DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and APL1B

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_001688067.1	Gene:	APL1B / 5666904	VectorBaseID:	AGAP007035	Length:	554	Species:	Anopheles gambiae

Alignment Length:	497	Identity:	125/497 - (25%)
Similarity:	196/497 - (39%)	Gaps:	128/497 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 NVHTNGFSI------LPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLR 152
            ::|...|::      ...:..|||:|..:.:|..|.||....:|::....|.:..|....|.|
Mosquito    27 SMHLTPFTLSALLASFHKVEVLNLNGLQIEEIDTNAFAYAHTIQKLYMRFNVIRYLPPHVFQN-- 89

  Fly   153 KLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGV---CPQLQELILNDNQLIQLDVNAF 214
                               :|||..|.|..|.|.:...|:   .|:|..|.:::|.|.:::.:.|
Mosquito    90 -------------------VPLLTVLMLDRNDLSSLPPGIFHNTPKLTMLSMSNNNLERIEDDTF 135

  Fly   215 RGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSG 279
            :....|..||||.|||:.:.|..   :..|..:|:|.|.|..|.         ..:.:::||.|.
Mosquito   136 QATTSLQNLQLSSNRLTHVDLAL---IPSLFHVNVSYNLLSTLA---------IPIAVEELDASH 188

  Fly   280 NRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLN- 343
            |.|.::                       ..|.:.    .|..|.||:|.:.:.     |.|||
Mosquito   189 NSINVV-----------------------RGPVNV----ELTILKLQHNNLTDT-----AWLLNY 221

  Fly   344 --LDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFS----SLPFLEYLKLGHN 402
              |..:|||||.||.:....|  .|:.|:.||:::.||:     :||.    .:|.|:.|.|.||
Mosquito   222 PGLTDVDLSYNQLEIITIHHF--VTMQRLERLHVSNNRL-----VAFDLYGRPIPTLKVLDLSHN 279

  Fly   403 ELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDN----NRLTFLAKVNVSFP 463
            .|..::... |...:||.|:|.||.:..:.|....::.::  .|..|    |.|..|      |.
Mosquito   280 HLMWVEHNQ-AQFDKLQYLYLDHNSIVTLKLSTSHTIKNL--TLSHNDWDCNSLRAL------FR 335

  Fly   464 NLKRVAIEGNPWQCPCFVKLQHWLATR--DVVYLRDNTGYY----------KGERPLCIVTNVDY 516
            |:.|..::.....|.....|:|.|..:  |..|| |....|          :...| |..|:...
Mosquito   336 NVARPVVDDADQYCKIDYHLEHGLCCKESDKPYL-DRLLQYIAMTSVVEKQRKNEP-CSATDAIN 398

  Fly   517 CIQNL------QAVRRLGILGDFQG-EQVEADAFDDDASAAQ 551
            ..|:|      |||..|      || ||:||:..:..|...|
Mosquito   399 SAQSLYHYITQQAVVSL------QGNEQLEAEVNELRAEVQQ 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	41/155 (26%)
		LRR_8	104..164	CDD:290566	13/59 (22%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	8/43 (19%)
		LRR_RI	194..455	CDD:238064	72/271 (27%)
		LRR_8	194..254	CDD:290566	19/59 (32%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	11/58 (19%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		leucine-rich repeat	296..319	CDD:275380	1/22 (5%)
		LRR_8	319..380	CDD:290566	23/63 (37%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	21/63 (33%)
		leucine-rich repeat	370..393	CDD:275380	6/26 (23%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
APL1B	XP_001688067.1	LRR_8	44..103	CDD:290566	19/79 (24%)
		leucine-rich repeat	45..68	CDD:275380	8/22 (36%)
		leucine-rich repeat	69..92	CDD:275380	5/43 (12%)
		LRR_8	91..151	CDD:290566	20/59 (34%)
		leucine-rich repeat	93..116	CDD:275380	6/22 (27%)
		LRR_RI	<106..300	CDD:238064	65/245 (27%)
		leucine-rich repeat	117..140	CDD:275380	5/22 (23%)
		leucine-rich repeat	141..161	CDD:275380	9/22 (41%)
		leucine-rich repeat	162..186	CDD:275380	7/32 (22%)
		LRR_8	201..258	CDD:290566	23/63 (37%)
		leucine-rich repeat	202..223	CDD:275380	9/25 (36%)
		leucine-rich repeat	224..247	CDD:275380	10/24 (42%)
		LRR_8	247..304	CDD:290566	21/62 (34%)
		leucine-rich repeat	248..270	CDD:275380	6/26 (23%)
		leucine-rich repeat	294..307	CDD:275378	6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910