DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and LRRC66

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001019782.1	Gene:	LRRC66 / 339977	HGNCID:	34299	Length:	880	Species:	Homo sapiens

Alignment Length:	222	Identity:	63/222 - (28%)
Similarity:	103/222 - (46%)	Gaps:	33/222 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 LVNATF-GVCPQLQELILNDNQ---LIQLDVNAFRGL---HGLLE------LQLSGNRLSSIGLE 236
            |.|.:| |.|    ::.::.:|   .:.:..|.||.|   |...|      |.||.|.:|.|.|.
Human    43 LTNCSFTGKC----DIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLS 103

  Fly   237 TFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDV 301
            .|..|..|..||||.||:.:|..::.....::|          .|.|..|.|:|.:   |::|.:
Human   104 PFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWV----------KRHRSSFRNRFPL---LKVLIL 155

  Fly   302 SRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNT 366
            .||.::. :|.....|.||:.|.|.:|.||:|..:.|...|.|:.|.|..|.:..:..|.|  ..
Human   156 QRNKLSD-TPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAF--KD 217

  Fly   367 LPRMRRLNLNGNRMKHLHPLAFSSLPF 393
            |.:::.::|:.|.:..:.|:...:|.|
Human   218 LKKLQVIDLSNNALITILPMMIIALEF 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	28/83 (34%)
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380	5/10 (50%)
		LRR_RI	194..455	CDD:238064	58/212 (27%)
		LRR_8	194..254	CDD:290566	22/71 (31%)
		leucine-rich repeat	196..219	CDD:275380	5/28 (18%)
		leucine-rich repeat	220..243	CDD:275380	10/28 (36%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR_8	271..330	CDD:290566	16/58 (28%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	19/60 (32%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	5/26 (19%)
		leucine-rich repeat	370..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..417	CDD:275380	63/222 (28%)
		leucine-rich repeat	418..441	CDD:275380
LRRC66	NP_001019782.1	LRR_RI	60..>255	CDD:238064	58/201 (29%)
		leucine-rich repeat	64..86	CDD:275380	6/21 (29%)
		LRR_8	86..160	CDD:290566	27/86 (31%)
		LRR 1	86..107		8/20 (40%)
		leucine-rich repeat	88..110	CDD:275380	9/21 (43%)
		LRR 2	110..130		8/19 (42%)
		leucine-rich repeat	111..149	CDD:275380	14/47 (30%)
		LRR 3	149..171		5/25 (20%)
		leucine-rich repeat	150..172	CDD:275380	6/22 (27%)
		LRR_8	171..231	CDD:290566	19/61 (31%)
		LRR 4	172..193		9/20 (45%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR 5	196..217		6/22 (27%)
		leucine-rich repeat	197..220	CDD:275380	7/24 (29%)
		LRR 6	220..241		3/20 (15%)
		leucine-rich repeat	221..242	CDD:275380	3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	679..746
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..816
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..880
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910