DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and f-cup

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001262544.1	Gene:	f-cup / 41677	FlyBaseID:	FBgn0028487	Length:	802	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	97/374 - (25%)
Similarity:	155/374 - (41%)	Gaps:	79/374 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 SHNQMELLDRDFFGNLRKLIYANFSHNAL-----------------KQCDLPHMPL--------- 174
            :|...::|.::.:...||....|.|:.||                 |..:|..:.:
  Fly    91 THEDDQVLTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQ 155

  Fly   175 --LNRLELGHNRLVNATFGVCPQLQE------LILNDNQLIQLDVNAFRGLHGLLELQLSGNRLS 231
              ||.|:|..|.|.:    :.|:::.      |.|:||.|::|.....: |..|:.|.:|.|:||
  Fly   156 VPLNNLDLSSNTLTH----ISPKIENLQSLTVLTLHDNALVELPPEIGK-LEKLVRLNVSHNKLS 215

  Fly   232 SIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLH-LQQLDLSGNRIRLLFDNQFRVLAR 295
            .:....:. |.:||.||:|.|....|.|::..      || |:.||...|.|:.| ......|.|
  Fly   216 QLPRAMYS-LPELRHLNISYNEFVELNPDISD------LHMLEFLDGGHNNIQSL-PGGIGFLVR 272

  Fly   296 LQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQ 360
            |..|.:..|.|..| |...|.:.||:|:.|.:|.:..: |.....|..||.|.|.:|::  ||..
  Fly   273 LTALLLPYNHIKEL-PPDLVNMRSLQKIDLMHNDLTSL-PEDMGLLRKLDCLYLQHNDI--LELP 333

  Fly   361 IFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGH 425
            .|.||  ..:..|:.:.|.:|.:.....|:||.|:.|.|..|::..|.
  Fly   334 EFEGN--EALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELP----------------- 379

  Fly   426 NLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNP 474
                    |.|..|.::..:.|.||.::.|.....|..:|..:.:||||
  Fly   380 --------DELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNP 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	37/153 (24%)
		LRR_8	104..164	CDD:290566	6/27 (22%)
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380	2/16 (13%)
		leucine-rich repeat	154..195	CDD:275380	12/68 (18%)
		LRR_RI	194..455	CDD:238064	74/267 (28%)
		LRR_8	194..254	CDD:290566	21/65 (32%)
		leucine-rich repeat	196..219	CDD:275380	7/28 (25%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	21/59 (36%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	19/60 (32%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	11/59 (19%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	3/22 (14%)
f-cup	NP_001262544.1	leucine-rich repeat	111..140	CDD:275380	5/28 (18%)
		LRR_RI	155..>377	CDD:238064	73/240 (30%)
		leucine-rich repeat	158..180	CDD:275380	7/25 (28%)
		LRR_8	180..235	CDD:290566	19/56 (34%)
		leucine-rich repeat	181..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..226	CDD:275380	7/22 (32%)
		LRR_8	225..283	CDD:290566	21/64 (33%)
		leucine-rich repeat	227..249	CDD:275380	9/27 (33%)
		leucine-rich repeat	250..272	CDD:275380	7/22 (32%)
		LRR_8	272..329	CDD:290566	20/58 (34%)
		leucine-rich repeat	273..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..318	CDD:275380	6/22 (27%)
		LRR_8	317..375	CDD:290566	20/61 (33%)
		leucine-rich repeat	319..340	CDD:275380	10/24 (42%)
		leucine-rich repeat	341..364	CDD:275380	5/22 (23%)
		leucine-rich repeat	389..410	CDD:275380	5/20 (25%)
		leucine-rich repeat	411..430	CDD:275380	5/10 (50%)
		leucine-rich repeat	627..650	CDD:275380
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		LRR_8	719..777	CDD:290566
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910