DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Lrrn1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001032440.1	Gene:	Lrrn1 / 500280	RGDID:	1564145	Length:	716	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	102/435 - (23%)
Similarity:	178/435 - (40%)	Gaps:	100/435 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 IRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHN 183
            ::.|:.|     :.:|.......|.:.||..|       ||::  :|:..|.::..|..|.|..|
  Rat    79 LQSNNIA-----KTVDELQQLFNLTELDFSQN-------NFTN--IKEVGLANLTQLTTLHLEEN 129

  Fly   184 RLVNATFGVCPQ----LQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQL 244
            ::...| ..|.|    ||||.:|.||:..:..|||.||..||.|.|:.|:|..|....|.....|
  Rat   130 QISEMT-DYCLQDLSNLQELYINHNQISSISANAFSGLKNLLRLHLNSNKLKVIDSRWFDSTPNL 193

  Fly   245 RKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASL 309
            ..|.:.:|.:..:                 ||::   .|.|.:.:..|||.:.:.|:..|::
  Rat   194 EILMIGENPVIGI-----------------LDMN---FRPLSNLRSLVLAGMYLTDIPGNAL--- 235

  Fly   310 SPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLN 374
                 |||.||..|....|.::::.......:.||..|||:.|.:..::|..|  ..:.|::.|.
  Rat   236 -----VGLDSLESLSFYDNKLIKVPQLALQKVPNLKFLDLNKNPIHKIQEGDF--KNMLRLKELG 293

  Fly   375 LNG-NRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLES 438
            :|. ..:..:...|..:||.|..|:..:|                .||...|.|       ...|
  Rat   294 INNMGELVSVDRYALDNLPELTKLEATNN----------------PKLSYIHRL-------AFRS 335

  Fly   439 LSSVQEILVDNNRLTFLAKVNV-SFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTGYY 502
            :.:::.::::||.|..:.:..| |.|||:.::|..||.:|.|.:   ||        :..|....
  Rat   336 VPALESLMLNNNALNAVYQKTVESLPNLREISIHSNPLRCDCVI---HW--------INSNKTNI 389

  Fly   503 KGERPLCIVTNVDYCIQNLQAVRRLGILGDFQGEQVEADAFDDDA 547
            :...||.:     :|          .:..:::|:||:.....|.:
  Rat   390 RFMEPLSM-----FC----------AMPPEYRGQQVKEVLIQDSS 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	41/140 (29%)
		LRR_8	104..164	CDD:290566	9/44 (20%)
		leucine-rich repeat	106..129	CDD:275380	2/9 (22%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	10/40 (25%)
		LRR_RI	194..455	CDD:238064	65/265 (25%)
		LRR_8	194..254	CDD:290566	24/63 (38%)
		leucine-rich repeat	196..219	CDD:275380	12/22 (55%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	3/22 (14%)
		LRR_8	271..330	CDD:290566	16/58 (28%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		LRR_8	319..380	CDD:290566	15/61 (25%)
		leucine-rich repeat	320..343	CDD:275380	3/22 (14%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	12/60 (20%)
		leucine-rich repeat	370..393	CDD:275380	4/23 (17%)
		leucine-rich repeat	394..417	CDD:275380	3/22 (14%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
Lrrn1	NP_001032440.1	leucine-rich repeat	54..73	CDD:275380
		LRR	<68..372	CDD:227223	88/360 (24%)
		LRR 1	73..95		3/20 (15%)
		leucine-rich repeat	74..96	CDD:275380	3/21 (14%)
		LRR 2	96..117		8/29 (28%)
		leucine-rich repeat	97..120	CDD:275380	8/31 (26%)
		LRR 3	120..141		6/21 (29%)
		leucine-rich repeat	121..144	CDD:275380	7/23 (30%)
		LRR 4	144..165		10/20 (50%)
		leucine-rich repeat	145..168	CDD:275380	12/22 (55%)
		LRR 5	168..189		8/20 (40%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		LRR 6	192..213		5/40 (13%)
		leucine-rich repeat	193..216	CDD:275380	7/42 (17%)
		LRR 7	216..237		5/28 (18%)
		leucine-rich repeat	217..240	CDD:275380	8/30 (27%)
		LRR 8	240..261		4/20 (20%)
		leucine-rich repeat	241..264	CDD:275380	3/22 (14%)
		LRR 9	264..285		8/22 (36%)
		leucine-rich repeat	265..288	CDD:275380	7/24 (29%)
		leucine-rich repeat	289..313	CDD:275380	4/23 (17%)
		leucine-rich repeat	314..335	CDD:275380	7/43 (16%)
		leucine-rich repeat	339..362	CDD:275378	5/22 (23%)
		leucine-rich repeat	363..375	CDD:275378	4/11 (36%)
		LRRCT	371..419	CDD:214507	14/73 (19%)
		I-set	429..516	CDD:400151
		Ig strand A'	433..438	CDD:409353
		Ig strand B	441..450	CDD:409353
		Ig strand C	456..460	CDD:409353
		Ig strand C'	463..465	CDD:409353
		Ig strand D	478..481	CDD:409353
		Ig strand E	482..487	CDD:409353
		Ig strand F	495..503	CDD:409353
		Ig strand G	506..516	CDD:409353
		FN3	531..600	CDD:214495
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910