DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and IGFALS

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001139478.1	Gene:	IGFALS / 3483	HGNCID:	5468	Length:	643	Species:	Homo sapiens

Alignment Length:	634	Identity:	178/634 - (28%)
Similarity:	250/634 - (39%)	Gaps:	168/634 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPLLLWLLCMGFPILHGADLCQPIGWRNFQCSE--VASLQDLVDLGAENWHTLAIRNVQTELEVG 71
            |.||.| :.:|...|.|||...|.......|..  |.|..|..|                ||.|.
Human    50 LLLLSW-VALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDAD----------------ELSVF 97

  Fly    72 SGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFA---PESALQRI 133
            .  ::.:|..|.|....|...:.:..|..|.:|.....|||..|.::::|....   |::.|...
Human    98 C--SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLE 160

  Fly   134 DFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGV---CPQ 195
            :..|..:|.      ..||.|....|:|.          |.|..|.|.:|||.....|:   ...
Human   161 NLCHLHLER------NQLRSLALGTFAHT----------PALASLGLSNNRLSRLEDGLFEGLGS 209

  Fly   196 LQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPN 260
            |.:|.|..|.|..|...|||||..|.||.|:||||:.:....|..||:||:|:||:|||.|::.|
Human   210 LWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 274

  Fly   261 VF---GAVQNFVLH-----------------LQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNS 305
            ||   ..:|...|.                 |:.||||.||:..|.::.|..|..|::|.:|.|:
Human   275 VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA 339

  Fly   306 IASLSP-----AHFV-------------------GLGSLRKLYLQYNAILEIKPATFAALLNLDT 346
            ||||.|     .||:                   |||.|..|.|.:|.:.|:|...|..|.|:..
Human   340 IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAV 404

  Fly   347 LDLSYNNLEFLEEQIF-----------GGNTLPRMR----------------------------- 371
            ::||.|.|..|.||:|           .|:.|.|:|
Human   405 MNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLW 469

  Fly   372 ------RLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEE 430
                  .|:|..|::.||....|..|..||||.|..|.|..|......|::|...|.:.||.||.
Human   470 GLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEA 534

  Fly   431 INLDVLESLSSVQEILVDNNRL-TFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVY 494
            :...:|..|..::.:.:.||.| ||..:.    |.|:|:.:|||||.|.|.:|.
Human   535 LPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKA----------- 584

  Fly   495 LRDNTGYYKGERPLCIVTNVDYCIQNLQAVRRLGILGDFQGEQVEADAF 543
            ||                  |:.:||..||.|. :....:|:..:..|:
Human   585 LR------------------DFALQNPSAVPRF-VQAICEGDDCQPPAY 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	53/158 (34%)
		LRR_8	104..164	CDD:290566	15/62 (24%)
		leucine-rich repeat	106..129	CDD:275380	6/25 (24%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	11/43 (26%)
		LRR_RI	194..455	CDD:238064	109/351 (31%)
		LRR_8	194..254	CDD:290566	28/59 (47%)
		leucine-rich repeat	196..219	CDD:275380	11/22 (50%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		leucine-rich repeat	244..267	CDD:275380	12/25 (48%)
		LRR_8	271..330	CDD:290566	28/99 (28%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	13/46 (28%)
		LRR_8	319..380	CDD:290566	24/106 (23%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	10/35 (29%)
		LRR_8	368..428	CDD:290566	22/94 (23%)
		leucine-rich repeat	370..393	CDD:275380	8/57 (14%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470	12/55 (22%)
		leucine-rich repeat	95..113	CDD:275380	4/19 (21%)
		leucine-rich repeat	114..137	CDD:275380	5/22 (23%)
		leucine-rich repeat	138..161	CDD:275380	4/22 (18%)
		LRR_8	141..196	CDD:290566	15/70 (21%)
		leucine-rich repeat	162..185	CDD:275380	7/38 (18%)
		LRR_8	184..244	CDD:290566	25/59 (42%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..233	CDD:275380	11/22 (50%)
		leucine-rich repeat	234..257	CDD:275380	10/22 (45%)
		LRR_8	257..316	CDD:290566	20/58 (34%)
		leucine-rich repeat	258..281	CDD:275380	12/22 (55%)
		leucine-rich repeat	282..305	CDD:275380	2/22 (9%)
		leucine-rich repeat	306..324	CDD:275380	8/17 (47%)
		LRR_8	336..388	CDD:290566	16/51 (31%)
		leucine-rich repeat	354..377	CDD:275380	2/22 (9%)
		LRR_8	377..433	CDD:290566	17/55 (31%)
		leucine-rich repeat	378..401	CDD:275380	8/22 (36%)
		leucine-rich repeat	402..423	CDD:275380	8/20 (40%)
		LRR_8	425..484	CDD:290566	7/58 (12%)
		leucine-rich repeat	426..447	CDD:275380	4/20 (20%)
		leucine-rich repeat	450..473	CDD:275380	0/22 (0%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		LRR_8	476..532	CDD:290566	20/55 (36%)
		leucine-rich repeat	498..519	CDD:275380	8/20 (40%)
		leucine-rich repeat	522..543	CDD:275380	6/20 (30%)
		LRR_8	524..575	CDD:290566	17/54 (31%)
		leucine-rich repeat	546..565	CDD:275380	5/22 (23%)
		TPKR_C2	574..618	CDD:301599	16/71 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	162	1.000	Inparanoid score	I4222
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299282at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.970