DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and LOC563710

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_692159.4	Gene:	LOC563710 / 563710	-ID:	-	Length:	635	Species:	Danio rerio

Alignment Length:	389	Identity:	104/389 - (26%)
Similarity:	175/389 - (44%)	Gaps:	64/389 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 MPLLNRLELGHNRLVNAT--FG--VCPQLQELILNDNQLIQLDVNAFRGL-----HGLLELQLSG 227
            :|||.:..|      :||  ||  .||:....   |.:::..:.:|||.:     .|...|.|..
Zfish    12 VPLLMQAWL------SATPCFGERPCPRSCRC---DGKIVYCESSAFRDVPKNLSGGCQGLSLRY 67

  Fly   228 NRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRV 292
            |.|:|:....|..|.||..|.|..|.:..:....|..::    .|::|.||.|:|.||.:..|.:
Zfish    68 NSLASLKAGQFVGLNQLIWLYLDHNYIANVDARAFQGIR----RLKELILSSNKITLLHNTTFHL 128

  Fly   293 LARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFL 357
            :..|:.||:|.|.:.:|.|..|.||..|..|:::.|::..:....|....||:.|||.||.|..:
Zfish   129 VPNLRNLDLSYNKLQALQPGQFQGLRKLLSLHMRSNSLKNLPSRLFQDCRNLEFLDLGYNRLRSI 193

  Fly   358 EEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLH 422
            ......|  |.::..|::..|:...::...|.....|..|.|..|.::::...:......||||.
Zfish   194 TRNSMSG--LLKLTELHIEHNQFSKINFFNFPRFYNLRALYLQWNRIRTMSEGLTWMWTSLQKLD 256

  Fly   423 LGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVS------FPNLKRVAIEGNPWQC-PCF 480
            |..|.|:||:.:|..::.::|.:.:|:|:|     ||||      :.:|..:::.||.|.| |..
Zfish   257 LSGNDLQEIDAEVYRAMPNLQTLNLDSNKL-----VNVSQEAVDAWTSLTAISLAGNMWDCGPVV 316

  Fly   481 VKLQHWLATRDVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQAVRRLGILGDFQGEQVEADAFD 544
            ..|..|:.|            ::|.:.:.::     |....:.          |||:| .||.|
Zfish   317 CPLVAWMRT------------FRGNKEINMI-----CASPKEV----------QGEKV-LDAVD 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	27/92 (29%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	9/26 (35%)
		LRR_RI	194..455	CDD:238064	73/265 (28%)
		LRR_8	194..254	CDD:290566	18/64 (28%)
		leucine-rich repeat	196..219	CDD:275380	4/27 (15%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	22/58 (38%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR_8	319..380	CDD:290566	16/60 (27%)
		leucine-rich repeat	320..343	CDD:275380	4/22 (18%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	13/59 (22%)
		leucine-rich repeat	370..393	CDD:275380	3/22 (14%)
		leucine-rich repeat	394..417	CDD:275380	4/22 (18%)
		leucine-rich repeat	418..441	CDD:275380	10/22 (45%)
LOC563710	XP_692159.4	leucine-rich repeat	60..83	CDD:275380	7/22 (32%)
		LRR_RI	<81..286	CDD:238064	60/210 (29%)
		LRR_8	83..142	CDD:290566	20/62 (32%)
		leucine-rich repeat	84..107	CDD:275380	5/26 (19%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	130..190	CDD:290566	21/59 (36%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..179	CDD:275380	4/22 (18%)
		LRR_8	178..238	CDD:290566	17/61 (28%)
		leucine-rich repeat	180..203	CDD:275380	9/24 (38%)
		leucine-rich repeat	204..227	CDD:275380	3/22 (14%)
		leucine-rich repeat	228..251	CDD:275380	4/22 (18%)
		LRR_8	250..308	CDD:290566	19/62 (31%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910