DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and zgc:153913

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001073448.1	Gene:	zgc:153913 / 559700	ZFINID:	ZDB-GENE-061103-397	Length:	496	Species:	Danio rerio

Alignment Length:	407	Identity:	113/407 - (27%)
Similarity:	170/407 - (41%)	Gaps:	64/407 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGN 150
            |...:.|:|:.|       .:|:|.:...|:.|:....|.....|.::.|.:..::.:..:.|..
Zfish    38 DRMKSLPVNIST-------QVRELIVVASGIPDLDQQSFPETLRLSKLVFLNGMLKSVSGEAFER 95

  Fly   151 LRKLIYANFSHNALKQCDLPHMPLLNRLELGHN----RLVNATFGVCPQLQELILNDNQLIQLDV 211
            |.:                     |..||:..|    .|...||.....|..|:||:|:|..:|.
Zfish    96 LVE---------------------LRELEISGNICWMSLDIQTFSSLTNLTRLLLNNNKLSGVDA 139

  Fly   212 NAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLD 276
            ..|..||.|..|||.||.||.:....||.|.:|::|:||.|.:.:|...:|   || ...|:.|.
Zfish   140 GLFHSLHQLEMLQLRGNGLSFLSGRLFQRLHRLQELDLSFNQISSLSTELF---QN-NSELRVLS 200

  Fly   277 LSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAAL 341
            |..|:|..|.|..|..|..||.|::..|.|..|:|..|.  .||:.|.|:.|.:.::..|.|..|
Zfish   201 LQANKIPNLPDGIFTHLDHLQELNLRSNLIRVLTPGSFP--ASLKTLILKKNLLEKLTNAVFHTL 263

  Fly   342 LNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKS 406
            ..:..||||.|:|..:...:|  ..|..:..|:|:.||:..|....|..|..::.:.|..|.|.|
Zfish   264 HYITYLDLSQNSLTEVPADLF--QNLISLETLDLSENRISTLAGSVFKGLFSIKSVYLQKNSLIS 326

  Fly   407 LDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIE 471
            :|..:......||.|.|.:|.|..|.....|.|         :.:..|              .:.
Zfish   327 VDAHLLKDQHDLQLLDLSNNSLRSIPSGFFEDL---------DFQCVF--------------ELR 368

  Fly   472 GNPWQCPCFVK-LQHWL 487
            ||||.|.|.:. ...||
Zfish   369 GNPWSCDCGIHYFYDWL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	42/156 (27%)
		LRR_8	104..164	CDD:290566	9/59 (15%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	7/44 (16%)
		LRR_RI	194..455	CDD:238064	84/260 (32%)
		LRR_8	194..254	CDD:290566	26/59 (44%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	11/22 (50%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	22/58 (38%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	19/60 (32%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	17/59 (29%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	9/22 (41%)
zgc:153913	NP_001073448.1	leucine-rich repeat	75..98	CDD:275380	4/22 (18%)
		LRR_RI	141..>350	CDD:238064	74/216 (34%)
		LRR_8	147..206	CDD:290566	24/62 (39%)
		leucine-rich repeat	148..171	CDD:275380	11/22 (50%)
		leucine-rich repeat	172..195	CDD:275380	9/26 (35%)
		LRR_8	194..252	CDD:290566	22/59 (37%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..241	CDD:275380	8/22 (36%)
		leucine-rich repeat	242..265	CDD:275380	7/22 (32%)
		leucine-rich repeat	266..289	CDD:275380	8/24 (33%)
		LRR_8	267..324	CDD:290566	17/58 (29%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..337	CDD:275380	5/22 (23%)
		leucine-rich repeat	338..359	CDD:275380	8/20 (40%)
		TPKR_C2	370..>404	CDD:301599	7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910