DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and LUM

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_002336.1 Gene:LUM / 4060 HGNCID:6724 Length:338 Species:Homo sapiens


Alignment Length:348 Identity:86/348 - (24%)
Similarity:138/348 - (39%) Gaps:91/348 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 IYANFSHNALKQCDLPH----MPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFR 215
            ||...|.|...:|:.|.    ....:.|:|....:|.      |.::.|.|.:||:..:|..||.
Human    29 IYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVP------PGIKYLYLRNNQIDHIDEKAFE 87

  Fly   216 GLHGLLELQLSGNRL--SSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLS 278
            .:..|..|.|..|.|  |.|....|..|.||:||:::.|       |:..:|......|:.|.|:
Human    88 NVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHN-------NLTESVGPLPKSLEDLQLT 145

  Fly   279 GNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILE-IKPATFAALL 342
            .|:|..|                          ..|.||.:|..::||:|.:.| ...|.|..|.
Human   146 HNKITKL--------------------------GSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLK 184

  Fly   343 NLDTLDLSYNNLEFLEEQIFGGNTLP-RMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKS 406
            :|:.||||:|.:..|.      :.|| .:..|.|:.|::.::....|.....|:||:|.||||..
Human   185 SLEYLDLSFNQIARLP------SGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELAD 243

  Fly   407 LDVRMFAP-----MRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVN------- 459
            ..:    |     :..|.:|.|.:|.|:.|.             .|:.|...:..:||       
Human   244 SGI----PGNSFNVSSLVELDLSYNKLKNIP-------------TVNENLENYYLEVNQLEKFDI 291

  Fly   460 ---------VSFPNLKRVAIEGN 473
                     :|:..:|.:.::||
Human   292 KSFCKILGPLSYSKIKHLRLDGN 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 31/106 (29%)
LRR_8 104..164 CDD:290566 4/8 (50%)
leucine-rich repeat 106..129 CDD:275380
leucine-rich repeat 130..153 CDD:275380
leucine-rich repeat 154..195 CDD:275380 9/43 (21%)
LRR_RI 194..455 CDD:238064 71/269 (26%)
LRR_8 194..254 CDD:290566 22/61 (36%)
leucine-rich repeat 196..219 CDD:275380 7/22 (32%)
leucine-rich repeat 220..243 CDD:275380 9/24 (38%)
leucine-rich repeat 244..267 CDD:275380 6/22 (27%)
LRR_8 271..330 CDD:290566 13/58 (22%)
leucine-rich repeat 272..295 CDD:275380 6/22 (27%)
leucine-rich repeat 296..319 CDD:275380 3/22 (14%)
LRR_8 319..380 CDD:290566 20/62 (32%)
leucine-rich repeat 320..343 CDD:275380 8/23 (35%)
leucine-rich repeat 344..369 CDD:275380 9/25 (36%)
LRR_8 368..428 CDD:290566 18/65 (28%)
leucine-rich repeat 370..393 CDD:275380 4/22 (18%)
leucine-rich repeat 394..417 CDD:275380 9/27 (33%)
leucine-rich repeat 418..441 CDD:275380 6/22 (27%)
LUMNP_002336.1 LRRNT 37..71 CDD:214470 6/39 (15%)
LRR 1 67..88 7/20 (35%)
inl_like_NEAT_1 <68..>310 CDD:411101 74/297 (25%)
leucine-rich repeat 68..91 CDD:275380 7/22 (32%)
LRR 2 91..114 8/22 (36%)
leucine-rich repeat 92..117 CDD:275380 9/24 (38%)
LRR 3 117..137 7/26 (27%)
leucine-rich repeat 118..138 CDD:275380 6/26 (23%)
LRR 4 138..159 8/46 (17%)
leucine-rich repeat 139..160 CDD:275380 9/46 (20%)
LRR 5 160..181 6/20 (30%)
leucine-rich repeat 161..185 CDD:275380 8/23 (35%)
LRR 6 185..205 8/25 (32%)
leucine-rich repeat 186..206 CDD:275380 9/25 (36%)
LRR 7 206..227 4/20 (20%)
leucine-rich repeat 207..230 CDD:275380 4/22 (18%)
LRR 8 230..253 9/26 (35%)
leucine-rich repeat 231..255 CDD:275380 9/27 (33%)
LRR 9 255..276 7/33 (21%)
leucine-rich repeat 276..305 CDD:275380 3/28 (11%)
LRR 10 277..296 2/18 (11%)
LRR 11 305..326 3/10 (30%)
leucine-rich repeat 306..329 CDD:275380 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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