DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and AgaP_AGAP007442

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_564807.3	Gene:	AgaP_AGAP007442 / 3290369	VectorBaseID:	AGAP007442	Length:	453	Species:	Anopheles gambiae

Alignment Length:	530	Identity:	119/530 - (22%)
Similarity:	201/530 - (37%)	Gaps:	152/530 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSQTANWVLPLL-----LWLLCMGFPILHGADLCQPIGWRNFQCSEVASLQDLVDLGAENWHTLA 60
            |.....|.:.||     |||...|..|:..|.  ||.     |..|...:.|.::|.|:     .
Mosquito     1 MEVNREWTISLLLTLVNLWLWTNGPAIVQSAP--QPC-----QLQEAKCVYDKLNLSAD-----G 53

  Fly    61 IRNVQTELEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFA 125
            ::.::|     ||.:   |..:..:|:.           ..|.|                    .
Mosquito    54 LQRLRT-----SGRD---LPQVFQIDVK-----------LLITP--------------------Y 79

  Fly   126 PESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATF 190
            |:..|         ::|:. :|   :.:::|.|:....|:   :|  |:        :.|.:.|.
Mosquito    80 PDGVL---------LQLIS-EF---VVEVVYENYHERILR---IP--PI--------SALTDLTL 118

  Fly   191 GVCPQLQELIL--NDNQLIQLDV---------NAFRGLHGLLELQLSGNRLSSIGLETFQPLAQL 244
            ...|.||.:.:  ::|:|..|.:         :|...|..|..|.:....|.|:.||   |||..
Mosquito   119 RKAPPLQMIAVAASNNRLTTLSIKQSNIRSMPSALTNLRQLATLAIENGALESVSLE---PLANC 180

  Fly   245 RKLNL---SQNALDALRP----NVFGAVQNFVL-----------------HLQQLDLSGNRIRLL 285
            .||::   ..|.:..|.|    |:|..:.:..|                 .|..|||..|||:.:
Mosquito   181 LKLSILMCGNNKITQLIPSQNENLFVPLTDLTLASNLLETIDGAFFLPLRRLTYLDLGSNRIQRI 245

  Fly   286 FDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLS 350
             :.:...|.|:..:.:..|.:|.|....:: |.:..::|...|.:..| |.....|.||.||.:.
Mosquito   246 -EGRPLSLPRVMYIQLVSNQLAELDVTRWI-LPNAIEIYFDNNNLTRI-PIGIETLPNLTTLVVP 307

  Fly   351 YNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKH--LHPLAFSSLPFLEYLKLGHNELKSLDVRMFA 413
            .|.|..::.:...|.|  :::|:||.|||:..  :.....:|||.||.|.|.:|:|..|:...:
Mosquito   308 NNLLTVVDLRRLNGWT--KLQRINLAGNRLTKVIVTGQGRTSLPNLEQLDLSNNQLTHLEYARW- 369

  Fly   414 PMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQCP 478
               .|.||.:                     ::|..|:||.|..:...||.|:|.....||..|.
Mosquito   370 ---DLPKLSI---------------------LVVALNQLTRLPDLFKLFPKLRRAFAVQNPLHCN 410

  Fly   479 CFVKLQHWLA 488
            ...:.|.::|
Mosquito   411 TIRQWQQYIA 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	32/166 (19%)
		LRR_8	104..164	CDD:290566	7/59 (12%)
		leucine-rich repeat	106..129	CDD:275380	1/22 (5%)
		leucine-rich repeat	130..153	CDD:275380	3/22 (14%)
		leucine-rich repeat	154..195	CDD:275380	7/40 (18%)
		LRR_RI	194..455	CDD:238064	74/297 (25%)
		LRR_8	194..254	CDD:290566	20/73 (27%)
		leucine-rich repeat	196..219	CDD:275380	7/33 (21%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	7/29 (24%)
		LRR_8	271..330	CDD:290566	15/58 (26%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		LRR_8	319..380	CDD:290566	18/60 (30%)
		leucine-rich repeat	320..343	CDD:275380	5/22 (23%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	368..428	CDD:290566	19/61 (31%)
		leucine-rich repeat	370..393	CDD:275380	8/24 (33%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	3/22 (14%)
AgaP_AGAP007442	XP_564807.3	leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..182	CDD:275380	9/25 (36%)
		leucine-rich repeat	183..210	CDD:275380	6/26 (23%)
		LRR_8	208..265	CDD:290566	11/57 (19%)
		leucine-rich repeat	211..231	CDD:275380	1/19 (5%)
		leucine-rich repeat	232..277	CDD:275380	13/46 (28%)
		leucine-rich repeat	278..300	CDD:275380	5/22 (23%)
		LRR_RI	<299..>387	CDD:238064	31/114 (27%)
		LRR_8	299..361	CDD:290566	22/63 (35%)
		leucine-rich repeat	301..324	CDD:275380	7/24 (29%)
		LRR_4	323..365	CDD:289563	16/43 (37%)
		leucine-rich repeat	325..350	CDD:275380	8/24 (33%)
		LRR_8	349..407	CDD:290566	21/82 (26%)
		leucine-rich repeat	351..373	CDD:275380	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910