DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Lrrc8e

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001029311.1	Gene:	Lrrc8e / 304203	RGDID:	1311979	Length:	795	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	128/512 - (25%)
Similarity:	201/512 - (39%)	Gaps:	165/512 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AIRNVQTELEVGSGENAD---------HLANLLDLDLTGAAPINVHTNGFSIL------PNLRQL 109
            :.|:|:.  |.|..:..|         ||.:..|         ::::..|::.      ..|:||
  Rat   342 SFRSVRE--ETGMNDIPDVRNDFAFMLHLIDQYD---------SLYSKRFAVFLSEVSESRLKQL 395

  Fly   110 NLSGCGLVDIRGNH-FAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMP 173
            ||          || :.|:...|:          |.|:..|.|.           |..|.||.:|
  Rat   396 NL----------NHEWTPDKLRQK----------LQRNARGRLE-----------LSLCMLPGLP 429

  Fly   174 ----LLNRLEL-------------GHNRLVNATFGVCPQLQEL---------------ILND--- 203
                .|:.:|.             |.::|||        ||||               .|.|
  Rat   430 DTVFELSEVEALRLEAICDISFPPGLSQLVN--------LQELSLLHSPARLPFSSQIFLRDRLK 486

  Fly   204 ------NQLIQLDVNAFRGLHGLLELQLSG----NRLSSIGLETFQPLAQLRKLNLSQNALDALR 258
                  .:|.::.:..| ||.||.||.|.|    .......||:.:.|.||:.|:|..||
  Rat   487 VICVKFEELREVPLWVF-GLRGLEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNA----- 545

  Fly   259 PNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKL 323
            ..|..:|.:...|||:|.|..:..|||..|..:.||.|:.|::....:..:..|.| .||:|::|
  Rat   546 GKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLERIPHAIF-SLGALQEL 609

  Fly   324 YLQYNAILEIK------------------------PATFAALLNLDTLDLSYNNLEFLEEQI--- 361
            .|:.|.:..|:                        |.....|.:|:.|.||:|.||.|..|:
  Rat   610 DLKDNHLRSIEEILSFQHCRKLVILRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQC 674

  Fly   362 FGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQKLHLGHN 426
            ||      :|.|:::.|.::.|.| ....|..|::|.|.:|.|:||...:|. ..:|:.|.||:|
  Rat   675 FG------LRLLDVSHNGLRSLPP-ELGLLQSLQHLALSYNALESLPDELFF-CHKLRTLLLGYN 731

  Fly   427 LLEEINLDV--LESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAI-------EGNP 474
            .|.:.:..|  |::||.::   :..|||..|.:.......||:..:       ||.|
  Rat   732 HLTQFSPHVAALQALSRLE---LKGNRLEALPEELGDCKGLKKSGLLVEDTLYEGLP 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	49/204 (24%)
		LRR_8	104..164	CDD:290566	13/60 (22%)
		leucine-rich repeat	106..129	CDD:275380	8/23 (35%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..195	CDD:275380	11/57 (19%)
		LRR_RI	194..455	CDD:238064	89/317 (28%)
		LRR_8	194..254	CDD:290566	24/87 (28%)
		leucine-rich repeat	196..219	CDD:275380	10/46 (22%)
		leucine-rich repeat	220..243	CDD:275380	8/26 (31%)
		leucine-rich repeat	244..267	CDD:275380	7/22 (32%)
		LRR_8	271..330	CDD:290566	21/58 (36%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		LRR_8	319..380	CDD:290566	21/87 (24%)
		leucine-rich repeat	320..343	CDD:275380	7/46 (15%)
		leucine-rich repeat	344..369	CDD:275380	11/27 (41%)
		LRR_8	368..428	CDD:290566	19/59 (32%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	8/22 (36%)
		leucine-rich repeat	418..441	CDD:275380	9/24 (38%)
Lrrc8e	NP_001029311.1	Pannexin_like	1..330	CDD:289311
		leucine-rich repeat	508..532	CDD:275380	7/23 (30%)
		LRR_RI	526..790	CDD:238064	79/277 (29%)
		LRR 1	535..556		8/25 (32%)
		leucine-rich repeat	536..558	CDD:275380	7/26 (27%)
		LRR 2	558..578		9/19 (47%)
		leucine-rich repeat	559..582	CDD:275380	9/22 (41%)
		LRR 3	582..603		4/21 (19%)
		LRR_8	583..641	CDD:290566	11/58 (19%)
		leucine-rich repeat	583..605	CDD:275380	5/22 (23%)
		LRR 4	605..626		5/20 (25%)
		leucine-rich repeat	606..630	CDD:275380	5/23 (22%)
		LRR_8	629..687	CDD:290566	16/63 (25%)
		LRR 5	630..651		1/20 (5%)
		leucine-rich repeat	631..653	CDD:275380	2/21 (10%)
		LRR 6	653..674		9/20 (45%)
		leucine-rich repeat	654..676	CDD:275380	9/21 (43%)
		LRR_8	676..733	CDD:290566	20/64 (31%)
		LRR 7	676..697		6/27 (22%)
		leucine-rich repeat	677..699	CDD:275380	6/22 (27%)
		LRR 8	699..720		8/21 (38%)
		leucine-rich repeat	700..722	CDD:275380	8/22 (36%)
		LRR 9	722..743		7/20 (35%)
		leucine-rich repeat	723..745	CDD:275380	8/21 (38%)
		LRR 10	745..766		6/23 (26%)
		leucine-rich repeat	746..766	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910