DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and sds22

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_650619.1	Gene:	sds22 / 42091	FlyBaseID:	FBgn0028992	Length:	326	Species:	Drosophila melanogaster

Alignment Length:	292	Identity:	79/292 - (27%)
Similarity:	133/292 - (45%)	Gaps:	38/292 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 LELGHNRLVN-ATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPL 241
            |:|.|.|:.. ..|....:::.|.|..|.:.:::  ....|..|:||:|..|:::.|  |....|
  Fly    44 LDLNHRRIEKLENFEPLTRIERLFLRWNLIKKIE--NLSSLKTLIELELYDNQITKI--ENLDDL 104

  Fly   242 AQLRKLNLSQNALDALR--------PNVFGAVQNFVLHLQQLDLSGNRIRL-LFDNQFR------ 291
            ..|..|::|.|.|..:.        ..|: .|.|.:..::.||:..|...| |.||:.:
  Fly   105 PHLEVLDISFNRLTKIENLDKLVKLEKVY-FVSNRITQIENLDMLTNLTMLELGDNKLKKIENIE 168

  Fly   292 VLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEF 356
            :|..|:.|.:.:|.||.:.  :...|.:|..|.||.|.|::|:  ....|.||..|.:|.|.:|.
  Fly   169 MLVNLRQLFLGKNKIAKIE--NLDTLVNLEILSLQANRIVKIE--NLEKLANLRELYVSENGVET 229

  Fly   357 LEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKS-LDVRMFAPMRRLQK 420
            :|.  ...||  ::..|:|..||:|.:..|  ..|..||.|.|.||.:.. .|:.:....:.||.
  Fly   230 IEN--LSENT--KLETLDLAKNRLKGIANL--EKLELLEELWLNHNGVDDWKDIELLKVNKALQT 288

  Fly   421 LHLGHN-LLEEINL-----DVLESLSSVQEIL 446
            ::|.:| |.:::..     |:|..|..:...|
  Fly   289 IYLEYNPLAKDVRYRSKLRDILPQLQKIDATL 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	22/78 (28%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	5/17 (29%)
		LRR_RI	194..455	CDD:238064	74/275 (27%)
		LRR_8	194..254	CDD:290566	16/59 (27%)
		leucine-rich repeat	196..219	CDD:275380	4/22 (18%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	7/30 (23%)
		LRR_8	271..330	CDD:290566	19/65 (29%)
		leucine-rich repeat	272..295	CDD:275380	8/29 (28%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	20/60 (33%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	18/61 (30%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	7/23 (30%)
		leucine-rich repeat	418..441	CDD:275380	8/28 (29%)
sds22	NP_650619.1	leucine-rich repeat	43..62	CDD:275380	5/17 (29%)
		LRR_8	61..117	CDD:290566	16/59 (27%)
		leucine-rich repeat	63..84	CDD:275380	4/22 (18%)
		LRR_4	83..125	CDD:289563	13/43 (30%)
		leucine-rich repeat	85..106	CDD:275380	8/22 (36%)
		LRR_8	105..183	CDD:290566	19/78 (24%)
		leucine-rich repeat	107..128	CDD:275380	5/20 (25%)
		LRR_4	128..168	CDD:289563	10/40 (25%)
		leucine-rich repeat	129..150	CDD:275380	5/21 (24%)
		LRR_4	149..189	CDD:289563	11/41 (27%)
		leucine-rich repeat	151..172	CDD:275380	5/20 (25%)
		leucine-rich repeat	173..194	CDD:275380	6/22 (27%)
		LRR_8	194..249	CDD:290566	20/60 (33%)
		LRR_4	194..235	CDD:289563	15/44 (34%)
		leucine-rich repeat	195..216	CDD:275380	8/22 (36%)
		leucine-rich repeat	217..238	CDD:275380	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910