DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP007455

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_001687923.1	Gene:	AgaP_AGAP007455 / 5666885	VectorBaseID:	AGAP007455	Length:	477	Species:	Anopheles gambiae

Alignment Length:	321	Identity:	73/321 - (22%)
Similarity:	130/321 - (40%)	Gaps:	85/321 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 LLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRP----NVFGAVQN------------F 268
            :::|:.:.::|..:.:|      ....||:...::.||:|    :||..::.            |
Mosquito    47 IVKLEDANHKLKLVDIE------DKTILNIKGGSIVALQPQHCSSVFAKLEKVSIGRVGLKELCF 105

  Fly   269 VLHLQQLDLSGNRIRLLFDNQFRVLA-RLQMLDVSRNSIASL-SPAHFVGLGSLRKLYLQYNAIL 331
            ......:....||||.|...:....| |:::|.::.|.:.|: |...||   :|::|:|:.||:.
Mosquito   106 APSFVYVSAEHNRIRTLHVPEAAPAAYRVEVLRLNDNQLESVESMRAFV---ALKELHLERNALS 167

  Fly   332 EIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEY 396
            .:..|.||.:..|:.|.|:||                   |||:..:.:..|      |||.|..
Mosquito   168 TLDMACFAEMPKLEKLYLAYN-------------------RLNVIASTVSEL------SLPALSV 207

  Fly   397 LKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVS 461
            |.|.:|.|...|:|.:: :..|:.|.|..|     ||..:..|.:||.
Mosquito   208 LALQNNTLTVFDLRTWS-LPNLELLELSAN-----NLTKVSGLDNVQA----------------- 249

  Fly   462 FPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQ 522
               |..:::.||.|||....::...|...||. ::|......|      :.|...|..:::
Mosquito   250 ---LSDISLAGNRWQCHELDQMLEQLEKNDVT-VKDGDVNCSG------IRNSSICCTHVE 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	5/35 (14%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380
		LRR_RI	194..455	CDD:238064	60/252 (24%)
		LRR_8	194..254	CDD:290566	5/33 (15%)
		leucine-rich repeat	196..219	CDD:275380
		leucine-rich repeat	220..243	CDD:275380	3/22 (14%)
		leucine-rich repeat	244..267	CDD:275380	7/26 (27%)
		LRR_8	271..330	CDD:290566	17/60 (28%)
		leucine-rich repeat	272..295	CDD:275380	6/23 (26%)
		leucine-rich repeat	296..319	CDD:275380	6/23 (26%)
		LRR_8	319..380	CDD:290566	16/60 (27%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	5/24 (21%)
		LRR_8	368..428	CDD:290566	18/59 (31%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
AgaP_AGAP007455	XP_001687923.1	LRR_8	133..190	CDD:290566	20/78 (26%)
		leucine-rich repeat	134..155	CDD:275380	6/23 (26%)
		LRR_RI	<137..330	CDD:238064	55/225 (24%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		LRR_8	178..238	CDD:290566	23/90 (26%)
		leucine-rich repeat	180..204	CDD:275380	11/48 (23%)
		leucine-rich repeat	205..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	228..249	CDD:275380	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910