DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lbk

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	135/491 - (27%)
Similarity:	236/491 - (48%)	Gaps:	49/491 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PIGWRNFQCSEVASLQD--------LVDLGAENWH-------TLAIRNVQTELEVGSGENADHLA 80
            |.|.:....|...|:|.        :.|.|.:..|       ..|......:..:...::...|.
  Fly   209 PAGVQGSSSSSGISIQSGSLETNGFVADDGGQYEHAQKALEAAAAAAKASNKYNIDCPKDCKCLN 273

  Fly    81 NLLDLDLTGAAPINVHTNGFSILPN-LRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLD 144
            .|.|.|       .:|.....:||: ::.|:|:...|.|...........|.::....|.:|::.
  Fly   274 VLFDCD-------KLHLERVPVLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRNLLEVIP 331

  Fly   145 RDFFG--NLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVCPQ---LQELILNDN 204
            : |.|  .|:.|:.||....::....|..:|||..|:|..|:|........|:   |..|||:.|
  Fly   332 K-FIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLILSFN 395

  Fly   205 QLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFV 269
            ::..::.::|..|:.|.:|:||.||||::.:..|:.|.||:||.|:.|.|: :..:.|..:::
  Fly   396 EITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLE-INWSTFRGLES-- 457

  Fly   270 LHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIK 334
              ::.|.|..|:||.|.|..|.|:.:::.:|::.|.|:|||......|..||.|.|.:|||..|:
  Fly   458 --MKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIE 520

  Fly   335 PATFAALLNLDTLDLSYNNL-EFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLK 398
            ..|:....:|:.||||.|.: ||..:.:   :.|.|::.|||..||:::|....|..:..||.|.
  Fly   521 VDTWEFTQSLEVLDLSNNAINEFKPQHL---DCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELN 582

  Fly   399 LGHNELKSL--DVRMFAP---MRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKV 458
            |..|.|..:  |....||   :|:|::|.|..|.|::|:...:..|::::.:.:.:|.|..: :|
  Fly   583 LRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASI-QV 646

  Fly   459 NVSFPN---LKRVAIEGNPWQCPC-FVKLQHWLATR 490
            | :|.:   |.::..:...:.|.| .|..|.||..|
  Fly   647 N-AFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNR 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	48/158 (30%)
		LRR_8	104..164	CDD:290566	14/62 (23%)
		leucine-rich repeat	106..129	CDD:275380	4/22 (18%)
		leucine-rich repeat	130..153	CDD:275380	6/24 (25%)
		leucine-rich repeat	154..195	CDD:275380	11/40 (28%)
		LRR_RI	194..455	CDD:238064	87/269 (32%)
		LRR_8	194..254	CDD:290566	24/62 (39%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	21/58 (36%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	23/61 (38%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..369	CDD:275380	9/25 (36%)
		LRR_8	368..428	CDD:290566	22/64 (34%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	9/27 (33%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	51/178 (29%)
		leucine-rich repeat	293..316	CDD:275380	4/22 (18%)
		LRR_8	316..373	CDD:290566	16/57 (28%)
		leucine-rich repeat	317..338	CDD:275380	5/21 (24%)
		leucine-rich repeat	339..362	CDD:275380	5/22 (23%)
		leucine-rich repeat	363..386	CDD:275380	6/22 (27%)
		LRR_8	386..445	CDD:290566	23/58 (40%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	10/22 (45%)
		leucine-rich repeat	435..457	CDD:275380	7/22 (32%)
		LRR_8	457..516	CDD:290566	21/62 (34%)
		leucine-rich repeat	458..481	CDD:275380	9/22 (41%)
		leucine-rich repeat	482..505	CDD:275380	7/22 (32%)
		LRR_RI	<498..669	CDD:238064	51/175 (29%)
		LRR_8	504..564	CDD:290566	23/62 (37%)
		leucine-rich repeat	506..529	CDD:275380	9/22 (41%)
		leucine-rich repeat	530..553	CDD:275380	9/25 (36%)
		leucine-rich repeat	554..577	CDD:275380	7/22 (32%)
		LRR_8	576..641	CDD:290566	18/64 (28%)
		leucine-rich repeat	578..604	CDD:275380	9/25 (36%)
		leucine-rich repeat	607..630	CDD:275380	7/22 (32%)
		leucine-rich repeat	631..652	CDD:275380	5/22 (23%)
		LRRCT	665..712	CDD:214507	7/17 (41%)
		IG	734..823	CDD:214652
		Ig	735..823	CDD:143165
		I-set	834..924	CDD:254352
		Ig	851..924	CDD:299845
		IG	936..1027	CDD:214652
		Ig	961..1020	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910