DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and CG5096

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	337	Identity:	87/337 - (25%)
Similarity:	145/337 - (43%)	Gaps:	78/337 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 LELGHNRLVNATFGVCPQ--LQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSS-------- 232
            :.|.||.|.:..  :.|:  ::.|.|.:||:..:.|.||:.|..|:.|.||.|||:|
  Fly    87 INLEHNNLTSVP--ILPKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVF 149

  Fly   233 ---IGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRL---LFDNQFR 291
               ..::.|:.|..|:.|||..|.|.:|..::|    ..:.|:::|.|..|...:   |.:....
  Fly   150 KGPFTVQDFESLENLKTLNLGYNDLHSLDADLF----EHIPHIEELVLCSNSFHVIDQLSETAIS 210

  Fly   292 VLARLQMLDVSRNSIASLSPA--H-------FVGLGSLRKLYLQYNAILEIKPATFAALLNLDTL 347
            .|..|::||||...|..|...  |       |:..|:|      :|.:    |.......||.:|
  Fly   211 GLQSLKILDVSYMEIDDLPDTILHGPRDLEIFIAAGNL------FNQL----PKALKYATNLTSL 265

  Fly   348 DLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYL-KLGHNELKSLDVRM 411
            .|:.|.:    |.:.|.|..|.:.:|.       ||      |:.|:..| |:|..        .
  Fly   266 VLNENPI----ENLIGDNVFPPLTKLT-------HL------SMTFMSKLYKIGPG--------A 305

  Fly   412 FAPMRRLQKLHLGHN-LLEEINLDVLE---------SLSSVQEILVDNNRLTFLAK-VNVSFPNL 465
            |:.::.|.:|.|..| ||.||:.:.|.         ....::::.::|..::.|.| :.|.:..|
  Fly   306 FSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLVRWDKL 370

  Fly   466 KRVAIEGNPWQC 477
            |.:.:..|||.|
  Fly   371 KALDLRFNPWNC 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	29/90 (32%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	4/16 (25%)
		LRR_RI	194..455	CDD:238064	74/296 (25%)
		LRR_8	194..254	CDD:290566	24/72 (33%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	10/33 (30%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	18/70 (26%)
		leucine-rich repeat	272..295	CDD:275380	5/25 (20%)
		leucine-rich repeat	296..319	CDD:275380	9/31 (29%)
		LRR_8	319..380	CDD:290566	13/60 (22%)
		leucine-rich repeat	320..343	CDD:275380	3/22 (14%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	14/61 (23%)
		leucine-rich repeat	370..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..417	CDD:275380	4/23 (17%)
		leucine-rich repeat	418..441	CDD:275380	9/32 (28%)
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	83/331 (25%)
		leucine-rich repeat	85..104	CDD:275380	5/18 (28%)
		LRR_8	105..174	CDD:290566	23/68 (34%)
		leucine-rich repeat	105..128	CDD:275380	8/22 (36%)
		leucine-rich repeat	129..163	CDD:275380	10/33 (30%)
		LRR_8	163..222	CDD:290566	18/62 (29%)
		leucine-rich repeat	164..187	CDD:275380	8/26 (31%)
		leucine-rich repeat	188..214	CDD:275380	5/25 (20%)
		leucine-rich repeat	215..238	CDD:275380	8/22 (36%)
		leucine-rich repeat	239..261	CDD:275380	5/31 (16%)
		LRR_8	260..322	CDD:290566	22/86 (26%)
		leucine-rich repeat	262..286	CDD:275380	8/27 (30%)
		leucine-rich repeat	287..311	CDD:275380	9/44 (20%)
		leucine-rich repeat	346..369	CDD:275380	4/22 (18%)
		leucine-rich repeat	370..388	CDD:275380	6/13 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010