DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and lrrc40

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_956156.2	Gene:	lrrc40 / 334130	ZFINID:	ZDB-GENE-030131-6062	Length:	601	Species:	Danio rerio

Alignment Length:	469	Identity:	133/469 - (28%)
Similarity:	204/469 - (43%)	Gaps:	97/469 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 QLNLSGCGLVDI-----RGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQC 167
            ||||||.||.::     |.|...|:.|.|.:.|..........|    |.||:   .|.|.|:..
Zfish    38 QLNLSGRGLTEVPASVWRLNLDTPQEAKQNVSFGAEDRWWEQTD----LTKLL---LSSNKLQSI 95

  Fly   168 --DLPHMPLLNRLELGHNRLVNA--TFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGN 228
              |:..:|.|..|::..|:|.:.  :.|...|||:|||:.|:|.:|....:| |..|..|.|..|
Zfish    96 PDDVKLLPALVVLDIHDNQLSSLPDSIGDLEQLQKLILSHNKLTELPSGVWR-LTNLRCLHLQQN 159

  Fly   229 RLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVL 293
            .:..|..:..| |..|..|:||.|.|..: |.....:||.|    :||||.|:::.| ......:
Zfish   160 LIEQIPRDLGQ-LVNLDDLDLSNNHLIDI-PESLANLQNLV----KLDLSCNKLKSL-PPAISQM 217

  Fly   294 ARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAI---------------------LEIKPAT 337
            ..|:|||.|||.:.|:.|. ...:.||.:|||::|.:                     :|:..|.
Zfish   218 KNLRMLDCSRNQMESIPPV-LAQMESLEQLYLRHNKLRYLPELPCCKTLKELHCGNNQIEVLEAE 281

  Fly   338 FAALLN-LDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGH 401
            ....|| |..|:|..|.::.|.|:|   ..|..:.||:|..|.:..| |....:||.|:.|.|..
Zfish   282 HLKHLNALSLLELRDNKVKSLPEEI---TLLQGLERLDLTNNDISSL-PCGLGTLPKLKSLSLEG 342

  Fly   402 NELKSL--DV------RMFAPMR-RLQKLHLGHNLLEE------------INLDVLESLSSVQEI 445
            |.|:::  |:      .:...:| |:|:...| .|.||            ||:..:::|.:
Zfish   343 NPLRAIRRDLLTKGTGELLKYLRSRVQEPPNG-GLKEEPKTAMTFQSQAKINIHAIKTLKT---- 402

  Fly   446 LVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCPCFVKLQHWLATRDVVYLRD-----NTGYYKGE 505
                  |.:..|.:.|.|:....|::|||.....|.|.|.......:|.|:|     |.|:.|
Zfish   403 ------LDYSEKQDASIPDDVLDAVDGNPVANVNFSKNQLTAVPHRIVDLKDTLADINLGFNK-- 459

  Fly   506 RPLCIVTNV--DYC 517
                 :|.:  |:|
Zfish   460 -----LTTIPADFC 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	52/156 (33%)
		LRR_8	104..164	CDD:290566	20/60 (33%)
		leucine-rich repeat	106..129	CDD:275380	11/25 (44%)
		leucine-rich repeat	130..153	CDD:275380	4/22 (18%)
		leucine-rich repeat	154..195	CDD:275380	11/44 (25%)
		LRR_RI	194..455	CDD:238064	86/303 (28%)
		LRR_8	194..254	CDD:290566	23/59 (39%)
		leucine-rich repeat	196..219	CDD:275380	10/22 (45%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	21/58 (36%)
		leucine-rich repeat	272..295	CDD:275380	6/22 (27%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		LRR_8	319..380	CDD:290566	22/82 (27%)
		leucine-rich repeat	320..343	CDD:275380	7/43 (16%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	18/68 (26%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	7/31 (23%)
		leucine-rich repeat	418..441	CDD:275380	8/34 (24%)
lrrc40	NP_956156.2	LRR 1	33..56		8/17 (47%)
		LRR 2	79..101		8/28 (29%)
		LRR_8	82..138	CDD:290566	20/58 (34%)
		leucine-rich repeat	82..104	CDD:275380	7/24 (29%)
		LRR_RI	99..343	CDD:238064	78/256 (30%)
		LRR 3	102..124		5/21 (24%)
		leucine-rich repeat	105..127	CDD:275380	5/21 (24%)
		LRR 4	125..148		10/23 (43%)
		LRR_8	127..184	CDD:290566	23/58 (40%)
		leucine-rich repeat	128..150	CDD:275380	10/22 (45%)
		LRR 5	150..170		5/19 (26%)
		leucine-rich repeat	151..173	CDD:275380	7/22 (32%)
		LRR 6	171..193		8/22 (36%)
		leucine-rich repeat	174..196	CDD:275380	7/22 (32%)
		LRR 7	194..217		9/27 (33%)
		LRR_8	196..253	CDD:290566	23/62 (37%)
		leucine-rich repeat	197..219	CDD:275380	7/26 (27%)
		LRR 8	219..239		9/20 (45%)
		leucine-rich repeat	220..242	CDD:275380	9/22 (41%)
		LRR 9	240..264		6/23 (26%)
		leucine-rich repeat	243..288	CDD:275380	8/44 (18%)
		LRR_8	263..322	CDD:290566	16/61 (26%)
		LRR 10	266..285		2/18 (11%)
		LRR 11	286..308		9/24 (38%)
		leucine-rich repeat	289..311	CDD:275380	8/24 (33%)
		LRR 12	309..334		8/25 (32%)
		leucine-rich repeat	335..354	CDD:275380	6/18 (33%)
		LRR 13	336..355		5/18 (28%)
		LRR 14	397..420		5/32 (16%)
		leucine-rich repeat	400..449	CDD:275380	14/58 (24%)
		LRR 15	423..446		7/22 (32%)
		LRR 16	447..469		7/29 (24%)
		LRR_8	449..506	CDD:290566	6/27 (22%)
		leucine-rich repeat	450..472	CDD:275380	6/26 (23%)
		LRR 17	470..492
		leucine-rich repeat	473..495	CDD:275380
		LRR 18	493..516
		leucine-rich repeat	496..518	CDD:275380
		LRR_8	517..576	CDD:290566
		LRR 19	518..539
		leucine-rich repeat	519..542	CDD:275380
		LRR 20	540..563
		leucine-rich repeat	543..565	CDD:275380
		LRR 21	565..586
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910