DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and farsb

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001007769.1	Gene:	farsb / 493608	ZFINID:	ZDB-GENE-021206-2	Length:	590	Species:	Danio rerio

Alignment Length:	269	Identity:	60/269 - (22%)
Similarity:	104/269 - (38%)	Gaps:	69/269 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 LQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIAS-----LSPAHFVGLGSLRKLYLQYNAIL 331
            |.::|:..||..||.     :...::.|.|.::.:.:     :|||.  |....|.|..:..|
Zfish    62 LYKIDVPANRYDLLC-----LEGLVRGLQVFKDKMEAPRYKRVSPAD--GGEPQRLLITEETA-- 117

  Fly   332 EIKPATFAALL-NLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLE 395
            .::|...||:| |:......|::...|:|::.  ..:.|.|.|...|.     |.|...|.|| .
Zfish   118 SVRPFAVAAVLRNITFTQERYDSFIELQEKLH--QNICRKRTLVAIGT-----HDLDTISGPF-T 174

  Fly   396 YLKLGHNELKSLDVRMFAPMRRLQKL-------------HLGHNLLEEINLDVLESLSSVQEILV 447
            |......|::      |.|:.:.|:.             ||.|      .|.::|: ..:..|:.
Zfish   175 YTAKAPGEIR------FKPLNQSQEFTATELMSLYKSDSHLRH------YLHIIEN-EPLYPIIY 226

  Fly   448 DNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRDNTGYYKGERPLCIVT 512
            |:|.:.      :|.|.:    |.||      ..|:.  |.|::|......|...|.:..|.::.
Zfish   227 DSNGIV------LSMPPI----INGN------HSKIS--LNTKNVFIECTATDLTKAKITLDMIV 273

  Fly   513 NV--DYCIQ 519
            .:  :||.|
Zfish   274 TMFSEYCEQ 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380
		LRR_RI	194..455	CDD:238064	45/201 (22%)
		LRR_8	194..254	CDD:290566
		leucine-rich repeat	196..219	CDD:275380
		leucine-rich repeat	220..243	CDD:275380
		leucine-rich repeat	244..267	CDD:275380
		LRR_8	271..330	CDD:290566	14/62 (23%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	6/27 (22%)
		LRR_8	319..380	CDD:290566	15/61 (25%)
		leucine-rich repeat	320..343	CDD:275380	7/23 (30%)
		leucine-rich repeat	344..369	CDD:275380	3/24 (13%)
		LRR_8	368..428	CDD:290566	17/72 (24%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	4/22 (18%)
		leucine-rich repeat	418..441	CDD:275380	6/35 (17%)
farsb	NP_001007769.1	PLN02265	1..590	CDD:215149	60/269 (22%)
		B3_4	120..281	CDD:214876	43/199 (22%)
		B5	314..376	CDD:281482
		PheRS_beta_core	396..589	CDD:238392
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910