DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Gp150

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	151/582 - (25%)
Similarity:	235/582 - (40%)	Gaps:	152/582 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FPILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENWHTLAIRNVQTELEVGSGENADHLANLLD 84
            :|||.|.:..|.:|.:|....::|:. .|..|.||.:|               |.|..:..||.|
  Fly   302 YPILMGPNFFQNLGLKNVASIKIANC-TLEYLHAEAFH---------------GLNELYAVNLTD 350

  Fly    85 LDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHF-APESALQRIDFSHNQMELLDRDFF 148
            :   |.|.||..|  |.....||.|.:||..|..:...|: ...|:::.:|||.|.:..|:...|
  Fly   351 V---GLAIINPDT--FVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAF 410

  Fly   149 GNLRKLIYANFSHNALKQCDLPH-----MPLLNRLELGHNRLV-------NAT------------ 189
            .:|..::|.|.|.|:||:  ||.     :.||..|:|.:|.|.       |.|
  Fly   411 SHLSNVVYINLSQNSLKK--LPEKAFEKVTLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNTF 473

  Fly   190 -----FGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNL 249
                 ||. ..||:|.|:.|.::|:..:.|..:.||..|.|.||.:..|..::|..|..||.::|
  Fly   474 NGDLHFGT-KDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDL 537

  Fly   250 SQNALDALRPNVFGAVQNFVL---------HLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNS 305
            |.|.||.:...:|  .:|..|         .|.||...|   .|.:..:|.|    ..||:|..:
  Fly   538 SINDLDQISGMLF--FKNSELDVIRLNDNPRLSQLPTDG---FLSYSGEFTV----YYLDISNCA 593

  Fly   306 IASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRM 370
            |..|  .|                      ..|:.:.:|.||.|::||:..|..:||.|  |.::
  Fly   594 IGPL--GH----------------------KAFSTMPHLTTLKLAWNNINHLPREIFTG--LHKL 632

  Fly   371 RRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGH----NLLEEI 431
            ..|:|:.|.:..:..|.|.....|..|.|..|.:..|.||:|.|:.:|:.|.:..    .||.:.
  Fly   633 IDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDR 697

  Fly   432 NL----DVLESLSSVQEILVDNNRLTFLAKVNV-SFPNLKRVAIEGNPWQC-PCFVKLQHWLATR 490
            :|    .:.:||.|..   ...|.:..::..:| ||.||:.:.|..||.:| |.|.:.
  Fly   698 DLGAGYKIFDSLRSFN---ASGNLIKKISSEDVKSFKNLRSLDITNNPLKCTPDFQEF------- 752

  Fly   491 DVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQAV-RRLGILGDFQGEQVEADAFDDDASAAQ 551
                                   :.|....:|.. :||.:|.:          .:|||:..|
  Fly   753 -----------------------ISYVTLQMQMTPKRLPVLAN----------LEDDATIVQ 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	55/182 (30%)
		LRR_8	104..164	CDD:290566	19/60 (32%)
		leucine-rich repeat	106..129	CDD:275380	7/23 (30%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	18/69 (26%)
		LRR_RI	194..455	CDD:238064	74/277 (27%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	13/58 (22%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	15/60 (25%)
		leucine-rich repeat	320..343	CDD:275380	1/22 (5%)
		leucine-rich repeat	344..369	CDD:275380	11/24 (46%)
		LRR_8	368..428	CDD:290566	16/63 (25%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	7/30 (23%)
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	23/80 (29%)
		leucine-rich repeat	343..366	CDD:275380	9/27 (33%)
		leucine-rich repeat	367..391	CDD:275380	7/23 (30%)
		LRR_RI	<374..619	CDD:238064	75/280 (27%)
		LRR_8	390..450	CDD:290566	21/61 (34%)
		leucine-rich repeat	393..415	CDD:275380	7/21 (33%)
		leucine-rich repeat	416..439	CDD:275380	8/24 (33%)
		leucine-rich repeat	440..483	CDD:275380	9/43 (21%)
		leucine-rich repeat	463..481	CDD:275380	1/17 (6%)
		LRR_8	484..542	CDD:290566	21/57 (37%)
		leucine-rich repeat	484..507	CDD:275380	7/22 (32%)
		leucine-rich repeat	508..531	CDD:275380	8/22 (36%)
		leucine-rich repeat	532..569	CDD:275380	11/38 (29%)
		leucine-rich repeat	556..583	CDD:275380	6/29 (21%)
		leucine-rich repeat	570..607	CDD:275380	12/67 (18%)
		LRR_RI	<586..745	CDD:238064	49/187 (26%)
		LRR_8	606..666	CDD:290566	20/61 (33%)
		leucine-rich repeat	608..631	CDD:275380	11/24 (46%)
		leucine-rich repeat	632..655	CDD:275380	5/22 (23%)
		leucine-rich repeat	656..674	CDD:275380	7/17 (41%)
		leucine-rich repeat	733..745	CDD:275378	4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010