DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and Lgr6

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	146/593 - (24%)
Similarity:	221/593 - (37%)	Gaps:	154/593 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PLLLWL-LCM----------------GFPILHGADLCQPIG-WRNFQCSEVASLQDLVDLGAENW 56
            ||||.| ||:                |.|.......||..| ..:..|||
  Rat     5 PLLLALCLCVVLCALARAGSDPQPGPGRPACPAPCHCQEDGIMLSADCSE--------------- 54

  Fly    57 HTLAIRNVQTELEVGSGENADHLANLLDL---DLTGAAPINVHTNGFSILPNLRQLNLSGCGLVD 118
              |.:..|..:|        |.|...|||   :||...|...|...|     |.:|.||
  Rat    55 --LGLSEVPADL--------DPLTAYLDLSMNNLTELQPGLFHHLRF-----LEELRLS------ 98

  Fly   119 IRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLP-----HMPLLNRL 178
              |||           .||     :.|..|..|..|.......|.|:  .:|     .:|.|..|
  Rat    99 --GNH-----------LSH-----IPRQAFSGLHSLKILMLQSNQLR--GIPAEALWELPSLQSL 143

  Fly   179 ELGHNRL---VNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQP 240
            .|..|.:   ...:|.....|:.|.|:||.|.::.|.|...|..|..:.|:.||:..|....||.
  Rat   144 RLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRIRHIPDYAFQN 208

  Fly   241 LAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNS 305
            |..|..|:|..|.:..:..:.|..:.|    |:.|||:.|.:: .|....|.|.|||.|....|:
  Rat   209 LTSLVVLHLHNNRIQHVGTHSFEGLHN----LETLDLNYNELQ-EFPVAIRTLGRLQELGFHNNN 268

  Fly   306 IASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLS-------------YNNLEFL 357
            |.::....|:|...|:.::...|.|..:..:.|..|..|.||.|:             ..:||.|
  Rat   269 IKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEIL 333

  Fly   358 EEQIFG--------GNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAP 414
            .....|        ...|||:|.|.|:.|:::.|..|  .....||.:.|.||.:..:....|:.
  Rat   334 TLTRAGIRLLPAGMCQQLPRLRILELSHNQIEELPSL--HRCQKLEEIGLQHNRIWEIGADTFSQ 396

  Fly   415 MRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFL------------AKVNV------- 460
            :..||.|.|..|.:..|:.:...:|.|:.::.:.:|:||.|            .|.|:
  Rat   397 LSSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS 461

  Fly   461 --SFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQA 523
              |||.|:.:.:. ..:||..:....::..|         :|.::.|         |:..:..:|
  Rat   462 KDSFPKLRILEVP-YAYQCCAYGLCANFFKT---------SGQWQAE---------DFHAEEEEA 507

  Fly   524 VRR-LGIL 530
            .:| ||:|
  Rat   508 PKRPLGLL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	43/160 (27%)
		LRR_8	104..164	CDD:290566	14/59 (24%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	10/48 (21%)
		LRR_RI	194..455	CDD:238064	78/281 (28%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	18/58 (31%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	20/81 (25%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..369	CDD:275380	9/45 (20%)
		LRR_8	368..428	CDD:290566	19/59 (32%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470	10/58 (17%)
		LRR_RI	<70..248	CDD:238064	58/213 (27%)
		leucine-rich repeat	70..91	CDD:275380	7/20 (35%)
		LRR_8	92..150	CDD:290566	21/83 (25%)
		leucine-rich repeat	92..115	CDD:275380	12/46 (26%)
		leucine-rich repeat	116..139	CDD:275380	4/24 (17%)
		LRR_8	138..198	CDD:290566	18/59 (31%)
		leucine-rich repeat	140..163	CDD:275380	5/22 (23%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		LRR_8	186..246	CDD:290566	19/63 (30%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..258	CDD:275380	8/22 (36%)
		LRR_RI	253..>442	CDD:238064	50/190 (26%)
		LRR_8	258..314	CDD:290566	17/55 (31%)
		leucine-rich repeat	259..282	CDD:275380	7/22 (32%)
		leucine-rich repeat	283..304	CDD:275380	4/20 (20%)
		LRR_8	305..364	CDD:290566	15/58 (26%)
		leucine-rich repeat	330..344	CDD:275378	4/13 (31%)
		leucine-rich repeat	354..375	CDD:275380	6/22 (27%)
		LRR_8	375..434	CDD:290566	15/58 (26%)
		leucine-rich repeat	376..399	CDD:275380	6/22 (27%)
		leucine-rich repeat	400..421	CDD:275380	6/20 (30%)
		leucine-rich repeat	424..444	CDD:275380	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910