DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and tlr5b

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001124067.2	Gene:	tlr5b / 403139	ZFINID:	ZDB-GENE-040219-15	Length:	881	Species:	Danio rerio

Alignment Length:	634	Identity:	152/634 - (23%)
Similarity:	249/634 - (39%)	Gaps:	176/634 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLWLLCMGFPILHGADLCQPIGWRNFQC------------------------------SEVASL 45
            |:|:.||:...::.....|..||: |..|                              :..:.|
Zfish    13 LILFGLCLNTEVVKSTSECSVIGY-NAICINRGLHQVPELPAHVNYVDLSLNSIAELNETSFSRL 76

  Fly    46 QDLVDLGAENWHT-LAIRNVQTELEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQL 109
            |||..|..|.... |.|||          .....|::|:.|.|.....:.:.|..|:.|.||..|
Zfish    77 QDLQFLKVEQQTPGLVIRN----------NTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVL 131

  Fly   110 NLSGCGL--VDIRGNHFAPESALQRIDFSHNQMELLD-RDFFGNLRKLIYANFSHNALKQ-C--D 168
            .|:.|.|  ..:.||.|.|.::|:.:....|.::.:. ..||.|:|:....:.:.|.:|. |  |
Zfish   132 TLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEED 196

  Fly   169 L-----PHMPLL-----------------------------NRLELGHN--------RLVNATFG 191
            |     .|..||                             ..|:|..|        |..:|..|
Zfish   197 LLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAG 261

  Fly   192 VCPQLQELILNDN----------QLIQLDVNAFRGLH--GLLELQLSGNRLSSIGLETFQPLAQL 244
            .  ::|.|||:::          .....|...|:||.  |:....||.:::.::....|.....|
Zfish   262 T--KIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDL 324

  Fly   245 RKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASL 309
            .:|.|:||.::.:..|.|..    :.||.:|:||.|.:..:....|..|.:|::||:|.|.|.:|
Zfish   325 EQLTLAQNEINKIDDNAFWG----LTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRAL 385

  Fly   310 SPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLD-----------------------TLDLSY 351
            ....|:||.:||||.|..||:..:.  |||||.||:                       ||||.:
Zfish   386 GDQSFLGLPNLRKLNLTGNAVESVH--TFAALPNLNKLYLGKNRISSVSSLPNIAHNLSTLDLEF 448

  Fly   352 NNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSS------LPFLEYLKLGHNELKSLD-- 408
            |.|..|.:........|::..:.|.||        .|||      :...:.|:|.|..|.|:.
Zfish   449 NKLHALSDLYTILREFPQIENIFLQGN--------TFSSCYNQKQIVLSDKLQLLHLGLSSMQLI 505

  Fly   409 ------VRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAK---------V 458
                  :.:||.:.:||:|.|..|.|:.:..|:.:.|:|:..:.:..|.|.:|..         :
Zfish   506 WSEGKCLNVFADLHQLQQLSLTANGLQSLPKDIFKDLTSLFFLDLSFNSLKYLPTDVFPKSLQIL 570

  Fly   459 NVSF-------PN----LKRVAIEGNPWQCPCFVK-LQHWLATRDVVYL 495
            |:.:       ||    |..:::..|.::|.|.:| .|.||...:|.::
Zfish   571 NLDYNSIYSVDPNLFSTLSYLSLMNNDFRCDCDLKDFQTWLNQTNVTFV 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	48/212 (23%)
		LRR_8	104..164	CDD:290566	17/62 (27%)
		leucine-rich repeat	106..129	CDD:275380	9/24 (38%)
		leucine-rich repeat	130..153	CDD:275380	5/23 (22%)
		leucine-rich repeat	154..195	CDD:275380	14/85 (16%)
		LRR_RI	194..455	CDD:238064	83/309 (27%)
		LRR_8	194..254	CDD:290566	17/71 (24%)
		leucine-rich repeat	196..219	CDD:275380	8/34 (24%)
		leucine-rich repeat	220..243	CDD:275380	3/22 (14%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	24/58 (41%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	10/22 (45%)
		LRR_8	319..380	CDD:290566	25/83 (30%)
		leucine-rich repeat	320..343	CDD:275380	12/22 (55%)
		leucine-rich repeat	344..369	CDD:275380	8/47 (17%)
		LRR_8	368..428	CDD:290566	19/73 (26%)
		leucine-rich repeat	370..393	CDD:275380	6/28 (21%)
		leucine-rich repeat	394..417	CDD:275380	7/30 (23%)
		leucine-rich repeat	418..441	CDD:275380	8/22 (36%)
tlr5b	NP_001124067.2	leucine-rich repeat	55..78	CDD:275380	1/22 (5%)
		leucine-rich repeat	79..103	CDD:275380	8/33 (24%)
		LRR_8	102..164	CDD:290566	18/61 (30%)
		leucine-rich repeat	104..127	CDD:275380	6/22 (27%)
		leucine-rich repeat	128..153	CDD:275380	9/24 (38%)
		leucine-rich repeat	154..178	CDD:275380	5/23 (22%)
		leucine-rich repeat	179..236	CDD:275380	8/56 (14%)
		LRR_RI	<224..478	CDD:238064	68/269 (25%)
		LRR_8	298..356	CDD:290566	16/61 (26%)
		leucine-rich repeat	300..323	CDD:275380	3/22 (14%)
		leucine-rich repeat	324..347	CDD:275380	7/26 (27%)
		LRR_8	346..404	CDD:290566	23/57 (40%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		leucine-rich repeat	372..395	CDD:275380	10/22 (45%)
		LRR_8	394..451	CDD:290566	19/58 (33%)
		leucine-rich repeat	396..417	CDD:275380	12/22 (55%)
		leucine-rich repeat	441..482	CDD:275380	14/48 (29%)
		leucine-rich repeat	494..520	CDD:275380	6/25 (24%)
		LRR_8	520..577	CDD:290566	13/56 (23%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..563	CDD:275380	3/17 (18%)
		leucine-rich repeat	567..587	CDD:275380	3/19 (16%)
		LRRCT	596..645	CDD:214507	8/24 (33%)
		TIR	712..846	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910