DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Lgr6

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001028581.1	Gene:	Lgr6 / 329252	MGIID:	2441805	Length:	967	Species:	Mus musculus

Alignment Length:	509	Identity:	130/509 - (25%)
Similarity:	195/509 - (38%)	Gaps:	109/509 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLWL---LCM------------GFPILHGADLCQPIG-WRNFQCSEV------ASLQDL---VD 50
            |.|||   ||.            |.|.......||..| ..:..|||:      |.|..|   :|
Mouse     8 LALWLCAVLCASARAGSDPQPGPGRPACPAPCHCQEDGIMLSADCSELGLSVVPADLDPLTAYLD 72

  Fly    51 LGAENWHTLAIRNVQTELEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCG 115
            |...|         .|||:.|.   ..||..|.:|.|:|....::....||.|.:|:.|.|....
Mouse    73 LSMNN---------LTELQPGL---FHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQ 125

  Fly   116 LVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLEL 180
            |..|.........:||.:....|.:.|:....|..|..|.:.....|||  .::| :..||.|
Mouse   126 LRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL--TEIP-VRALNNL-- 185

  Fly   181 GHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLR 245
                         |.||.:.|..|.:..:...||:.|..|:.|.|..||:..:|..:|:.|..|.
Mouse   186 -------------PALQAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLE 237

  Fly   246 KLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLS 310
            .|:|:.|.|           |.|.|.:                  |.|.|||.|....|:|.::.
Mouse   238 TLDLNYNEL-----------QEFPLAI------------------RTLGRLQELGFHNNNIKAIP 273

  Fly   311 PAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLS-------------YNNLEFLEEQIF 362
            ...|:|...|:.::...|.|..:..:.|..|..|.||.|:             ..:||.|.....
Mouse   274 EKAFMGSPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILTLTRA 338

  Fly   363 G--------GNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQ 419
            |        ...|||:|.|.|:.|:::.|..|  .....||.:.|.||.:|.:....|:.:..||
Mouse   339 GIRLLPPGVCQQLPRLRILELSHNQIEELPSL--HRCQKLEEIGLRHNRIKEIGADTFSQLGSLQ 401

  Fly   420 KLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGN 473
            .|.|..|.:..|:.:...:|.|:.::.:.:|:||.|....:.  .|..:.::||
Mouse   402 ALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLG--GLMHLKLKGN 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	41/152 (27%)
		LRR_8	104..164	CDD:290566	13/59 (22%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	8/40 (20%)
		LRR_RI	194..455	CDD:238064	74/281 (26%)
		LRR_8	194..254	CDD:290566	20/59 (34%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	12/58 (21%)
		leucine-rich repeat	272..295	CDD:275380	2/22 (9%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		LRR_8	319..380	CDD:290566	20/81 (25%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..369	CDD:275380	9/45 (20%)
		LRR_8	368..428	CDD:290566	20/59 (34%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
Lgr6	NP_001028581.1	LRRNT	34..68	CDD:214470	8/33 (24%)
		LRR_4	70..107	CDD:289563	13/48 (27%)
		leucine-rich repeat	70..91	CDD:275380	9/32 (28%)
		LRR 1	91..112		5/20 (25%)
		LRR_8	92..150	CDD:290566	15/57 (26%)
		LRR_4	92..131	CDD:289563	12/38 (32%)
		leucine-rich repeat	92..115	CDD:275380	7/22 (32%)
		LRR 2	115..136		5/20 (25%)
		leucine-rich repeat	116..139	CDD:275380	5/22 (23%)
		LRR_8	138..198	CDD:290566	19/77 (25%)
		LRR 3	139..160		5/20 (25%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		LRR_RI	143..392	CDD:238064	74/297 (25%)
		LRR 4	163..186		8/40 (20%)
		leucine-rich repeat	164..187	CDD:275380	8/40 (20%)
		LRR_8	186..246	CDD:290566	20/59 (34%)
		LRR 5	187..208		6/20 (30%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		LRR 6	211..232		7/20 (35%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		LRR 7	235..256		9/49 (18%)
		leucine-rich repeat	236..258	CDD:275380	10/50 (20%)
		LRR_8	258..314	CDD:290566	17/55 (31%)
		LRR 8	258..279		7/20 (35%)
		leucine-rich repeat	259..282	CDD:275380	7/22 (32%)
		LRR 9	282..302		3/19 (16%)
		leucine-rich repeat	283..304	CDD:275380	4/20 (20%)
		LRR 10	303..325		5/21 (24%)
		LRR_8	305..364	CDD:290566	15/58 (26%)
		leucine-rich repeat	307..348	CDD:275380	8/40 (20%)
		LRR 11	329..350		4/20 (20%)
		LRR 12	353..374		7/22 (32%)
		leucine-rich repeat	354..375	CDD:275380	6/22 (27%)
		LRR_8	375..434	CDD:290566	16/58 (28%)
		LRR 13	375..396		7/20 (35%)
		leucine-rich repeat	376..399	CDD:275380	7/22 (32%)
		LRR 14	399..420		6/20 (30%)
		leucine-rich repeat	400..421	CDD:275380	6/20 (30%)
		LRR 15	423..443		5/19 (26%)
		leucine-rich repeat	424..444	CDD:275380	4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910