DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP007469

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_001687915.1	Gene:	AgaP_AGAP007469 / 5666872	VectorBaseID:	AGAP007469	Length:	406	Species:	Anopheles gambiae

Alignment Length:	373	Identity:	100/373 - (26%)
Similarity:	158/373 - (42%)	Gaps:	66/373 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 IYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLD-VNAFRGLH 218
            :|..||...|........|.|.|:.....|:....: ..|..|  :..||.|.::: |||..
Mosquito    20 LYVAFSIEKLIVSSSASGPFLQRIATLTERISYMAY-KDPVFQ--LPADNTLTEIEIVNAVM--- 78

  Fly   219 GLLELQLSGNR-LSSIGLE---------TFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQ 273
             |..|....|| |:.:.:|         |...:.:|.:|.:.|.||.|||.:|.  |.|  ..|.
Mosquito    79 -LRSLVAGTNRHLTRLYVENCLLDRIPPTLSNMIELEELLIMQCALTALRLDVL--VNN--PKLT 138

  Fly   274 QLDLSGNRIRLLF------DNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILE 332
            .:||:.||||.||      .|:..|    ..|.::.|.:..|..:.|..:..|.:..::.|.|:.
Mosquito   139 TIDLTRNRIRQLFPITTPPKNKLSV----TFLSLAANQLERLDMSMFAFMPDLERFDVRGNRIVR 199

  Fly   333 IK---PATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFL 394
            .:   |.|:.:|:.   |.:|.||:...:.:   ..||..:|.:.|:.|.:..| |..:..||.|
Mosquito   200 FEATAPVTYGSLIR---LLVSSNNITQFDTR---NLTLSELRSIYLDDNALTEL-PTHWGKLPKL 257

  Fly   395 EYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEI---------NLDVL--ES---------- 438
            .||....|.||.:|:..||....|..:.:..|::|.|         .||::  ||
Mosquito   258 IYLGFDRNNLKRIDMSFFAKFATLNSVIISENIVETIRTSTPITMPELDIILFESNQIVSVNFTG 322

  Fly   439 --LSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQ 484
              ...:..|.:.|||||.:..:...||. .|:|::|||.:|.....|:
Mosquito   323 CNFPKMNLISLSNNRLTTIPPLFQRFPE-SRLAMDGNPIKCSSMTALK 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	28/111 (25%)
		LRR_8	104..164	CDD:290566	3/8 (38%)
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	8/39 (21%)
		LRR_RI	194..455	CDD:238064	83/303 (27%)
		LRR_8	194..254	CDD:290566	18/70 (26%)
		leucine-rich repeat	196..219	CDD:275380	7/23 (30%)
		leucine-rich repeat	220..243	CDD:275380	7/32 (22%)
		leucine-rich repeat	244..267	CDD:275380	10/22 (45%)
		LRR_8	271..330	CDD:290566	17/64 (27%)
		leucine-rich repeat	272..295	CDD:275380	11/28 (39%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		LRR_8	319..380	CDD:290566	15/63 (24%)
		leucine-rich repeat	320..343	CDD:275380	6/25 (24%)
		leucine-rich repeat	344..369	CDD:275380	6/24 (25%)
		LRR_8	368..428	CDD:290566	18/59 (31%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	8/45 (18%)
AgaP_AGAP007469	XP_001687915.1	LRR_8	88..147	CDD:290566	19/62 (31%)
		leucine-rich repeat	90..112	CDD:275380	3/21 (14%)
		leucine-rich repeat	113..136	CDD:275380	11/26 (42%)
		LRR_8	135..197	CDD:290566	17/65 (26%)
		leucine-rich repeat	137..162	CDD:275380	10/24 (42%)
		leucine-rich repeat	163..186	CDD:275380	5/26 (19%)
		leucine-rich repeat	187..210	CDD:275380	5/22 (23%)
		leucine-rich repeat	211..233	CDD:275380	7/27 (26%)
		LRR_8	232..289	CDD:290566	17/57 (30%)
		leucine-rich repeat	234..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	9/22 (41%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		leucine-rich repeat	305..327	CDD:275380	4/21 (19%)
		leucine-rich repeat	328..350	CDD:275380	7/21 (33%)
		leucine-rich repeat	351..370	CDD:275380	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910