..292	CDD:275380	9/25 (36%)
		leucine-rich repeat	293..316	CDD:275380	9/24 (38%)
		LRR_8	316..373	CDD:290566	23/59 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910