DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and ltl

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	609	Identity:	135/609 - (22%)
Similarity:	227/609 - (37%)	Gaps:	155/609 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FPILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQTELEVGSGENA--DHLANL 82
            :.:.|.|.|         |||....:........:.|:     :|:...|.....||  |.|||.
  Fly     6 YTVFHLASL---------QCSVRPEISPCTCETGKAWN-----HVELSCEKLESFNAVVDSLANK 56

  Fly    83 LDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPES-ALQRIDFSHNQMELLDRD 146
            |:.|          ||        ..|.::...|.|:....|...: .|.::....|.::.|...
  Fly    57 LNAD----------TN--------IDLKITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLPEV 103

  Fly   147 FFGNLRKLIYANFSHNALKQCD---LPHMPLLNRLELGHNRL---VNATFGVCPQLQELILNDNQ 205
            .|..|..:.|.:...|.|.:..   |.|||.|..|::|..::   ....|....::..|||..|.
  Fly   104 PFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNI 168

  Fly   206 LIQLDVNAF---------------------RGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNL 249
            :.:||..:|                     ..||.|..|.::.|.::|:. :......|||.|..
  Fly   169 ITRLDRGSFPKSLLILHLGRNQLESLNGSLHDLHNLESLFINANNITSLD-DELPDGGQLRLLMA 232

  Fly   250 SQNALDALRPNVFG--AVQNFVLHLQQL-----------DLS-----GNRIRLLFDNQFRVLARL 296
            ..|.|:.|..|:.|  :::...:|..||           :||     .|.:..|..::|...:::
  Fly   233 HNNRLERLPANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADNNELEYLAQDEFASCSKV 297

  Fly   297 QMLDVSRNSIASL-----------------------SPAHFVGLGSLRKLYLQYNAILEIKP--- 335
            :.|.:..|.|.||                       |.|...||.||:.|.|..|.|..:.|
  Fly   298 ETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPR 362

  Fly   336 ---------------------ATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNR 379
                                 ...|.|.||..|:|:.|.||.|:...|.|  :.|:..|:|.||:
  Fly   363 GVQELMLVNLDLDNNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDFDG--MIRLDILDLTGNQ 425

  Fly   380 MKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQE 444
            :..|.||..:.||.|:.||:.:|.:..|: :.|..:..|.:.:|.:|           .:|::..
  Fly   426 LAELKPLEMTLLPSLKILKVAYNNITKLE-QDFKGLPVLCQANLTNN-----------QISTISS 478

  Fly   445 ILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFV-KLQHWLATRDVVYLRDNTGYYKGERPL 508
            .||.|.|..     |.:.|....:.::.||..|...: :|...:|.:: ..:|..:..::.::.:
  Fly   479 ELVTNTRCK-----NHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQE-ARIRGRSQCFENDQEV 537

  Fly   509 CIV------TNVDYCIQNLQAVRR 526
            |.|      .|:...:.||:...|
  Fly   538 CTVLPMLYNVNLPIMVTNLKLTGR 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	39/180 (22%)
		LRR_8	104..164	CDD:290566	11/60 (18%)
		leucine-rich repeat	106..129	CDD:275380	4/23 (17%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	11/46 (24%)
		LRR_RI	194..455	CDD:238064	82/346 (24%)
		LRR_8	194..254	CDD:290566	18/80 (23%)
		leucine-rich repeat	196..219	CDD:275380	8/43 (19%)
		leucine-rich repeat	220..243	CDD:275380	4/22 (18%)
		leucine-rich repeat	244..267	CDD:275380	8/24 (33%)
		LRR_8	271..330	CDD:290566	22/97 (23%)
		leucine-rich repeat	272..295	CDD:275380	7/38 (18%)
		leucine-rich repeat	296..319	CDD:275380	9/45 (20%)
		LRR_8	319..380	CDD:290566	24/84 (29%)
		leucine-rich repeat	320..343	CDD:275380	8/46 (17%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	19/59 (32%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..441	CDD:275380	3/22 (14%)
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	4/20 (20%)
		LRR_8	86..145	CDD:290566	15/58 (26%)
		leucine-rich repeat	87..110	CDD:275380	5/22 (23%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	4/22 (18%)
		LRR_8	158..214	CDD:290566	12/55 (22%)
		leucine-rich repeat	159..180	CDD:275380	7/20 (35%)
		leucine-rich repeat	181..203	CDD:275380	1/21 (5%)
		leucine-rich repeat	204..226	CDD:275380	4/22 (18%)
		LRR_RI	226..451	CDD:238064	59/226 (26%)
		leucine-rich repeat	227..249	CDD:275380	8/21 (38%)
		leucine-rich repeat	250..272	CDD:275380	3/21 (14%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..315	CDD:275380	5/17 (29%)
		LRR_8	319..402	CDD:290566	18/82 (22%)
		leucine-rich repeat	320..335	CDD:275378	0/14 (0%)
		leucine-rich repeat	344..366	CDD:275380	6/21 (29%)
		leucine-rich repeat	367..391	CDD:275380	2/23 (9%)
		LRR_8	369..426	CDD:290566	17/58 (29%)
		leucine-rich repeat	392..415	CDD:275380	9/24 (38%)
		leucine-rich repeat	416..439	CDD:275380	8/22 (36%)
		LRR_8	438..>479	CDD:290566	11/52 (21%)
		leucine-rich repeat	440..462	CDD:275380	6/22 (27%)
		leucine-rich repeat	463..483	CDD:275380	6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930