DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and LRRC24

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_001019849.2 Gene:LRRC24 / 441381 HGNCID:28947 Length:513 Species:Homo sapiens


Alignment Length:310 Identity:78/310 - (25%)
Similarity:102/310 - (32%) Gaps:128/310 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   178 LELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLA 242
            :|.|..||.....|:.|..|.|.|.||.:.:|:..|                        ..|||
Human    34 VECGALRLRVVPLGIPPGTQTLFLQDNNIARLEPGA------------------------LAPLA 74

  Fly   243 QLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIA 307
            .||:|.|..|:|.||....|.|..    .|.:|.|:.||:|                        
Human    75 ALRRLYLHNNSLRALEAGAFRAQP----RLLELALTSNRLR------------------------ 111

  Fly   308 SLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRR 372
            .|....||||..||.|||..|.:..:...||..|..|..|.|..|::|.||:|...|        
Human   112 GLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAG-------- 168

  Fly   373 LNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLE 437
                           .|||..|:                           |..|.|..|:.:.|:
Human   169 ---------------LSSLALLD---------------------------LSRNQLGTISREALQ 191

  Fly   438 SLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWL 487
            .|:|:|.:     |||                  .|||:|.|.:   |||
Human   192 PLASLQVL-----RLT------------------ENPWRCDCAL---HWL 215

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 22/77 (29%)
LRR_8 104..164 CDD:290566
leucine-rich repeat 106..129 CDD:275380
leucine-rich repeat 130..153 CDD:275380
leucine-rich repeat 154..195 CDD:275380 5/16 (31%)
LRR_RI 194..455 CDD:238064 65/260 (25%)
LRR_8 194..254 CDD:290566 16/59 (27%)
leucine-rich repeat 196..219 CDD:275380 7/22 (32%)
leucine-rich repeat 220..243 CDD:275380 2/22 (9%)
leucine-rich repeat 244..267 CDD:275380 10/22 (45%)
LRR_8 271..330 CDD:290566 17/58 (29%)
leucine-rich repeat 272..295 CDD:275380 6/22 (27%)
leucine-rich repeat 296..319 CDD:275380 5/22 (23%)
LRR_8 319..380 CDD:290566 18/60 (30%)
leucine-rich repeat 320..343 CDD:275380 9/22 (41%)
leucine-rich repeat 344..369 CDD:275380 9/24 (38%)
LRR_8 368..428 CDD:290566 6/59 (10%)
leucine-rich repeat 370..393 CDD:275380 3/22 (14%)
leucine-rich repeat 394..417 CDD:275380 1/22 (5%)
leucine-rich repeat 418..441 CDD:275380 6/22 (27%)
LRRC24NP_001019849.2 LRR_RI 49..>158 CDD:238064 45/160 (28%)
LRR_8 <50..86 CDD:290566 16/59 (27%)
LRR 1 51..72 7/44 (16%)
leucine-rich repeat 53..75 CDD:275380 9/45 (20%)
LRR 2 75..96 9/20 (45%)
LRR_8 76..134 CDD:290566 27/85 (32%)
leucine-rich repeat 76..99 CDD:275380 10/26 (38%)
LRR 3 99..120 8/44 (18%)
leucine-rich repeat 100..123 CDD:275380 11/46 (24%)
LRR_8 123..205 CDD:290566 33/154 (21%)
LRR 4 123..144 8/20 (40%)
leucine-rich repeat 124..147 CDD:275380 9/22 (41%)
LRR 5 147..168 8/20 (40%)
leucine-rich repeat 148..171 CDD:275380 9/45 (20%)
LRR 6 171..192 8/47 (17%)
leucine-rich repeat 172..195 CDD:275380 8/49 (16%)
LRRCT 204..257 CDD:214507 8/15 (53%)
Ig 259..364 CDD:299845
IG_like 266..362 CDD:214653
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 365..391
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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