DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6749 and Lrrc8a

DIOPT Version :9

Sequence 1:NP_648354.1 Gene:CG6749 / 39144 FlyBaseID:FBgn0036040 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_001019953.1 Gene:Lrrc8a / 311846 RGDID:1311690 Length:810 Species:Rattus norvegicus


Alignment Length:505 Identity:137/505 - (27%)
Similarity:214/505 - (42%) Gaps:106/505 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ILHGADLCQPIGWRNFQ--CSEVASLQDLVDLGAENWHTL------AIRNVQTELEVG----SGE 74
            :||..|...|:..:.|.  .||| |...|..|...|..||      ..:|.|.:||:.    || 
  Rat   375 MLHLIDQYDPLYSKRFAVFLSEV-SENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSG- 437

  Fly    75 NADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQ 139
            ..|.:.:||:|::.....|    ...:|.|::.||.    ||.::...|.|.:.....:.|... 
  Rat   438 IPDTVFDLLELEVLKLELI----PDVTIPPSIAQLT----GLKELWLYHTAAKIEAPALAFLRE- 493

  Fly   140 MELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPL-------LNRLEL-GHNRLVNATFGVCPQL 196
                      |||.|      |  :|..|:..:||       |..|.| |:....|..:.|...|
  Rat   494 ----------NLRAL------H--IKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540

  Fly   197 QEL----IL----NDNQLIQL--DVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQ 251
            :||    :|    |.::|.|:  ||    |:| |.:|.::......|.|.:.:.:..|.:|.|.:
  Rat   541 RELKRLKVLRLKSNLSKLPQVVTDV----GVH-LQKLSINNEGTKLIVLNSLKKMVNLTELELIR 600

  Fly   252 NALDALRPNVFGAVQNFVLH-LQQLDLSGNRIRLLFD-NQFRVLARLQMLDVSRNSIASLSPAHF 314
            ..|:.:..::|.      || ||::||..|.::.:.: ..|:.|.||..|.:..|.||.: |...
  Rat   601 CDLERIPHSIFS------LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI-PIQI 658

  Fly   315 VGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNR 379
            ..|.:|.:|||..|.|.:| |........|..||||:|||..|...|   ..|..::.|.:..||
  Rat   659 GNLTNLERLYLNRNKIEKI-PTQLFYCRKLRYLDLSHNNLTLLPADI---GLLQNLQNLAVTANR 719

  Fly   380 MKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQE 444
            ::.|.|..|.                         .|:|:.||||:|:|:.:...|.| |:::.:
  Rat   720 IEALPPELFQ-------------------------CRKLRALHLGNNVLQSLPSRVGE-LTNLTQ 758

  Fly   445 ILVDNNRLTFLAKVNVSFPNLKR--VAIEGNPWQ-CPCFVKLQHWLATRD 491
            |.:..|||..|.......|.|||  :.:|.:.:. .|..||.:.|.|.::
  Rat   759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFSTLPPEVKERLWRADKE 808

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG6749NP_648354.1 LRR_RI 103..>256 CDD:238064 42/170 (25%)
LRR_8 104..164 CDD:290566 13/59 (22%)
leucine-rich repeat 106..129 CDD:275380 6/22 (27%)
leucine-rich repeat 130..153 CDD:275380 3/22 (14%)
leucine-rich repeat 154..195 CDD:275380 12/48 (25%)
LRR_RI 194..455 CDD:238064 77/272 (28%)
LRR_8 194..254 CDD:290566 18/69 (26%)
leucine-rich repeat 196..219 CDD:275380 10/32 (31%)
leucine-rich repeat 220..243 CDD:275380 4/22 (18%)
leucine-rich repeat 244..267 CDD:275380 5/22 (23%)
LRR_8 271..330 CDD:290566 21/60 (35%)
leucine-rich repeat 272..295 CDD:275380 7/23 (30%)
leucine-rich repeat 296..319 CDD:275380 7/22 (32%)
LRR_8 319..380 CDD:290566 21/60 (35%)
leucine-rich repeat 320..343 CDD:275380 8/22 (36%)
leucine-rich repeat 344..369 CDD:275380 11/24 (46%)
LRR_8 368..428 CDD:290566 13/59 (22%)
leucine-rich repeat 370..393 CDD:275380 6/22 (27%)
leucine-rich repeat 394..417 CDD:275380 0/22 (0%)
leucine-rich repeat 418..441 CDD:275380 10/22 (45%)
Lrrc8aNP_001019953.1 Pannexin_like 1..340 CDD:403656
LRR 1. /evidence=ECO:0000255 399..422 5/22 (23%)
LRR 2. /evidence=ECO:0000255 423..445 7/22 (32%)
LRR 3. /evidence=ECO:0000255 447..468 4/24 (17%)
LRR 4. /evidence=ECO:0000255 469..492 5/26 (19%)
leucine-rich repeat 471..494 CDD:275380 4/33 (12%)
LRR 5. /evidence=ECO:0000255 493..515 9/40 (23%)
leucine-rich repeat 495..517 CDD:275380 8/29 (28%)
LRR 510..>767 CDD:227223 83/298 (28%)
leucine-rich repeat 518..545 CDD:275380 9/26 (35%)
LRR 6. /evidence=ECO:0000255 518..542 7/23 (30%)
LRR 7. /evidence=ECO:0000255 543..565 5/21 (24%)
leucine-rich repeat 546..568 CDD:275380 7/25 (28%)
LRR 8. /evidence=ECO:0000255 567..589 5/22 (23%)
leucine-rich repeat 569..592 CDD:275380 4/22 (18%)
LRR 9. /evidence=ECO:0000255 590..613 5/28 (18%)
leucine-rich repeat 593..615 CDD:275380 6/27 (22%)
LRR 10. /evidence=ECO:0000255 614..637 7/22 (32%)
leucine-rich repeat 616..640 CDD:275380 7/23 (30%)
LRR 11. /evidence=ECO:0000255 639..661 7/22 (32%)
leucine-rich repeat 641..663 CDD:275380 7/22 (32%)
LRR 12. /evidence=ECO:0000255 662..684 8/22 (36%)
leucine-rich repeat 664..686 CDD:275380 8/22 (36%)
LRR 13. /evidence=ECO:0000255 686..707 10/23 (43%)
leucine-rich repeat 687..709 CDD:275380 11/24 (46%)