DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and Toll-4

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:645 Identity:136/645 - (21%)
Similarity:222/645 - (34%) Gaps:237/645 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 PILHGADLCQPIGWRNFQ-CSE---------VASLQDLVDL----GAENWHTLAIRNVQ------ 65
            |:.|        ||..|: |:|         |..::..||:    ..:....|.||.:.      
  Fly   134 PVFH--------GWNIFKICNETDYELVIISVLGIRSEVDMRISPAVQYLSLLGIREISGYDIYL 190

  Fly    66 -----TELEVGSGENADHLAN---------LLD---------------LDLTGAAPINVHT---- 97
                 ||::|       |.||         |.|               ::.|....|..|.    
  Fly   191 PSVLITEMDV-------HHANGPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEK 248

  Fly    98 ---------------------NGFSI-------LPNLRQLNLSGCGLVDIRGNHFAPESALQ--- 131
                                 ||..|       ..||..||......|.::...|...|.||   
  Fly   249 TTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSL 313

  Fly   132 -----RIDFSHNQMELLDRDFFGNLRKLI----YANFSHNALKQCDLPHMPLLNRLELGHNRLVN 187
                 ::|   |.::|...:.|.|| ::|    |..|.:.....|: |:.... :..||.|.:  
  Fly   314 TYCIMKVD---NMVDLKSFEKFTNL-EIIEVSQYKGFKNFTAFICE-PYKSHC-KFTLGINEV-- 370

  Fly   188 ATFGVCP------------QLQ----------------------ELILNDNQLIQLDVNAFRGLH 218
                .||            ||:                      .|:...|.|.:|..|:..|.|
  Fly   371 ----ACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYH 431

  Fly   219 GLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRP---------NVFGAVQN------F 268
            .|..|.:|.|:|:|:.:.  |....|..|::..|.:..|.|         |||....|      .
  Fly   432 NLKSLDVSYNQLTSLSVS--QLPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCD 494

  Fly   269 VLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEI 333
            ..|||:......::..:..::|:.:  ::.:::|  |..|.....||  .::.:|||:.|.. ||
  Fly   495 EYHLQEFFWYKAKLLRIKTSKFQTI--MEYIELS--SKGSFVENFFV--QNIDQLYLEANED-EI 552

  Fly   334 KPATFAALLNLDTLDLS--YNNLEFLE-------------EQIF-------------------GG 364
                      :|....|  |.||:.:|             ::|.                   .|
  Fly   553 ----------IDAFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTG 607

  Fly   365 NTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSL---DVRMFAPMRRLQKLHLGHN 426
            ..|...|.|:|:      ::|...:|:|:...|.|..||::.|   :..:.|....:.|||:..|
  Fly   608 EFLINCRNLSLD------IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQN 666

  Fly   427 LLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSF----PNLKRVAIEGNPWQCPCFVK 482
            ||.|:.|.:|.  .::..:.|.||.|.:|....::|    .|:.::.:.||||:|.|..|
  Fly   667 LLRELPLHLLP--ENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAK 724

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 44/198 (22%)
LRR_8 104..164 CDD:290566 18/71 (25%)
leucine-rich repeat 106..129 CDD:275380 5/22 (23%)
leucine-rich repeat 130..153 CDD:275380 8/30 (27%)
leucine-rich repeat 154..195 CDD:275380 10/56 (18%)
LRR_RI 194..455 CDD:238064 75/346 (22%)
LRR_8 194..254 CDD:290566 20/93 (22%)
leucine-rich repeat 196..219 CDD:275380 7/44 (16%)
leucine-rich repeat 220..243 CDD:275380 7/22 (32%)
leucine-rich repeat 244..267 CDD:275380 8/31 (26%)
LRR_8 271..330 CDD:290566 13/58 (22%)
leucine-rich repeat 272..295 CDD:275380 3/22 (14%)
leucine-rich repeat 296..319 CDD:275380 5/22 (23%)
LRR_8 319..380 CDD:290566 18/94 (19%)
leucine-rich repeat 320..343 CDD:275380 6/22 (27%)
leucine-rich repeat 344..369 CDD:275380 9/58 (16%)
LRR_8 368..428 CDD:290566 16/62 (26%)
leucine-rich repeat 370..393 CDD:275380 5/22 (23%)
leucine-rich repeat 394..417 CDD:275380 6/25 (24%)
leucine-rich repeat 418..441 CDD:275380 9/22 (41%)
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 5/22 (23%)
leucine-rich repeat 288..308 CDD:275380 4/19 (21%)
leucine-rich repeat 309..334 CDD:275380 6/27 (22%)
leucine-rich repeat 335..386 CDD:275380 11/59 (19%)
leucine-rich repeat 388..408 CDD:275380 0/19 (0%)
LRR_8 412..465 CDD:290566 17/54 (31%)
leucine-rich repeat 412..432 CDD:275378 6/19 (32%)
LRR_4 432..470 CDD:289563 11/39 (28%)
leucine-rich repeat 433..454 CDD:275378 7/22 (32%)
leucine-rich repeat 455..478 CDD:275378 5/22 (23%)
leucine-rich repeat 479..490 CDD:275378 4/10 (40%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 9/22 (41%)
leucine-rich repeat 680..706 CDD:275378 6/25 (24%)
leucine-rich repeat 707..719 CDD:275378 4/11 (36%)
leucine-rich repeat 771..791 CDD:275380
leucine-rich repeat 793..815 CDD:275378
leucine-rich repeat 816..835 CDD:275378
leucine-rich repeat 836..859 CDD:275378
TIR 974..1110 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453545
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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