DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6749 and kek5

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	189	Identity:	51/189 - (26%)
Similarity:	89/189 - (47%)	Gaps:	33/189 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LQMLDVSRNSIASLSPAHFV--GLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLE 358
            :|:||.:.|.|..|....|:  ||.::.|::|:...|.|:....|..|..|..||||
  Fly    75 MQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLS-------- 131

  Fly   359 EQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHL 423
                              |||::.|||..|:.|..|..:.:.:||::.|...:|..:..|.::..
  Fly   132 ------------------GNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEF 178

  Fly   424 GHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKR---VAIEGNPWQCPC 479
            .:|.|.::.|.|.....::..|.::.|||:.|.|  .:|.:|::   ::::||.|.|.|
  Fly   179 RNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHK--ETFKDLQKLMHLSLQGNAWNCSC 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064
		LRR_8	104..164	CDD:290566
		leucine-rich repeat	106..129	CDD:275380
		leucine-rich repeat	130..153	CDD:275380
		leucine-rich repeat	154..195	CDD:275380
		LRR_RI	194..455	CDD:238064	42/160 (26%)
		LRR_8	194..254	CDD:290566
		leucine-rich repeat	196..219	CDD:275380
		leucine-rich repeat	220..243	CDD:275380
		leucine-rich repeat	244..267	CDD:275380
		LRR_8	271..330	CDD:290566	11/35 (31%)
		leucine-rich repeat	272..295	CDD:275380
		leucine-rich repeat	296..319	CDD:275380	9/24 (38%)
		LRR_8	319..380	CDD:290566	13/60 (22%)
		leucine-rich repeat	320..343	CDD:275380	6/22 (27%)
		leucine-rich repeat	344..369	CDD:275380	5/24 (21%)
		LRR_8	368..428	CDD:290566	15/59 (25%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	5/22 (23%)
		leucine-rich repeat	418..441	CDD:275380	5/22 (23%)
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	31/109 (28%)
		leucine-rich repeat	76..100	CDD:275380	9/23 (39%)
		LRR_8	99..159	CDD:290566	21/85 (25%)
		leucine-rich repeat	101..124	CDD:275380	6/22 (27%)
		LRR	122..145	CDD:197688	13/48 (27%)
		leucine-rich repeat	125..148	CDD:275380	13/48 (27%)
		LRR_8	148..207	CDD:290566	12/58 (21%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	8/33 (24%)
		leucine-rich repeat	197..220	CDD:275380	8/24 (33%)
		LRRCT	229..277	CDD:214507	4/7 (57%)
		Ig	296..376	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840