DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6749 and Lrrd1

DIOPT Version :9

Sequence 1:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_216085.3	Gene:	Lrrd1 / 296836	RGDID:	1562785	Length:	855	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	129/598 - (21%)
Similarity:	201/598 - (33%)	Gaps:	235/598 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DLTGAAPINVHTNGFSILP-------NLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELL 143
            ||.|...:::..||.|.:|       ||:.||.|                   ..:.||...|||
  Rat   182 DLLGLETLSLQENGLSSIPQEIQLFHNLKVLNAS-------------------YNEISHIPKELL 227

  Fly   144 DRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNATFGVC--------------- 193
            .   .||:|:| :.|.:|.......|.::..|..|.||.|||.:....:|
  Rat   228 Q---LGNMRQL-FLNSNHIESLPSGLENLRYLETLSLGKNRLTHIPDSLCGLKNLKTLNLEYNQL 288

  Fly   194 ----------PQLQELILNDNQLIQL--DVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRK 246
                      |:|..|.|..|.:..|  :|...:.|..||   ::.|:|:.:.:|.|| |.::::
  Rat   289 TIFSKSLCFLPKLVSLNLTGNMIGSLPKEVRELKNLENLL---MNHNKLTFLAVEIFQ-LLKIKE 349

  Fly   247 LNLSQNALDALRPNVFGAVQNF----------------------VLHLQQLDLSGNRIRLLFDNQ 289
            |:|:.|.|:|:.|.    ::||                      .::|:.|.||.|.:..| ..:
  Rat   350 LHLADNKLEAISPK----IENFKELRLLNLDNNLLQSLPKKISHCVNLESLTLSDNNLEEL-PKK 409

  Fly   290 FRVLARLQMLDVSRN-------SIASLSPAHF--------------------------------- 314
            .|.|..|:.|..:||       .|:.||..|.
  Rat   410 IRKLKNLRQLHANRNKMIKMAEEISHLSKIHSLEFSGNQITHVPIEIKNCKEITRVELNYNNIMY 474

  Fly   315 --VGLGSLRKL-YLQYN------------------------------------------------ 328
              |||.:|:.| ||.:|
  Rat   475 FPVGLCALQSLDYLSFNGNYISEIPVDLSFSKQLLHLELNKNKITIFSEHLCSLTNLEYLDLAKN 539

  Fly   329 ----------AIL------------EIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMR 371
                      |:|            ||.|....:|.||..||:|.|.|..:..:|   :.|.:::
  Rat   540 QIRKIPHCISAMLSLHVLILSDNKFEIFPKELCSLKNLQLLDISENQLHKIPSEI---SKLKKIQ 601

  Fly   372 RLNLNGNRMKHLHPLAFSSLPFLEYLKLGH----------------NELKSLDV---------RM 411
            :|||:.|...|. |.....|..||.|.:..                .:||:|::         |.
  Rat   602 KLNLSNNNFTHF-PAELCQLQTLEDLNISQISGKKLTRLPEEVSRMTQLKALNISNNAIKEIPRN 665

  Fly   412 FAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVDNNRLTFLAKVNVSFPNLKRVAIEGNPWQ 476
            ...:|.|...|..:|.:..:....| ||:.:|.:.:..|.||.|........:||.:..:.||..
  Rat   666 IGELRNLITFHASNNQINSLPSSFL-SLNVLQSLDLGGNNLTDLPSAIYKLSSLKEINFDDNPLL 729

  Fly   477 CP----CFVKLQH 485
            .|    |..|..|
  Rat   730 RPPMEICKGKQMH 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	46/186 (25%)
		LRR_8	104..164	CDD:290566	17/66 (26%)
		leucine-rich repeat	106..129	CDD:275380	4/22 (18%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	12/65 (18%)
		LRR_RI	194..455	CDD:238064	88/422 (21%)
		LRR_8	194..254	CDD:290566	19/61 (31%)
		leucine-rich repeat	196..219	CDD:275380	7/24 (29%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	24/159 (15%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	11/64 (17%)
		LRR_8	319..380	CDD:290566	24/131 (18%)
		leucine-rich repeat	320..343	CDD:275380	11/93 (12%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	18/84 (21%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	7/47 (15%)
		leucine-rich repeat	418..441	CDD:275380	6/22 (27%)
Lrrd1	XP_216085.3	leucine-rich repeat	162..185	CDD:275380	2/2 (100%)
		LRR_8	185..242	CDD:290566	20/79 (25%)
		leucine-rich repeat	186..208	CDD:275380	4/21 (19%)
		leucine-rich repeat	209..231	CDD:275380	9/43 (21%)
		leucine-rich repeat	232..254	CDD:275380	5/22 (23%)
		LRR_RI	253..564	CDD:238064	58/319 (18%)
		LRR_8	253..311	CDD:290566	13/57 (23%)
		leucine-rich repeat	255..277	CDD:275380	8/21 (38%)
		leucine-rich repeat	278..300	CDD:275380	0/21 (0%)
		LRR_8	299..357	CDD:290566	19/61 (31%)
		leucine-rich repeat	301..323	CDD:275380	6/21 (29%)
		leucine-rich repeat	324..346	CDD:275380	9/25 (36%)
		leucine-rich repeat	347..392	CDD:275380	8/48 (17%)
		leucine-rich repeat	439..461	CDD:275380	1/21 (5%)
		leucine-rich repeat	463..484	CDD:275380	4/20 (20%)
		leucine-rich repeat	487..507	CDD:275380	3/19 (16%)
		leucine-rich repeat	508..530	CDD:275380	0/21 (0%)
		leucine-rich repeat	531..553	CDD:275380	1/21 (5%)
		LRR_RI	537..>728	CDD:238064	44/195 (23%)
		LRR_8	553..610	CDD:290566	17/59 (29%)
		leucine-rich repeat	554..576	CDD:275380	4/21 (19%)
		leucine-rich repeat	577..599	CDD:275380	8/24 (33%)
		leucine-rich repeat	600..648	CDD:275380	10/48 (21%)
		leucine-rich repeat	649..671	CDD:275380	4/21 (19%)
		LRR_8	670..728	CDD:290566	15/58 (26%)
		leucine-rich repeat	672..694	CDD:275380	6/22 (27%)
		leucine-rich repeat	695..717	CDD:275380	5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910