DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and CG7800

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	121/449 - (26%)
Similarity:	180/449 - (40%)	Gaps:	96/449 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PNLRQ-LNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQC 167
            |:|.. .|.|.|.|:. |...|:.:.|.:..:|..:..|........|||.|...|.........
  Fly    18 PDLEDYCNDSYCHLLG-RSRTFSDKKATKLTEFHMDSCEKKVLKLMPNLRTLELENCDSPDFTMN 81

  Fly   168 DLPHMPLLNRLELGHNRLV---NATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNR 229
            ||..:|.|..|:|....|:   :..|...|.::.|:|..|.:.:|....|:||..|..|.|.||.
  Fly    82 DLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNG 146

  Fly   230 LSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLA 294
            :..:..:.||.|.:|..|:||.|.::.|..|:|..|..    |:.|.|:||.:..:.....:.|:
  Fly   147 IQGLPWDVFQNLPELLHLDLSGNRIETLHENIFTGVPK----LEMLLLNGNPLTWIAPTSLKSLS 207

  Fly   295 RLQMLDVSRNS---IASLSPAHFV-----G------LGSLRKLYLQYNAILEIK----------- 334
            .|::||:|...   ..||..||.:     |      |||:.||..:.|.|.|||
  Fly   208 NLRLLDMSNCGPLPDLSLPGAHTLILDNSGVQRLDILGSVHKLQARKNHITEIKLPDKSSVIELD 272

  Fly   335 -----------PATFAALLNLDTLDLSYNNLEFLEEQIFG-------GNT-----LPRMRRLNLN 376
                       |.....:..|..||||        |.|.|       .||     ||.:..:||:
  Fly   273 LHSNLLTATDIPKLLTGMWRLQRLDLS--------ENIIGIYAAAGSDNTSELFILPNLMYMNLS 329

  Fly   377 GNRMKHLHPLAFSS-LPF--LEYLKLGHNELKSLDVRMFAPMR-------RLQKLHLGHNLLEEI 431
            .||:..||   |.| :|:  |.:|...:|       |::||.:       .||.|||..|.:...
  Fly   330 ANRLTRLH---FDSPIPWERLTHLDASYN-------RIYAPAKVGIDEAFNLQSLHLEGNYINNF 384

  Fly   432 NLDVLESLSSVQEI-LVDN--------NRLTFLAKVNVSFPNLKRVAIEGN--PWQCPC 479
            .|...:...|::|: |.||        |...|..::.|:.....:.:...|  |...||
  Fly   385 ELTPWKPHPSLKEVALYDNKFQPKGYKNITKFFNEIGVNVLEKTQYSQSNNTTPTCKPC 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	45/155 (29%)
		LRR_8	104..164	CDD:290566	16/60 (27%)
		leucine-rich repeat	106..129	CDD:275380	7/23 (30%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	10/43 (23%)
		LRR_RI	194..455	CDD:238064	91/327 (28%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	9/22 (41%)
		LRR_8	271..330	CDD:290566	21/72 (29%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	10/36 (28%)
		LRR_8	319..380	CDD:290566	24/94 (26%)
		leucine-rich repeat	320..343	CDD:275380	8/44 (18%)
		leucine-rich repeat	344..369	CDD:275380	11/36 (31%)
		LRR_8	368..428	CDD:290566	22/69 (32%)
		leucine-rich repeat	370..393	CDD:275380	8/23 (35%)
		leucine-rich repeat	394..417	CDD:275380	6/29 (21%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	2/17 (12%)
		leucine-rich repeat	65..85	CDD:275380	6/19 (32%)
		LRR_8	87..147	CDD:290566	19/59 (32%)
		leucine-rich repeat	89..112	CDD:275380	5/22 (23%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	<131..334	CDD:238064	62/214 (29%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		LRR_8	140..195	CDD:290566	21/58 (36%)
		leucine-rich repeat	161..184	CDD:275380	9/22 (41%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..246	CDD:275380	10/36 (28%)
		leucine-rich repeat	247..267	CDD:275380	7/19 (37%)
		leucine-rich repeat	268..292	CDD:275380	1/23 (4%)
		leucine-rich repeat	293..322	CDD:275380	11/36 (31%)
		leucine-rich repeat	395..406	CDD:275378	4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453597
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940