DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and LRRTM1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_849161.2	Gene:	LRRTM1 / 347730	HGNCID:	19408	Length:	522	Species:	Homo sapiens

Alignment Length:	341	Identity:	87/341 - (25%)
Similarity:	156/341 - (45%)	Gaps:	65/341 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 KLIYANFSHNALKQCDLPH-MPLLNRLELGHNRLVN---ATFGVCPQLQELILNDNQLIQLDVNA 213
            :|:|.    .||...:.|| :..|..|.|.:|.|..   ..|....||..|.|:.|.:..:..:|
Human    48 RLLYC----EALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDA 108

  Fly   214 FRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLS 278
            |:.|..:.||.||.|:::.:...||:|:..||.::||.|.|.||.|::|..::.    |..|.:.
Human   109 FQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRK----LTTLHMR 169

  Fly   279 GNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLN 343
            .|.|:.:....|:....|:.||:..|.:.||:...|.||..|.:|:|::|.::::..|.|..|::
Human   170 ANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLIS 234

  Fly   344 LDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLD 408
            |.:|.|..|.:..:...:   :.:..:.:::|:||.::::.|..|.::|.|:.|:|
Human   235 LHSLCLRRNKVAIVVSSL---DWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQL--------- 287

  Fly   409 VRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFL-AKVNVSFPNLKRVAIEG 472
                                                   |:||||:: .::..|:.:|..:.:.|
Human   288 ---------------------------------------DSNRLTYIEPRILNSWKSLTSITLAG 313

  Fly   473 NPWQCPCFV-KLQHWL 487
            |.|.|...| .|..||
Human   314 NLWDCGRNVCALASWL 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	34/106 (32%)
		LRR_8	104..164	CDD:290566	2/10 (20%)
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380	87/341 (26%)
		leucine-rich repeat	154..195	CDD:275380	12/44 (27%)
		LRR_RI	194..455	CDD:238064	65/260 (25%)
		LRR_8	194..254	CDD:290566	21/59 (36%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	10/22 (45%)
		LRR_8	271..330	CDD:290566	18/58 (31%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		LRR_8	319..380	CDD:290566	14/60 (23%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		leucine-rich repeat	344..369	CDD:275380	4/24 (17%)
		LRR_8	368..428	CDD:290566	9/59 (15%)
		leucine-rich repeat	370..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..417	CDD:275380	3/22 (14%)
		leucine-rich repeat	418..441	CDD:275380	0/22 (0%)
LRRTM1	NP_849161.2	LRR 1	64..87		6/22 (27%)
		LRR_8	73..125	CDD:290566	16/51 (31%)
		LRR_RI	<85..268	CDD:238064	55/189 (29%)
		LRR 2	89..111		7/21 (33%)
		leucine-rich repeat	91..114	CDD:275380	7/22 (32%)
		LRR 3	112..135		8/22 (36%)
		LRR_8	113..173	CDD:290566	21/63 (33%)
		leucine-rich repeat	115..138	CDD:275380	8/22 (36%)
		LRR 4	137..159		10/21 (48%)
		leucine-rich repeat	139..162	CDD:275380	10/22 (45%)
		LRR_8	161..221	CDD:290566	18/63 (29%)
		LRR 5	161..183		5/25 (20%)
		leucine-rich repeat	163..186	CDD:275380	5/22 (23%)
		LRR 6	184..207		7/22 (32%)
		leucine-rich repeat	187..210	CDD:275380	9/22 (41%)
		LRR 7	209..231		6/21 (29%)
		leucine-rich repeat	211..234	CDD:275380	7/22 (32%)
		LRR 8	233..255		4/24 (17%)
		leucine-rich repeat	235..257	CDD:275380	4/24 (17%)
		LRR 9	256..278		5/21 (24%)
		LRR_8	257..315	CDD:290566	17/105 (16%)
		LRR_4	257..297	CDD:289563	14/87 (16%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		LRR 10	279..302		9/70 (13%)
		leucine-rich repeat	282..300	CDD:275380	8/65 (12%)
		leucine-rich repeat	306..318	CDD:275378	4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910