DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and scrib

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster

Alignment Length:	418	Identity:	111/418 - (26%)
Similarity:	166/418 - (39%)	Gaps:	139/418 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 HNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELIL 201
            :.|:|.:|:                   :.|.||.:|   ...|.::|          .|:||.|
  Fly    12 NRQVEFVDK-------------------RHCSLPQVP---EEILRYSR----------TLEELFL 44

  Fly   202 NDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQ 266
            :.|.:..|..|.|| ||                        :||||.||.|.:..|.|:    :|
  Fly    45 DANHIRDLPKNFFR-LH------------------------RLRKLGLSDNEIGRLPPD----IQ 80

  Fly   267 NFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAIL 331
            ||. :|.:||:|.|.|..:.|: .:.|..||:.|.|.|.|..| |:.|..|.:|..|.|. :..|
  Fly    81 NFE-NLVELDVSRNDIPDIPDD-IKHLQSLQVADFSSNPIPKL-PSGFSQLKNLTVLGLN-DMSL 141

  Fly   332 EIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEY 396
            ...||.|.:|..|::|:|..|.|:.|.|.|   :.|.:::||:|..|.::.|.|. ...||.|..
  Fly   142 TTLPADFGSLTQLESLELRENLLKHLPETI---SQLTKLKRLDLGDNEIEDLPPY-LGYLPGLHE 202

  Fly   397 LKLGHNELKSLDVRM---------------------------------------------FAPMR 416
            |.|.||:|:.|...:                                             .|.:.
  Fly   203 LWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLS 267

  Fly   417 RLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFP--------NLKRVAIEGN 473
            ||..|.|..|.|:.:| |.|.:..::||:::..|   ||:::..|..        |:.|.|:|..
  Fly   268 RLTILKLDQNRLQRLN-DTLGNCENMQELILTEN---FLSELPASIGQMTKLNNLNVDRNALEYL 328

  Fly   474 P---WQCPCFVKLQHWLATRDVVYLRDN 498
            |   .||          |...|:.||||
  Fly   329 PLEIGQC----------ANLGVLSLRDN 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	27/118 (23%)
		LRR_8	104..164	CDD:290566	3/26 (12%)
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380	3/15 (20%)
		leucine-rich repeat	154..195	CDD:275380	6/40 (15%)
		LRR_RI	194..455	CDD:238064	86/305 (28%)
		LRR_8	194..254	CDD:290566	18/59 (31%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	0/22 (0%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	21/58 (36%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR_8	319..380	CDD:290566	21/60 (35%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	21/104 (20%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	8/67 (12%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	89/338 (26%)
		leucine-rich repeat	18..38	CDD:275380	7/51 (14%)
		LRR_8	37..95	CDD:290566	29/97 (30%)
		leucine-rich repeat	39..61	CDD:275380	11/46 (24%)
		leucine-rich repeat	62..84	CDD:275380	12/26 (46%)
		LRR_8	84..138	CDD:290566	21/56 (38%)
		leucine-rich repeat	85..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..130	CDD:275380	10/22 (45%)
		LRR_8	129..187	CDD:290566	21/61 (34%)
		leucine-rich repeat	131..153	CDD:275380	8/22 (36%)
		leucine-rich repeat	154..176	CDD:275380	9/24 (38%)
		leucine-rich repeat	177..199	CDD:275380	7/22 (32%)
		LRR_8	198..256	CDD:290566	8/57 (14%)
		leucine-rich repeat	200..222	CDD:275380	7/21 (33%)
		leucine-rich repeat	223..245	CDD:275380	0/21 (0%)
		LRR_8	267..325	CDD:290566	17/61 (28%)
		leucine-rich repeat	269..289	CDD:275380	8/20 (40%)
		leucine-rich repeat	292..314	CDD:275380	6/24 (25%)
		leucine-rich repeat	315..337	CDD:275380	7/31 (23%)
		LRR_4	337..375	CDD:289563	5/10 (50%)
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910